DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iPLA2-VIA and PLA2G6

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001336793.1	Gene:	PLA2G6 / 8398	HGNCID:	9039	Length:	806	Species:	Homo sapiens

Alignment Length:	871	Identity:	307/871 - (35%)
Similarity:	460/871 - (52%)	Gaps:	118/871 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LFAPPF----------NSSNEKRAVYEIILQRPTSD-----------SNTTSFSLYRSPVQQEAE 93
            ||:.||          .||:..|...::||.:.|.:           ::.:.|.|::..::.:|.
Human    17 LFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADAL 81

  Fly    94 ERFNAFLQRLPVFVSIVKEYYNVNGLQKACDALADNPSWTLSHLIAYFNLVDYISNPKMLQCVDQ 158
            ..|:.:..:|..|.....:..:...||...|.:.::|||:::||.....:.:...:.:::.|.:.
Human    82 VNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANC 146

  Fly   159 ADAATLMSPFQLAIKQGHMEMVKALLPL--SKLEHLDINSNSVFHYAA-STTKEIINLIIDKSTV 220
            |:.....:|..||.::|..|::..|:..  ::::..|....:|||||. ....:::.|:...:..
Human   147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211

  Fly   221 NLNHLNSDGYTPLHVACLADKPENVKALLLAGANVNL---NAKDIRKVYKTSAPTTVSSFLRTNV 282
            .||.:|:.|.||||:||...|.|.|:.|||..|..|:   |...|....|.|........:..:.
Human   212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDS 276

  Fly   283 SKLYTQDMKYGGTPLHWCSSRETLHALIMEGCDVNATNFDGRTALHVMVARNRFECVVTLLAHDA 347
            |:::::|.:||.:||||..:.|....|:..||:||:|:..|.|||||.|.||||:|.:.||.|.|
Human   277 SQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGA 341

  Fly   348 EIDVLDKDGNAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDEILYIL 412
            ..|...:.||..||:|:.|..|.:::.|:|||.:::..|..|:||..:............||.:|
Human   342 NADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLL 406

  Fly   413 HSVGAKRCKDTGSKCPPGCNAKGNYNGIPPE----APESVEQREHIEHMLATTSRQMMGGFLNAA 473
            .:|||:.|      .||       .:|:|.|    ||         .|..:
Human   407 RTVGAEYC------FPP-------IHGVPAEQGSAAP---------HHPFS-------------- 435

  Fly   474 ANGILEKQQPAQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKENSSDSLASGSQKSAVSS 538
                ||:.||  .|:.::   .|:.|.:|.                        .|.::|.|.
Human   436 ----LERAQP--PPISLN---NLELQDLMH------------------------ISRARKPAF-- 465

  Fly   539 PEQLPSPTSPIAAEIGDKPYGRGRLLCLDGGGIRGLVLVQMLLEIEKLSRTPIIHMFDWIAGTST 603
                      |...:.|:......||||||||::||:::|:|:.|||.|......:|||:|||||
Human   466 ----------ILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTST 520

  Fly   604 GGILALALGCGKTMRQCMGLYLRMKEQCFVGSRPYNSEFFESILKDNLGEFNVMTDIKHPKIMVT 668
            |||||||:...|:|....|:|.|||::.|.|||||.|...|..||...||...|||::.||:|:|
Human   521 GGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLT 585

  Fly   669 GVMADRKPVDLHLFRNYTSASDILGIVTPINNRRI---PPPQPSEQLVWRAARATGAAPSYFRAF 730
            |.::||:|.:|||||||.:...:.   .|..|:.:   ||.|||:||||||||::||||:|||..
Human   586 GTLSDRQPAELHLFRNYDAPETVR---EPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPN 647

  Fly   731 GRFLDGGLIANNPTLDAMTEIHEYNMALRSAGRESEAIPVSVVMSLGTGHIPVTELKDIDVFRPE 795
            ||||||||:||||||||||||||||..|...|:.::...:|:|:|||||..|...:..:|||||.
Human   648 GRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPS 712

  Fly   796 SIWDTAKLAYGISTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQLSEDIAMDEKDDQK 860
            :.|:.||..:|...:|.::||..|..|||.||||||||..:||.|||.||||..||.:||..|..
Human   713 NPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTV 777

  Fly   861 LINMLWHTKAYMHANRNKIIEMINFL 886
            |:|.||.|:.|::.:|.:..::|..|
Human   778 LVNALWETEVYIYEHREEFQKLIQLL 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786	15/62 (24%)
		Ank_2	168..258	CDD:289560	30/95 (32%)
		ANK	191..343	CDD:238125	56/155 (36%)
		ANK repeat	228..261	CDD:293786	16/35 (46%)
		ANK	291..412	CDD:238125	47/120 (39%)
		ANK repeat	292..320	CDD:293786	12/27 (44%)
		Ank_2	297..386	CDD:289560	38/88 (43%)
		ANK repeat	322..353	CDD:293786	17/30 (57%)
		ANK repeat	355..386	CDD:293786	11/30 (37%)
		ANK repeat	388..417	CDD:293786	7/28 (25%)
		Pat_PNPLA9	563..876	CDD:132851	168/315 (53%)
PLA2G6	NP_001336793.1	ANK	<103..172	CDD:238125	15/68 (22%)
		ANK repeat	118..149	CDD:293786	7/30 (23%)
		ANK 1. /evidence=ECO:0000250\|UniProtKB:A0A3L7I2I8	120..147		4/26 (15%)
		ANK	147..272	CDD:238125	36/124 (29%)
		ANK repeat	151..183	CDD:293786	6/31 (19%)
		ANK 1. /evidence=ECO:0000255	151..181		6/29 (21%)
		ANK repeat	185..217	CDD:293786	8/31 (26%)
		ANK 2. /evidence=ECO:0000255	185..215		7/29 (24%)
		ANK repeat	219..248	CDD:293786	14/28 (50%)
		ANK 3. /evidence=ECO:0000255	219..248		14/28 (50%)
		ANK 4. /evidence=ECO:0000255	251..281		5/29 (17%)
		ANK	285..403	CDD:238125	45/117 (38%)
		ANK repeat	286..314	CDD:293786	12/27 (44%)
		ANK 5. /evidence=ECO:0000255	286..312		11/25 (44%)
		ANK repeat	316..347	CDD:293786	17/30 (57%)
		ANK 6. /evidence=ECO:0000255	316..345		16/28 (57%)
		ANK repeat	349..380	CDD:293786	11/30 (37%)
		ANK 7. /evidence=ECO:0000255	349..378		11/28 (39%)
		ANK 9. /evidence=ECO:0000250\|UniProtKB:A0A3L7I2I8	382..403		3/20 (15%)
		Pat_PNPLA9	480..793	CDD:132851	168/315 (53%)
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	485..490		3/4 (75%)
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	517..521		3/3 (100%)
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	652..654		1/1 (100%)
		Calmodulin-binding (1-9-14 motif). /evidence=ECO:0000250\|UniProtKB:A0A3L7I2I8	677..686		1/8 (13%)
		Calmodulin-binding (IQ motif). /evidence=ECO:0000250\|UniProtKB:A0A3L7I2I8	748..759		6/10 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156346
Domainoid	1	1.000	217	1.000	Domainoid score	I2692
eggNOG	1	0.900	-	-		E1_COG3621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2635
Inparanoid	1	1.050	554	1.000	Inparanoid score	I1117
Isobase	1	0.950	-	0	Normalized mean entropy	S4470
OMA	1	1.010	-	-		QHG49455
OrthoDB	1	1.010	-	-		D362279at33208
OrthoFinder	1	1.000	-	-		FOG0005157
OrthoInspector	1	1.000	-	-		oto91637
orthoMCL	1	0.900	-	-		OOG6_104994
Panther	1	1.100	-	-	LDO	PTHR24139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5526
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720