Protein Alignment Taf2 and TAF2

DIOPT Version :10

• Sequence 1: NP_729571.1
• Gene: Taf2 / 39164
• FlyBaseID: FBgn0011836
• Length: 1221
• Species: Drosophila melanogaster
• Sequence 2: NP_001424267.1
• Gene: TAF2 / 6873
• HGNCID: 11536
• Length: 1251
• Species: Homo sapiens
• Alignment Length: 1282
• Identity: 575/1282 - (44%)
• Similarity: 795/1282 - (62%)
• Gaps: 130/1282 - (10%)

  Fly    13 RPFKLAHQVVSLTGISFERRSIIGVVELTIVPNSENLRLIRLNAKQLRIYSVVLNDVCQADFTYF 77
            ||:||.||||.:..|:|:|:|::|.|||||.|...||..|:||:||.|||.|.:||: :|.|.|.
Human    24 RPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVRINDL-EAAFIYN 87

  Fly    78 DPFQNICYKEHKSRALEVYSKHHLTAAQYTDPDVNNGELLIQVPPEGYSMIQEGQGLRIRIEFSL 142
            ||...:|:.|.|.|.|..:|..:..|....|||..||||.|:||.|.:..:.|.:.|:|.|.|||
Human    88 DPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPDAGNGELCIKVPSELWKHVDELKVLKIHINFSL 152

  Fly   143 ENPKCGVHFVIPPASTDEETQMNSSHMFTNCYENSSRLWFPCVDSFADPCTWRLEFTVDKNMTAV 207
            :.||.|:|||:|  |.:.......:|:|:..|:||:|.|||||||:::.|||:||||||..|.||
Human   153 DQPKGGLHFVVP--SVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAV 215

  Fly   208 SCGELLEVIMTPDLRKKTFHYSVSTPVCAPNIALAVGQFEIYVDPHMHEVTHFCLPGLLPLLKNT 272
            |.|:|:|.:.|.|:|||||||.::.|..|.||:||:|.|||.|||:||||||||||.||||||:|
Human   216 SNGDLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHT 280

  Fly   273 VRYLHEAFEFYEETLSTRYPFSCYKQVFVDELDTDISAYATMSIASVNLLHSIAIIDQTYISRTF 337
            ..||||.||||||.|:.|||:||:|.||:||...:::|||:|||.|.|||||..|||:|.::|..
Human   281 TSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRC 345

  Fly   338 MSRAVAEQFFGCFITSHHWSDTWLAKGIAEYLCGLYSRKCFGNNEYRAWVQSELARVVRYEEQYG 402
            :::::|:|||||||:...|||.|:.|||:.|:.||:.:|.||.||||.|::.||.::|.||.:.|
Human   346 LAQSLAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTG 410

  Fly   403 GIILDCSQPPAPLPVSGTNQSAASSKQQEIVH-YFPIKSLHTVSPKYVEAMRRKAHFVIRMLENR 466
            |::|.        |:.|    ....|.....| :|.||..||:|.:|....:.|||.|:|::|||
Human   411 GVLLH--------PIFG----GGKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENR 463

  Fly   467 IGQELLIQVFNKQLALASSAATTKIGAGLWSQLLISTNIFIKAIFTVTGKDMSVFMDQWVRTGGH 531
            |..|.::|||||.|:|||:|::.|..:.:|||:|:||:.|:|:|..|:|||:...:.|||...|.
Human   464 ISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQSGV 528

  Fly   532 AKFSLTSVFNRKRNTIELEIRQDYVNQRGIRKYNGPLMVQLQELDGTFKHTLQIESTLVKSDITC 596
            .||..:..||||||.:||||:|||.:. |.:||.|||.|.:|||||:|.||||||...:|.||.|
Human   529 VKFYGSFAFNRKRNVLELEIKQDYTSP-GTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPC 592

  Fly   597 HSKSRRNKKKKIPLCTGEEVDMDLSAMD-DSPVLWIRLDPEMILLRDLIIEQPDFQWQYQLRHER 660
            ||||||||||||||..|||||||||||| |||:||||:||:|.:||.:..||.||.||||||:||
Human   593 HSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYER 657

