DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn10

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_002935183.3	Gene:	capn10 / 100379827	XenbaseID:	XB-GENE-5770563	Length:	640	Species:	Xenopus tropicalis

Alignment Length:	508	Identity:	152/508 - (29%)
Similarity:	235/508 - (46%)	Gaps:	82/508 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 MFEDPDFPATNASLMY------SRRPDRYYEWLRPGDIADDPQFFVEGYSRFDV-QQGELGDCWL 316
            :|.|.||||..:||::      |...|. ..|.||.||...|..|.| .:|.:: :||.|||||.
Frog     8 LFVDSDFPAHVSSLVHGGDTQLSLHSDN-ISWQRPLDICASPSLFSE-KNRLNLGKQGILGDCWF 70

  Fly   317 LAAAANLTQDSTLFFRVIPPDQD--FQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHS 379
            :.|...|.:...|..:|.|..|.  ...||.|.|..:||::|.||||.|||.||....:|.:.|.
Frog    71 ICACTALQKYDRLLGQVFPAGQCTWTNSNYLGQFTCRFWRFGCWVEVTIDDNLPCLGNKLCFSHC 135

  Fly   380 TEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIK----EAPPNLFSIMMKA 440
            .::..||..|||||||||||.||||..|...:|:.|.|||:.|.:.::    .....|||.::..
Frog   136 QDQGAFWLPLLEKAYAKLHGCYEALWAGQVADALVDLTGGLVERWSLESEDDRGREKLFSKLVSL 200

  Fly   441 AERGSMMGCSLEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMIRMRNPWGNDAE 505
            .:|.:|....|.....|:|      |...|||:||.:  ..:.|.:.:..| ::|:.||||. :.
Frog   201 KDRCAMCCSVLHNRDRVME------LGELHAYTITDI--QHVVTKSCKDLL-LLRLHNPWGR-SS 255

  Fly   506 WSGPWSDSSPEWRFIPEHTKEEIGLNFD-RDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHS 569
            |:|.|......|..:  :.|:...|..: ::||||:..|:||..||.:.|      :.....:..
Frog   256 WAGSWRKGGDGWNDL--NLKDSARLLSEVQEGEFWVEKQEFLQEFDEITI------AFPYSHEGH 312

  Fly   570 SRRKW------EMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAIVALM 628
            .:..|      ....|.|.|..|.:|||.||.: :|..||::.:.:::|.:        ..::||
Frog   313 LQSIWTDLPLLHKQQFYGSWVKGYSAGGSRNNV-SFPENPKFWLRVKEPSE--------VFLSLM 368

  Fly   629 Q--------------KNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSP-- 677
            |              ..||:.|:.......:|..::.:..|.          ||.:.:::..|
Frog   369 QIPQGGVKIPEPVHGVYRRNLRHNKTAINAVGIHVWKVEKRR----------FKLQKTLSSLPLA 423

  Fly   678 ----HFINTR-EVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETRNNMEE 725
                |..:.: .:|.  .|.||:||::||.|....||.|::|:.|.....:.|
Frog   424 GTSSHCYDRQLHLCC--NLSPGYYLLIPSIFLREAEGNFLLRILSTGNFTLSE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	111/309 (36%)
		Calpain_III	574..721	CDD:279416	40/173 (23%)
		EF-hand_7	759..825	CDD:290234
		EFh	761..826	CDD:298682
		FRQ1	827..>908	CDD:227455
capn10	XP_002935183.3	Peptidase_C2	9..303	CDD:395523	110/307 (36%)
		calpain_III	324..473	CDD:214786	39/169 (23%)
		Calpain_III	493..624	CDD:412194
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110