DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn9

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001121483.1	Gene:	capn9 / 100158582	XenbaseID:	XB-GENE-948345	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	684	Identity:	319/684 - (46%)
Similarity:	450/684 - (65%)	Gaps:	29/684 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 FQSLRDSCLANGTMFEDPDFPATNASLMYSRRPDRYYEWLRPGDIADDPQFFVEGYSRFDVQQGE 310
            ::.|::.||..|.:|||.||||.::||.||.:|...:.|.||.::..||:|.:.|.||.||.||:
Frog    29 YEQLKNDCLRKGVLFEDVDFPANDSSLFYSEKPSVPFVWKRPKEMVADPEFILGGASRTDVCQGD 93

  Fly   311 LGDCWLLAAAANLTQDSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELI 375
            |||||||||.|:||.:..:.:||:||||.|...|||||||:|||:.:|::|||||||||:...|:
Frog    94 LGDCWLLAAIASLTLNDKILYRVVPPDQSFSTGYAGIFHFQFWQHNEWLDVVIDDRLPTFRNRLV 158

  Fly   376 YMHSTEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPNLFSIMMKA 440
            ::||.:.|||||||||||||||:|||||||||:|.||||||||||||.|:|:.||.|||.|:.||
Frog   159 FVHSADLNEFWSALLEKAYAKLNGSYEALKGGSTLEAMEDFTGGVTETYEIRSAPANLFDILDKA 223

  Fly   441 AERGSMMGCSLE-PDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQG-KLPMIRMRNPWGND 503
            .::|||:|||:: ......||:|||||::|||||||...::     |.:| |:.:||:||||| .
Frog   224 IKKGSMLGCSIDITSSAETEAKTPQGLVKGHAYSITGADVV-----NFKGQKVKLIRIRNPWG-Q 282

  Fly   504 AEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQH 568
            .||:|.|||:|.||..|....|..:......||||||.|:||..|||::|||||:||||.:|.:|
Frog   283 VEWNGAWSDNSSEWNIIGAAEKNRLSQASLDDGEFWMDFEDFKRHFDKLEICNLTPDSLDDDAKH 347

  Fly   569 SSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDG--KCTAIVALMQKN 631
                |||:::.||.|..|.|||||||||||||.|||..:||    .|.|||  :||.|.||||||
Frog   348 ----KWEVTVHEGSWIRGSTAGGCRNFLETFWSNPQIKLSL----TEQDDGQKECTFIAALMQKN 404

  Fly   632 RRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFINTREVCARFKLPPGHY 696
            ||..|..|.|.||||:.||.....:..:..   :|||:..|.|||..::|.||:..|||||||.|
Frog   405 RRKLRKTGADLLTIGYTIYQCPGSESILSK---DFFKFNPSKARSKTYVNLREISQRFKLPPGDY 466

  Fly   697 LIVPSTFDPNEEGEFIIRVFSETRNNMEENDDEVGFGETDDRIAPSLPPPTPKEEDDPQRIALRR 761
            :.:|:||:|::|.:|.:|:|||.:.:::|.|.||...      .|..|.|||..::..:....|.
Frog   467 MFIPTTFEPHQEADFCLRIFSEKKADIKEMDGEVNID------LPDPPAPTPPHKETEEERQFRT 525

  Fly   762 LFDSVAGSDEEVDWQELKRILDHSMRDVM-VGSDGFSKDAVRSMVAMLDKDRSGRLGFEEFEALL 825
            ||:.::|.|.||..:||:.:|:..:|... :.....|..:..::::::|...:|:|||:||:...
Frog   526 LFEQISGQDLEVSAEELQYVLNAVLRRTKNIKFKEMSLLSCNNIISLMDASGNGKLGFDEFKIFW 590

  Fly   826 TDIAKWRAVFKLYDTRRTGSIDGFHLRGALNSAGYHLNNRLLNALAHRYGSREGQIPFDDFLMCA 890
            ..:..|..:|..||..::|::..:.||.||.|||:||||.:|..:..||...:.||.|||||.|.
Frog   591 DKLKTWIGIFMQYDLDKSGTMSSYELRLALKSAGFHLNNIVLQLIVLRYADDQFQIEFDDFLNCL 655

  Fly   891 IKVRTFIEMFRERD-TDNSDTAFFNLDDWLERTI 923
            :::.....:|::.: :|.::|...|..:::..|:
Frog   656 VRLENSYRVFKQLNRSDTTETIQLNQAEFIALTM 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403
		Drf_FH1	37..189	CDD:283903
		Peptidase_C2	260..556	CDD:279042	169/297 (57%)
		Calpain_III	574..721	CDD:279416	76/148 (51%)
		EF-hand_7	759..825	CDD:290234	19/66 (29%)
		EFh	761..826	CDD:298682	18/65 (28%)
		FRQ1	827..>908	CDD:227455	29/81 (36%)
capn9	NP_001121483.1	Peptidase_C2	43..335	CDD:366222	169/297 (57%)
		Calpain_III	356..491	CDD:366446	73/141 (52%)
		EFh_PEF_CAPN9	522..691	CDD:320067	51/168 (30%)
		EF-hand motif	522..550	CDD:320067	10/27 (37%)
		EF-hand motif	565..594	CDD:320067	7/28 (25%)
		EF-hand motif	595..625	CDD:320067	11/29 (38%)
		EF-hand motif	631..659	CDD:320067	11/27 (41%)
		EF-hand motif	661..691	CDD:320067	5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I950
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H38208
Inparanoid	1	1.050	643	1.000	Inparanoid score	I801
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm9483
Panther	1	1.100	-	-	O	PTHR10183
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160