DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iPLA2-VIA and pla2g6

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_012816940.2	Gene:	pla2g6 / 780118	XenbaseID:	XB-GENE-920447	Length:	801	Species:	Xenopus tropicalis

Alignment Length:	888	Identity:	293/888 - (32%)
Similarity:	440/888 - (49%)	Gaps:	140/888 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KVVEIKSEALGTLQVLARDDAMLLFAPPFNSSNEKRAVYEIILQRPTSDSNTTSFSLYRSPVQQE 91
            ||.|:.....|....:..|..:||:      .|......:.:|..|.|..|  ::.|::...:.|
Frog    23 KVREVPLSEYGNCSCIQEDGRVLLY------RNRTAKSLDCVLVNPISPQN--AYRLFQLDSEHE 79

  Fly    92 AEERFNAFLQRLPVFVSIVKEYYNVNGLQKACDALADNPSWTLSHLIAYFNLVDYISNPKMLQCV 156
            |..||..:..:|..|....::...:..:|:..|.:..:|:|:|:|:.....|.:...:..:|:.:
Frog    80 ALLRFQEYAVKLRPFYESSRKGLRLETIQQLTDCIRSHPNWSLAHVAVDIGLRESFKHNGILRSL 144

  Fly   157 DQADAATLMSPFQLAIKQGHMEMVKALLP--LSKLEHLDINSNSVFHYAA-STTKEIINLIIDKS 218
            :..|.....:|..||.|:|.:|.::.|:.  .::.:..|.|..:|:|:|| .....:|.::....
Frog   145 NSTDCDGGSTPLHLACKKGDIECLQELVEECQARQDIADQNGETVYHHAAQQNNPRVIEILCSVP 209

  Fly   219 TVNLNHLNSDGYTPLHVACLADKPENVKALLLAGANVNLNAKD---IRKVYKTSAPTTVSSFLRT 280
            :|.:||.:::...||||||...|.|:|.|||...|..::..||   |....|.|......:.|..
Frog   210 SVGINHQSNNNEAPLHVACRMGKTESVLALLRCQARCDIIGKDGYPIHTAMKYSQNGCAEAILDV 274

  Fly   281 NVSKLYTQDMKYGGTPLHWCSSRETLHALIMEGCDVNATNFDGRTALHVMVARNRFECVVTLLAH 345
            :.::|:.:|.:|..||:||..:.|....||..||.||..:....|.||:||.|:|||..:.||.:
Frog   275 SANQLHAEDPRYQATPIHWAKNAEMARLLIQRGCKVNTRSKTSDTPLHIMVKRDRFEAAMVLLTN 339

  Fly   346 DAEIDVLDKDGNAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDEILY 410
            .|:.:...:.||..||:|::|..:.:::.|:|||.|:...|..|:||..:....:.||....:|.
Frog   340 GADPNAKGEHGNTPLHLAMKKDHLELIKALMVFGADVEQHNDFGETPGLIAARSSKGNNRKVLLS 404

  Fly   411 ILHSVGAKRCKDTGSKCPPGCNAKGNYNGIPPE--------APESVEQREHIE----HMLATTSR 463
            :|.:|||:||                   :||:        :|.||...:...    |.|.
Frog   405 MLCNVGAERC-------------------LPPDTQLLPTATSPSSVPPSDRSSGIGFHDLV---- 446

  Fly   464 QMMGGFLNAAANGILEKQQPAQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKENSSDSLA 528
                 :::.|.:|:|..|.      .||..::  |..:.|
Frog   447 -----YVSTALSGMLVPQD------TVDFRED--GLRVKD------------------------- 473

  Fly   529 SGSQKSAVSSPEQLPSPTSPIAAEIGDKPYGRGRLLCLDGGGIRGLVLVQMLLEIEKLSRTPIIH 593
                                             |||||||||||||||:|:|:.|||.:..||..
Frog   474 ---------------------------------RLLCLDGGGIRGLVLIQLLIAIEKAAGRPIRE 505

