Protein Alignment iPLA2-VIA and pla2g6

DIOPT Version :10

• Sequence 1: NP_729565.2
• Gene: iPLA2-VIA / 39160
• FlyBaseID: FBgn0036053
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: XP_012816940.2
• Gene: pla2g6 / 780118
• XenbaseID: XB-GENE-920447
• Length: 801
• Species: Xenopus tropicalis
• Alignment Length: 888
• Identity: 293/888 - (32%)
• Similarity: 440/888 - (49%)
• Gaps: 140/888 - (15%)

  Fly    27 KVVEIKSEALGTLQVLARDDAMLLFAPPFNSSNEKRAVYEIILQRPTSDSNTTSFSLYRSPVQQE 91
            ||.|:.....|....:..|..:||:      .|......:.:|..|.|..|  ::.|::...:.|
 Frog    23 KVREVPLSEYGNCSCIQEDGRVLLY------RNRTAKSLDCVLVNPISPQN--AYRLFQLDSEHE 79

  Fly    92 AEERFNAFLQRLPVFVSIVKEYYNVNGLQKACDALADNPSWTLSHLIAYFNLVDYISNPKMLQCV 156
            |..||..:..:|..|....::...:..:|:..|.:..:|:|:|:|:.....|.:...:..:|:.:
 Frog    80 ALLRFQEYAVKLRPFYESSRKGLRLETIQQLTDCIRSHPNWSLAHVAVDIGLRESFKHNGILRSL 144

  Fly   157 DQADAATLMSPFQLAIKQGHMEMVKALLP--LSKLEHLDINSNSVFHYAA-STTKEIINLIIDKS 218
            :..|.....:|..||.|:|.:|.::.|:.  .::.:..|.|..:|:|:|| .....:|.::....
 Frog   145 NSTDCDGGSTPLHLACKKGDIECLQELVEECQARQDIADQNGETVYHHAAQQNNPRVIEILCSVP 209

  Fly   219 TVNLNHLNSDGYTPLHVACLADKPENVKALLLAGANVNLNAKD---IRKVYKTSAPTTVSSFLRT 280
            :|.:||.:::...||||||...|.|:|.|||...|..::..||   |....|.|......:.|..
 Frog   210 SVGINHQSNNNEAPLHVACRMGKTESVLALLRCQARCDIIGKDGYPIHTAMKYSQNGCAEAILDV 274

  Fly   281 NVSKLYTQDMKYGGTPLHWCSSRETLHALIMEGCDVNATNFDGRTALHVMVARNRFECVVTLLAH 345
            :.::|:.:|.:|..||:||..:.|....||..||.||..:....|.||:||.|:|||..:.||.:
 Frog   275 SANQLHAEDPRYQATPIHWAKNAEMARLLIQRGCKVNTRSKTSDTPLHIMVKRDRFEAAMVLLTN 339

  Fly   346 DAEIDVLDKDGNAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDEILY 410
            .|:.:...:.||..||:|::|..:.:::.|:|||.|:...|..|:||..:....:.||....:|.
 Frog   340 GADPNAKGEHGNTPLHLAMKKDHLELIKALMVFGADVEQHNDFGETPGLIAARSSKGNNRKVLLS 404

  Fly   411 ILHSVGAKRCKDTGSKCPPGCNAKGNYNGIPPE--------APESVEQREHIE----HMLATTSR 463
            :|.:|||:||                   :||:        :|.||...:...    |.|.
 Frog   405 MLCNVGAERC-------------------LPPDTQLLPTATSPSSVPPSDRSSGIGFHDLV---- 446

  Fly   464 QMMGGFLNAAANGILEKQQPAQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKENSSDSLA 528
                 :::.|.:|:|..|.      .||..::  |..:.|
 Frog   447 -----YVSTALSGMLVPQD------TVDFRED--GLRVKD------------------------- 473

  Fly   529 SGSQKSAVSSPEQLPSPTSPIAAEIGDKPYGRGRLLCLDGGGIRGLVLVQMLLEIEKLSRTPIIH 593
                                             |||||||||||||||:|:|:.|||.:..||..
 Frog   474 ---------------------------------RLLCLDGGGIRGLVLIQLLIAIEKAAGRPIRE 505

  Fly   594 MFDWIAGTSTGGILALALGCGKTMRQCMGLYLRMKEQCFVGSRPYNSEFFESILKDNLGEFNVMT 658
            :|||::|||||||||||:..|..|.....||.|||.:.|.|||||.|...|..||...||...|:
 Frog   506 LFDWVSGTSTGGILALAIVHGMPMEYVRCLYFRMKNEVFHGSRPYESGPLEEFLKREFGENTKMS 570

  Fly   659 DIKHPKIMVTGVMADRKPVDLHLFRNYTSASDILGIVTPINNRRIPP----------PQPSEQLV 713
            |:::||::|||.::||.|.:|||||||          .|......||          ..|:||||
 Frog   571 DVRNPKVIVTGTLSDRHPAELHLFRNY----------DPPETDHEPPYKSVASFRPVTAPAEQLV 625

  Fly   714 WRAARATGAAPSYFRAFGRFLDGGLIANNPTLDAMTEIHEYNMALRSAGRESEAIPVSVVMSLGT 778
            |||||::||||:|.|..||||||||::||||||||||:|:||..|:..|...:...:.:|:||||
 Frog   626 WRAARSSGAAPTYLRPMGRFLDGGLLSNNPTLDAMTEMHQYNNCLKKKGMAGQVKKLGIVVSLGT 690

  Fly   779 GHIPVTELKDIDVFRPESIWDTAKLAYGISTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRF 843
            |..|...:..:|||||.:.|:..|...|...:|.::||..|.|||..|.||||||..|.:||||.
 Frog   691 GKPPQISVSSVDVFRPSNPWEMMKTVVGARELGKMVVDCCTDSDGPAVSRARAWCEMIDVPYFRL 755

  Fly   844 NPQLSEDIAMDEKDDQKLINMLWHTKAYMHANRNKIIEMINFL 886
            :|||..|:.:||.:|..|:||||.|:.|::..|..:..:...|
 Frog   756 SPQLQTDVMLDEVNDAVLVNMLWDTQIYIYQQREVLQRLAKIL 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANKYR	143..418	CDD:440430	86/280 (31%)
		ANK repeat	166..226	CDD:293786	17/62 (27%)
		ANK repeat	228..261	CDD:293786	13/32 (41%)
		ANK repeat	292..320	CDD:293786	12/27 (44%)
		ANK repeat	322..353	CDD:293786	12/30 (40%)
		ANK repeat	355..386	CDD:293786	11/30 (37%)
		ANK repeat	388..417	CDD:293786	8/28 (29%)
		Pat_PNPLA9	563..876	CDD:132851	161/322 (50%)
pla2g6	XP_012816940.2	ANKYR	136..403	CDD:440430	81/266 (30%)
		ANK repeat	152..183	CDD:293786	7/30 (23%)
		ANK repeat	185..217	CDD:293786	9/31 (29%)
		ANK repeat	219..244	CDD:293786	12/24 (50%)
		ANK repeat	255..283	CDD:293786	5/27 (19%)
		ANK repeat	316..347	CDD:293786	12/30 (40%)
		ANK repeat	349..377	CDD:293786	11/27 (41%)
		ANK repeat	382..411	CDD:293786	8/28 (29%)
		Pat_PNPLA9	475..788	CDD:132851	161/322 (50%)