  Fly   661 DVTAQFQAIQALQKYPTNATRLALTDTIESERCFYQVRCEAAHSLTKVANQMVASWSGPPAMLNI 725
            ||.||.::|.||:|:||.|:||||||.:|.|:|||:||..|...|.|:||.||::|:|||||.::
Human   658 DVVAQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSL 722

  Fly   726 FRKFFGSFSAPHIIKLNNFSNFQLYFLQKAIPVAMAGLRTSHGICPPEVMRFLFDLFKYNENSRN 790
            |.:.|...|.|:|:|.|||.:||.|||||.:|||||.||..|.:||.||:.|:.||.|||:|.:|
Human   723 FTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIKYNDNRKN 787

  Fly   791 HYTDAYYRAALVEALGETLTPVVSVAIHGTQITTDSLSTDAKLVLDEVTRLLNMEKHLPSYKYMV 855
            .::|.||||.:::||..::||.|||  :....|.|:|:.|.:|:|:|:||.|||||.||||::.:
Human   788 KFSDNYYRAEMIDALANSVTPAVSV--NNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTI 850

  Fly   856 SVSCLKVIRKLQKFGHLPSLPHIYRSYAEYGIYLDLRIAAMECLVDFVKVDGRSEDLEHLITLLE 920
            :||||:.||.|||.||:||.|.:::||||||.::|:||||:|.:||:.|||...|:|:.|:.:::
Human   851 TVSCLRAIRVLQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQ 915

  Fly   921 TDPDPAARHALAQLLIDNPPFTRESRSRLDKPNLVDRLWFSINR-LPYDTKLRCDIVDLYYALYG 984
            .||.|..||.:..:|..|||||:...|.|....|||:||..:|. ..:|.:|||..||||:.|:|
Human   916 NDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSHDWRLRCGAVDLYFTLFG 980

  Fly   985 TKRPNCL-------------------------------QAGENQSFYKDLM-----------KDN 1007
            ..||:||                               :|..|.|.:..|:           |:.
Human   981 LSRPSCLPLPELGLVLNLKEKKAVLNPTIIPESVAGNQEAANNPSSHPQLVGFQNPEDDHLAKEA 1045

  Fly  1008 NSSVGSVTGSFKKTSDSKSHLP-TPTNTLD-NEPQERQKPAMVTIKRTATEAFEVGDEIIKLER- 1069
            :.::.:.....|:.||:....| .|...|: ||...:.|   :.|:.::::    .:|.|.::.
Human  1046 SCNISAHQQGVKRKSDTPLGSPLEPGQILEKNEDSSKVK---LKIRFSSSQ----DEEEIDMDTV 1103

  Fly  1070 -------SEEITVLDEP--VNVQAYDSETKVNALQADEEA------------------RDTHQAA 1107
                   |..:.:|:.|  ..:..|...:..:||.....|                  :.|.:..
Human  1104 HDSQAFISHHLNMLERPSTPGLSKYRPASSRSALIPQHSAGCDSTPTTKPQWSLELARKGTGKEQ 1168

  Fly  1108 KRLKNEMYAEDDNSSTMLDVGDSTRYESSHEEGKLKSGDGGLKKKKKKEKKKHKHKHKHRHSKDK 1172
            ..|:..|:..   :|..|.|.......|.|.:.....     ..:.||:||||||||||:|..|
Human  1169 APLEMSMHPA---ASAPLSVFTKESTASKHSDHHHHH-----HHEHKKKKKKHKHKHKHKHKHD- 1224

  Fly  1173 DKDKDKERKDKDKRDPHISRLQARETATPDTLSSEDSSNSNSLPPMN 1219
            .|:||||                     |.|.||..|..|...|.::
Human  1225 SKEKDKE---------------------PFTFSSPASGRSIRSPSLS 1250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Taf2	NP_729571.1	M1_like_TAF2	17..526	CDD:341074	253/509 (50%)
TAF2	NP_001424267.1	None