DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpB and capn15

DIOPT Version :9

Sequence 1:	NP_001246706.1	Gene:	CalpB / 39165	FlyBaseID:	FBgn0025866	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_031748342.1	Gene:	capn15 / 100127702	XenbaseID:	XB-GENE-5926484	Length:	1051	Species:	Xenopus tropicalis

Alignment Length:	1019	Identity:	235/1019 - (23%)
Similarity:	354/1019 - (34%)	Gaps:	324/1019 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PKPKAGLYPSLPYPSSESVGGMPYVVKQTSHAQNASYAGPTMGMGMP------------------ 87
            |.|.....|.:|:..:.|.|..|...:.|  |...|..|.|.|...|
Frog   137 PSPVPNGLPGIPHAETGSSGQGPEPSEGT--ASILSTTGVTPGWSCPRCTLHNTPVSTSCSACGG 199

  Fly    88 ---------VPEAPSAPAPYPSATPYPGSGLYPSLP-SANVSSLPYPTAPMAPYPTGMPYPTGMP 142
                     .|||...|...|....:.||....:.| ....||.|.|:.|::|.|...|.|....
Frog   200 PRKLSLPKIPPEALVVPEIVPPPAAFQGSEEPGTAPLREQDSSRPLPSLPLSPGPHNAPVPRSRR 264

  Fly   143 QPNLPYPAAPLAPYPSAMPGLP--------GMP-MPYAPMPTSP--------------------- 177
            :   ..|..||:|..|....||        .|| ...||.||.|
Frog   265 E---VAPDNPLSPSTSGPIRLPKRLSVLEEEMPTAEQAPTPTEPYSPDSRWACGKCTLRNIPTAS 326

  Fly   178 ------APQHNIGFP------ALPYP--TAPPPESAP--TQEEEPSV------GVAELSFTSVK- 219
                  |.:.|.|.|      |||.|  |...|.|||  ||...|:.      ||...:.....
Frog   327 RCRACGAVRGNDGEPGMGGLDALPSPSSTGLLPVSAPRKTQWACPACTLLNDNGVTHCAACHTPQ 391

  Fly   220 --VPENQNMFWMGRKATSAR---QNSVSKGDFQSLRDSCLA-------------NGTMFEDPDFP 266
              :.::.....:.|:..|.|   :....:|:.:.|.::.::             |...|.|..||
Frog   392 RYITQHHMKTRVLRRRESVRAETRRQTDEGEAKELWENIVSFCRDLSSYLSPSQNTVNFVDDSFP 456

  Fly   267 ATNASLMYSRRPD---RYYEWLRPGDIADDPQFFVEGYSRF---------DVQQGELGDCWLLAA 319
            ....|:.:.....   |..:||||.:|  :...|.|...::         |:.||.||:||.|:|
Frog   457 PGPRSVGFPETDSVQLRVKQWLRPQEI--NCSSFKERSVKWTVFRTPRPSDILQGLLGNCWFLSA 519

  Fly   320 AANLTQ-----DSTLFFRVIPPDQDFQENYAGIFHFKFWQYGKWVEVVIDDRLPTYNGELIYMHS 379
            .|.|.:     :..:..|.|.|:        |.:..:..:.|.|..|::||.||......:....
Frog   520 LAVLAERPELVERVMITRTICPE--------GAYQVRLCKDGTWTTVLVDDMLPCDEAGYLLFSQ 576

  Fly   380 TEKNEFWSALLEKAYAKLHGSYEALKGGTTCEAMEDFTGGVTEWYDIKEAPPN----------LF 434
            .::.:.|.||:|||.|||||||.||:.|...|.:...||...|...::.:..|          ::
Frog   577 AQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLMLQVSSTNPREENVDTDLIW 641

