DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpB and capn12

DIOPT Version :10

Sequence 1:NP_524016.4 Gene:CalpB / 39165 FlyBaseID:FBgn0025866 Length:925 Species:Drosophila melanogaster
Sequence 2:XP_031746547.1 Gene:capn12 / 100486294 XenbaseID:XB-GENE-1008507 Length:674 Species:Xenopus tropicalis


Alignment Length:659 Identity:221/659 - (33%)
Similarity:341/659 - (51%) Gaps:50/659 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   283 EWLRPGDIADDPQFFVEGYSRFDVQQGELGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGI 347
            ||.||.:|...|:|.::|.:|.||.||:|.:||.|:|.|.|:....|..:|:.|.|||...|.|.
 Frog    50 EWRRPQEICAKPRFILDGATRMDVCQGKLSNCWFLSAVACLSLYPQLLEKVVLPGQDFVGAYDGK 114

  Fly   348 FHFKFWQYGKWVEVVIDDRLPT----------YNG---ELIYMHSTEKNEFWSALLEKAYAKLHG 399
            |.|:|||||:||.|.|||||||          :|.   ||::|||.:|:||||:|||||||||.|
 Frog   115 FRFQFWQYGQWVLVEIDDRLPTVRIQRNEEAAHNREEYELLFMHSWKKDEFWSSLLEKAYAKLKG 179

  Fly   400 SYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMK-AAERGSMMGC-SLEPDPHVLEAET 462
            .|.||:.|...||:.|.||||.:.. ....|.|:..:.:. ..::|::..| :.|.:   ||...
 Frog   180 GYSALQLGFAGEALVDMTGGVAQTC-YTNGPLNMLWVSLSHLLQQGALTCCGNTEGE---LEMAN 240

  Fly   463 PQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEE 527
            ..|::..|.||:|..  ..:.|  ..|.:.::|:|||||: .||||||.|...||  :.....:|
 Frog   241 SLGILSHHMYSVTGA--KQVQT--LHGSVSLLRVRNPWGH-TEWSGPWRDGGSEW--LSVINIKE 298

  Fly   528 IGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGC 592
            |.:....||||||..:||..:|..:|||:|.|:||:  |..|..|.||...:||.|...:::||.
 Frog   299 IEVENLEDGEFWMDVEDFQKNFQVLEICHLGPESLS--QIGSVARPWEYVTYEGCWLKDISSGGS 361

  Fly   593 RNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSK-RNVGIDCLTIGFAIYHLTDRD 656
            ....:.||.||||.:||. .:|.|.:..|:.||::|.|::|.| :::.:.|.     |:...:..
 Frog   362 IECKDHFWMNPQYTLSLV-TEDTDSNPMCSIIVSVMLKHKRLKAKDMRVMCY-----IFQGNEDH 420

  Fly   657 MQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRN 721
            :.:..:.|...:...||:...   ..||......||||.|:|:||....::||||:||:.:|..:
 Frog   421 VYLSQEILQCSQPVLSVSSCD---KKREAVLSTSLPPGRYIIIPSLETTSDEGEFLIRILTEKGS 482

  Fly   722 NMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSM 786
            :....|.:...||:   .|.|:   .|.:|....|..|      .:..|..:..:.|..:|...|
 Frog   483 SARPTDSKAACGES---AAQSV---RPTDEQCHSRFLL------FSDQDGRITNEGLHHLLTSLM 535

  Fly   787 RDVMVGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGSIDGFHL 851
            :|........:.::...::|.||....|.|.:|:|:.|..:|.....:|....:.:..::|...:
 Frog   536 KDFDPLLPEITMESCCRLIASLDTSAEGALCWEQFDRLWKNIITGSLIFSNLQSSKDRNLDKDQI 600

  Fly   852 RGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCAIKVRTFIEMFRERDTDNSDTAFFNLD 916
            ..||.|||...:|.|:..:..||..::|.:.:..|:.|.:|::....||...|:..|.|...|..
 Frog   601 GAALQSAGLITDNFLVRLVQLRYADKDGSLSYSAFICCLLKIKAVTGMFEVADSTGSGTVSLNYH 665

  Fly   917 DWLERTIYS 925
            .||:..:||
 Frog   666 QWLQLALYS 674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpBNP_524016.4 PHA03247 <40..207 CDD:223021
Peptidase_C2 260..556 CDD:459889 119/287 (41%)
Calpain_III 579..716 CDD:460050 43/137 (31%)
EFh_PEF_CalpA_B 758..925 CDD:320071 38/166 (23%)
EF-hand motif 758..786 CDD:320071 4/27 (15%)
EF-hand motif 799..829 CDD:320071 8/29 (28%)
EF-hand motif 830..860 CDD:320071 6/29 (21%)
EF-hand motif 866..894 CDD:320071 7/27 (26%)
EF-hand motif 895..925 CDD:320071 8/29 (28%)
capn12XP_031746547.1 Peptidase_C2 33..327 CDD:459889 119/287 (41%)
Calpain_III 348..476 CDD:460050 42/136 (31%)
EFh_PEF 507..674 CDD:355382 39/172 (23%)
EF-hand motif 507..535 CDD:320054 5/33 (15%)
EF-hand motif 549..578 CDD:320054 8/28 (29%)
EF-hand motif 579..608 CDD:320054 5/28 (18%)
EF-hand motif 615..643 CDD:320054 7/27 (26%)
EF-hand motif 645..673 CDD:320054 8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

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