DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iPLA2-VIA and Tanc2

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_006534535.1	Gene:	Tanc2 / 77097	MGIID:	2444121	Length:	2079	Species:	Mus musculus

Alignment Length:	615	Identity:	130/615 - (21%)
Similarity:	221/615 - (35%)	Gaps:	149/615 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KSEALGTLQVLARDDAMLLFAPPF------NSSNEKRAVYEIILQRPTSDSNTTSFSLYRSPVQQ 90
            :.|.|....:..||...:...|.|      ....||..    .|..|.|.....:|...|...:.
Mouse   818 RMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTK----FLCDPRSGHTLLAFWFSRQEGKL 878

  Fly    91 EAEER------------FNAFLQRLPVFVSIVKEY---YNVNGLQKACDALAD--NPSWTLSHLI 138
            ..::.            |....:::.|..||::..   |:..||..|..:|.:  .|:..:|.|:
Mouse   879 NRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLL 943

  Fly   139 ----AYFNLVDYISNPKMLQCVD-------------------QADAATLMSPFQLAIKQGHMEMV 180
                |..|....:.|...:.||.                   .|.:.:.::|...|...|.:.:|
Mouse   944 ILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGFLSIV 1008

  Fly   181 KALL-PLSKLEHLDINSN-SVFHYAASTTKEIINLII---------DKSTVNLNH--------LN 226
            ..|. ..:|::|||.|.. ::.|.|.....|::..:|         .:.....:|        ..
Mouse  1009 VLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAA 1073

  Fly   227 SDGYTPLHVACLADKPENVKALLLAGANVNLNAKDIRKVYKTSAPTTVSSFLRTNVSKL------ 285
            |.|||.: |:.|.|.||..:..:   ....:|:.|  .::..:|.|..:...:.:|.:|
Mouse  1074 SMGYTEI-VSYLLDLPEKDEEEV---ERAQINSFD--SLWGETALTAAAGRGKLDVCRLLLEQGA 1132

  Fly   286 -YTQDMKYGGTPL-------HWCSSRETLHALIMEGCDVNATNFDGRTALHVMVARNRFECVVTL 342
             ..|..:.|..||       ||    :.:..|:..|.|||..:..|||.|.:..:......|..|
Mouse  1133 AVAQPNRRGAVPLFSTVRQGHW----QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFL 1193

  Fly   343 LAHDAEIDVLDKDGNAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDE 407
            ||..|.|.::||:|..||..|..|..:.:|:.||..|...:..:|:|:||..:    |:...|.|
Mouse  1194 LAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL----AAFYGDAE 1254

  Fly   408 ILYILHSVGAK----------------RCKDT---------GSKCPPGCNAKGNYNGIP--PEAP 445
            ::..|...||.                .|::|         |:|.  ||..      :|  |..|
Mouse  1255 VVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI--GCQT------LPSRPRGP 1311

  Fly   446 ES---VEQREHIEHMLATTSRQMMGGFLNAAANGILEKQQPAQKPVV----------VDTEKELK 497
            .:   ...:..|  |:...|:.|..|.:......:.|..|..|..:.          :.|.:|||
Mouse  1312 ATWAMATSKPDI--MIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELK 1374

  Fly   498 GQSIMDALLGMFTTKVNADEMKKENSSDSL 527
            ...:::  |.....|:|...|.:|.::.:|
Mouse  1375 VSLLLN--LSRCRRKMNDFGMAEEFATKAL 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786	15/78 (19%)
		Ank_2	168..258	CDD:289560	23/108 (21%)
		ANK	191..343	CDD:238125	40/183 (22%)
		ANK repeat	228..261	CDD:293786	9/32 (28%)
		ANK	291..412	CDD:238125	38/127 (30%)
		ANK repeat	292..320	CDD:293786	10/34 (29%)
		Ank_2	297..386	CDD:289560	29/95 (31%)
		ANK repeat	322..353	CDD:293786	10/30 (33%)
		ANK repeat	355..386	CDD:293786	9/30 (30%)
		ANK repeat	388..417	CDD:293786	7/28 (25%)
		Pat_PNPLA9	563..876	CDD:132851
Tanc2	XP_006534535.1	AAA_16	415..>500	CDD:379062
		PHA03095	930..>1224	CDD:222980	67/303 (22%)
		ANK repeat	963..989	CDD:293786	3/25 (12%)
		ANK repeat	991..1022	CDD:293786	7/30 (23%)
		ANK repeat	1108..1138	CDD:293786	5/29 (17%)
		ANK repeat	1140..1171	CDD:293786	10/34 (29%)
		ANKYR	<1170..1296	CDD:223738	33/129 (26%)
		ANK repeat	1174..1204	CDD:293786	10/29 (34%)
		ANK repeat	1206..1237	CDD:293786	9/30 (30%)
		ANK repeat	1239..1270	CDD:293786	9/34 (26%)
		ANK repeat	1272..1302	CDD:293786	5/31 (16%)
		TPR	<1324..1442	CDD:223533	17/81 (21%)
		TPR repeat	1331..1356	CDD:276809	5/24 (21%)
		TPR repeat	1361..1404	CDD:276809	10/44 (23%)
		TPR repeat	1409..1438	CDD:276809
		PHA03247	<1515..1745	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000