  Fly   435 SIMMKAAERGSMMGCS-----LEPDPHVLEAETPQGLIRGHAYSITKVCLMDISTPNRQGKLPMI 494
            :.|:.:.|.|.:||.|     ::.|....|   ..||...|||||..|  .|:     || ..::
Frog   642 AKMLSSKEAGFLMGASCGGGNMKVDDIAYE---NVGLRPRHAYSILDV--RDV-----QG-FRLL 695

  Fly   495 RMRNPWGNDAEWSGPWSDSSPEWRFIPEHTKEEIGLNFDRDGEFWMSFQDFLNHFDRVEICNLSP 559
            |:|||||. ..|:|.|||   ||...|...|.|:..:...:|.|||.:.||:.:||.|:||.:..
Frog   696 RLRNPWGR-FSWNGSWSD---EWSQWPASLKHELMPHGSSEGVFWMEYNDFIRYFDSVDICKIHT 756

  Fly   560 DSLTEDQQHSSRRKWEMSMFEGEWTSGVTAGGCRNFLETFWHNPQYIISLEDPDDEDDDGKCTAI 624
            |             |.....:|.:.:..:.             |..:.||...:.       ||:
Frog   757 D-------------WHEVRVQGTFPNKASV-------------PVTVTSLTVVER-------TAM 788

  Fly   625 -VALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQVKPQGLNFFKYRASVARSPHFI------NT 682
             .:|.|:.  |:|:..:|.        ||.|..:.|         :|||.:.|...:      ::
Frog   789 EFSLFQEG--SRRSDTVDS--------HLLDLCIMV---------FRASHSGSGKVMLGRLMAHS 834

  Fly   683 REVCARF-----KLPPGHYLIVPSTFDPNE----EGEFIIRVFSET--RNNMEENDDEVGFGETD 736
            :....:|     .|.||.|.:|...|:..:    .|....:..|.|  .||.....|.:|:
Frog   835 KRAVKKFVGCDVMLEPGEYAVVCCAFNHWQTLMAAGSSPAQASSPTGSSNNRRAASDALGY---- 895

  Fly   737 DRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILD-HSMRDVMVGSDGFSKDA 800
                                                        ||. :|.|.|||.........
Frog   896 --------------------------------------------ILAIYSSRLVMVEQVEAQPTT 916

  Fly   801 VRSMVAMLDKDR----SGRLGFEEFEALLTDIAKWRAVFKLYDTRRTGS--------IDGFHL-- 851
            :...:.:|.:|:    .||.|...:  .||.  .|..:..:.:.|...|        .|.|::
Frog   917 LADAIILLTEDKGERHEGREGMTCY--YLTH--GWAGLIVVVENRHPKSYLHIQCDCTDSFNVVS 977

  Fly   852 -RGAL---------------------NSAGYHLNNRLLNALAHR 873
             ||.|                     .:||:.:.:|    ||||
Frog   978 TRGCLKTSDSVPPLHRQVLVILSQLEGNAGFSITHR----LAHR 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpB	NP_001246706.1	PD-C2-AF1	33..225	CDD:286403	63/266 (24%)
		Drf_FH1	37..189	CDD:283903	50/217 (23%)
		Peptidase_C2	260..556	CDD:279042	101/327 (31%)
		Calpain_III	574..721	CDD:279416	30/164 (18%)
		EF-hand_7	759..825	CDD:290234	12/70 (17%)
		EFh	761..826	CDD:298682	12/69 (17%)
		FRQ1	827..>908	CDD:227455	15/79 (19%)
capn15	XP_031748342.1	RanBP2-type Zn finger	67..86	CDD:275375
		RanBP2-type Zn finger	107..132	CDD:275375
		PHA03247	<140..390	CDD:223021	61/254 (24%)
		RanBP2-type Zn finger	178..197	CDD:275375	1/18 (6%)
		RanBP2-type Zn finger	255..274	CDD:275375	5/21 (24%)
		RanBP2-type Zn finger	312..331	CDD:275376	0/18 (0%)
		RanBP2-type Zn finger	368..387	CDD:275376	3/18 (17%)
		Peptidase_C2	450..753	CDD:395523	101/327 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010