  Fly   594 MFDWIAGTSTGGILALALGCGKTMRQCMGLYLRMKEQCFVGSRPYNSEFFESILKDNLGEFNVMT 658
            :|||::|||||||||||:..|..|.....||.|||.:.|.|||||.|...|..||...||...|:
Frog   506 LFDWVSGTSTGGILALAIVHGMPMEYVRCLYFRMKNEVFHGSRPYESGPLEEFLKREFGENTKMS 570

  Fly   659 DIKHPKIMVTGVMADRKPVDLHLFRNYTSASDILGIVTPINNRRIPP----------PQPSEQLV 713
            |:::||::|||.::||.|.:|||||||          .|......||          ..|:||||
Frog   571 DVRNPKVIVTGTLSDRHPAELHLFRNY----------DPPETDHEPPYKSVASFRPVTAPAEQLV 625

  Fly   714 WRAARATGAAPSYFRAFGRFLDGGLIANNPTLDAMTEIHEYNMALRSAGRESEAIPVSVVMSLGT 778
            |||||::||||:|.|..||||||||::||||||||||:|:||..|:..|...:...:.:|:||||
Frog   626 WRAARSSGAAPTYLRPMGRFLDGGLLSNNPTLDAMTEMHQYNNCLKKKGMAGQVKKLGIVVSLGT 690

  Fly   779 GHIPVTELKDIDVFRPESIWDTAKLAYGISTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRF 843
            |..|...:..:|||||.:.|:..|...|...:|.::||..|.|||..|.||||||..|.:||||.
Frog   691 GKPPQISVSSVDVFRPSNPWEMMKTVVGARELGKMVVDCCTDSDGPAVSRARAWCEMIDVPYFRL 755

  Fly   844 NPQLSEDIAMDEKDDQKLINMLWHTKAYMHANRNKIIEMINFL 886
            :|||..|:.:||.:|..|:||||.|:.|::..|..:..:...|
Frog   756 SPQLQTDVMLDEVNDAVLVNMLWDTQIYIYQQREVLQRLAKIL 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786	17/62 (27%)
		Ank_2	168..258	CDD:289560	29/92 (32%)
		ANK	191..343	CDD:238125	52/155 (34%)
		ANK repeat	228..261	CDD:293786	13/32 (41%)
		ANK	291..412	CDD:238125	42/120 (35%)
		ANK repeat	292..320	CDD:293786	12/27 (44%)
		Ank_2	297..386	CDD:289560	32/88 (36%)
		ANK repeat	322..353	CDD:293786	12/30 (40%)
		ANK repeat	355..386	CDD:293786	11/30 (37%)
		ANK repeat	388..417	CDD:293786	8/28 (29%)
		Pat_PNPLA9	563..876	CDD:132851	161/322 (50%)
pla2g6	XP_012816940.2	ANK repeat	152..183	CDD:293786	7/30 (23%)
		Ank_2	156..248	CDD:403870	29/91 (32%)
		ANK repeat	185..217	CDD:293786	9/31 (29%)
		ANK repeat	219..244	CDD:293786	12/24 (50%)
		ANK repeat	255..283	CDD:293786	5/27 (19%)
		ANKYR	<286..406	CDD:223738	42/119 (35%)
		ANK repeat	316..347	CDD:293786	12/30 (40%)
		ANK repeat	349..377	CDD:293786	11/27 (41%)
		ANK repeat	382..411	CDD:293786	8/28 (29%)
		Pat_PNPLA9	475..788	CDD:132851	161/322 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2913
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2635
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2355
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D362279at33208
OrthoFinder	1	1.000	-	-		FOG0005157
OrthoInspector	1	1.000	-	-		oto105405
Panther	1	1.100	-	-	LDO	PTHR24139
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3123
SonicParanoid	1	1.000	-	-		X5526
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190