Protein Alignment CalpB and capn9

DIOPT Version :10

• Sequence 1: NP_524016.4
• Gene: CalpB / 39165
• FlyBaseID: FBgn0025866
• Length: 925
• Species: Drosophila melanogaster
• Sequence 2: NP_001121483.1
• Gene: capn9 / 100158582
• XenbaseID: XB-GENE-948345
• Length: 691
• Species: Xenopus tropicalis
• Alignment Length: 684
• Identity: 319/684 - (46%)
• Similarity: 450/684 - (65%)
• Gaps: 29/684 - (4%)

  Fly   246 FQSLRDSCLANGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGE 310
            ::.|::.||..|.:|||.||||.::||.||.:|...:.|.||.::..||:|.:.|.||.||.||:
 Frog    29 YEQLKNDCLRKGVLFEDVDFPANDSSLFYSEKPSVPFVWKRPKEMVADPEFILGGASRTDVCQGD 93

  Fly   311 LGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELI 375
            |||||||||.|:||.:..:.:||:||||.|...|||||||:|||:.:|::|||||||||:...|:
 Frog    94 LGDCWLLAAIASLTLNDKILYRVVPPDQSFSTGYAGIFHFQFWQHNEWLDVVIDDRLPTFRNRLV 158

  Fly   376 YMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKA 440
            ::||.:.|||||||||||||||:|||||||||:|.||||||||||||.|:|:.||.|||.|:.||
 Frog   159 FVHSADLNEFWSALLEKAYAKLNGSYEALKGGSTLEAMEDFTGGVTETYEIRSAPANLFDILDKA 223

  Fly   441 AERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQG-KLPMIRMRNPWGND 503
            .::|||:|||:: ......||:|||||::|||||||...::     |.:| |:.:||:||||| .
 Frog   224 IKKGSMLGCSIDITSSAETEAKTPQGLVKGHAYSITGADVV-----NFKGQKVKLIRIRNPWG-Q 282

  Fly   504 AEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQH 568
            .||:|.|||:|.||..|....|..:......||||||.|:||..|||::|||||:||||.:|.:|
 Frog   283 VEWNGAWSDNSSEWNIIGAAEKNRLSQASLDDGEFWMDFEDFKRHFDKLEICNLTPDSLDDDAKH 347

  Fly   569 SSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDG--KCTAIVALMQKN 631
                |||:::.||.|..|.|||||||||||||.|||..:||    .|.|||  :||.|.||||||
 Frog   348 ----KWEVTVHEGSWIRGSTAGGCRNFLETFWSNPQIKLSL----TEQDDGQKECTFIAALMQKN 404

  Fly   632 RRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHY 696
            ||..|..|.|.||||:.||.....:..:..   :|||:..|.|||..::|.||:..|||||||.|
 Frog   405 RRKLRKTGADLLTIGYTIYQCPGSESILSK---DFFKFNPSKARSKTYVNLREISQRFKLPPGDY 466

  Fly   697 LIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRR 761
            :.:|:||:|::|.:|.:|:|||.:.:::|.|.||...      .|..|.|||..::..:....|.
 Frog   467 MFIPTTFEPHQEADFCLRIFSEKKADIKEMDGEVNID------LPDPPAPTPPHKETEEERQFRT 525

  Fly   762 LFDSVAGSDEEVDWQELKRILDHSMRDVM-VGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALL 825
            ||:.::|.|.||..:||:.:|:..:|... :.....|..:..::::::|...:|:|||:||:...
 Frog   526 LFEQISGQDLEVSAEELQYVLNAVLRRTKNIKFKEMSLLSCNNIISLMDASGNGKLGFDEFKIFW 590

  Fly   826 TDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCA 890
            ..:..|..:|..||..::|::..:.||.||.|||:||||.:|..:..||...:.||.|||||.|.
 Frog   591 DKLKTWIGIFMQYDLDKSGTMSSYELRLALKSAGFHLNNIVLQLIVLRYADDQFQIEFDDFLNCL 655

  Fly   891 IKVRTFIEMFRERD-TDNSDTAFFNLDDWLERTI 923
            :::.....:|::.: :|.::|...|..:::..|:
 Frog   656 VRLENSYRVFKQLNRSDTTETIQLNQAEFIALTM 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_524016.4	PHA03247	<40..207	CDD:223021
		Peptidase_C2	260..556	CDD:459889	169/297 (57%)
		Calpain_III	579..716	CDD:460050	71/138 (51%)
		EFh_PEF_CalpA_B	758..925	CDD:320071	51/168 (30%)
		EF-hand motif	758..786	CDD:320071	10/27 (37%)
		EF-hand motif	799..829	CDD:320071	7/29 (24%)
		EF-hand motif	830..860	CDD:320071	11/29 (38%)
		EF-hand motif	866..894	CDD:320071	11/27 (41%)
		EF-hand motif	895..925	CDD:320071	5/30 (17%)
capn9	NP_001121483.1	Peptidase_C2	43..335	CDD:459889	169/297 (57%)
		Calpain_III	347..496	CDD:238132	78/159 (49%)
		EFh_PEF_CAPN9	522..691	CDD:320067	51/168 (30%)
		EF-hand motif	522..550	CDD:320067	10/27 (37%)
		EF-hand motif	565..594	CDD:320067	7/28 (25%)
		EF-hand motif	595..625	CDD:320067	11/29 (38%)
		EF-hand motif	631..659	CDD:320067	11/27 (41%)
		EF-hand motif	661..691	CDD:320067	5/29 (17%)