DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iPLA2-VIA and Pla2g6

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_036015396.1	Gene:	Pla2g6 / 53357	MGIID:	1859152	Length:	953	Species:	Mus musculus

Alignment Length:	1014	Identity:	302/1014 - (29%)
Similarity:	451/1014 - (44%)	Gaps:	257/1014 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LFAPPFN----------SSNEKRAVYEIILQRPTSD-----------SNTTSFSLYRSPVQQEAE 93
            ||:.||.          ||...|...::||.:..|:           :..:.|.|::...:.:|.
Mouse    17 LFSNPFRVKEVSLTDYVSSERVREEGQLILLQNVSNRTWDCVLVSPRNPQSGFRLFQLESEADAL 81

  Fly    94 ERFNAFLQRLPVFVSIVKEYYNVNGLQKACDALADNPSWTLSHLIAYFNLVDYISNPKMLQCVDQ 158
            ..|..|..:||.|.....:..:|..||...|.:.::||||::||.....:.:...:.:::.|.:.
Mouse    82 VNFQQFSSQLPPFYESSVQVLHVEVLQHLTDLIRNHPSWTVTHLAVELGIRECFHHSRIISCANS 146

  Fly   159 ADAATLMSPFQLAIKQGHMEMVKALLPLSKLEHLDINSN---SVFHYAA-STTKEIINLIIDKST 219
            .:.....:|..||.::|..|::..|:.....: :|:..|   :.||||. ....:::.|:...::
Mouse   147 TENEEGCTPLHLACRKGDSEILVELVQYCHAQ-MDVTDNKGETAFHYAVQGDNPQVLQLLGKNAS 210

  Fly   220 VNLNHLNSDGYTPLHVACLADKPENVKALLLAGANVNL---NAKDIRKVYKTSAPTTVSSFLRTN 281
            ..||.:|:.|.||||:||...|.|.|:.|||..|..|:   ....|....|.|........:..:
Mouse   211 AGLNQVNNQGLTPLHLACKMGKQEMVRVLLLCNARCNIMGPGGFPIHTAMKFSQKGCAEMIISMD 275

  Fly   282 VSKLYTQDMKYGGTPLHWCSSRETLHALIMEGCDVNATNFDGRTALHVMVARNRFECVVTLLAHD 346
            .::::::|.:||.:||||..:.|....|:..||||::|:..|.|||||.|.||||:||:.||.:.
Mouse   276 SNQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSSSGNTALHVAVMRNRFDCVMVLLTYG 340

  Fly   347 AEIDVLDKDGNAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDEILYI 411
            |......:.||..||:|:.|..:.:|:.|:|||.:::..|..|:||..:....:.......:|.:
Mouse   341 ANAGARGEHGNTPLHLAMSKDNMEMVKALIVFGAEVDTPNDFGETPALIASKISKLITRKALLTL 405

  Fly   412 LHSVGAKRCKDTGSKCPPGCNAKGNYNGIPPEAPESVEQREHIEHMLATTSRQMMGGFLNAAANG 476
            |.:|||.                                 .|...:...::.|.     :|||..
Mouse   406 LKTVGAD---------------------------------HHFPIIQGVSTEQG-----SAAATH 432

  Fly   477 ILEKQQPAQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKENSSDSLASGSQKSAVSSPEQ 541
            .|......|.|.:.....||  |.:|.                        .|.::|.|.
Mouse   433 PLFSLDRTQPPAISLNNLEL--QDLMP------------------------ISRARKPAF----- 466

  Fly   542 LPSPTSPIAAEIGDKPYGRGRLLCLDGGGIRGLVLVQMLLEIEKLSRTPIIHMFDWIAGTSTGGI 606
                   |.:.:.|:......||||||||::|||::|:|:.|||.|......:|||:||||||||
Mouse   467 -------ILSSMRDEKRSHDHLLCLDGGGVKGLVIIQLLIAIEKASGVATKDLFDWVAGTSTGGI 524

  Fly   607 LALALGCGKTMRQCMGLYLRMKEQCFVGSRPYNSEFFESILKDNLGEFNVMTDIKHPKIMVTGVM 671
            ||||:...|:|....|:|.|||::.|.|||||.|...|..||...||...|||:|.||:|:||.:
Mouse   525 LALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTL 589

  Fly   672 ADRKPVDLHLFRNYTSASDILGIVTPINNRRI---PPPQPSEQLVWRAARATGAAPSYFRAFGRF 733
            :||:|.:|||||||.:..   .:..|..|:.|   ||.||::||||||||::||||:|||..|||
Mouse   590 SDRQPAELHLFRNYDAPE---AVREPRCNQNINLKPPTQPADQLVWRAARSSGAAPTYFRPNGRF 651

  Fly   734 LDGGLIANNPTLDAMTEIHEYN------------------------------------------- 755
            |||||:||||||||||||||||
Mouse   652 LDGGLLANNPTLDAMTEIHEYNQDMIRKLPQGAAAGPGQDGTWVCSCCSCCSCCSCCSCCSCSCC 716

  Fly   756 ----------------------------------------------------------------- 755

Mouse   717 CCCSCCSCCSCCCCCSCCSCCSCCSCCSCCCCCSCCSCCCCCSCCSCCSCCSCCCSCCSCSCSCS 781

  Fly   756 --------------------------------------MALRSAGRESEAIPVSVVMSLGTGHIP 782
                                                  ::..|.|:.::...:|:|:|||||..|
Mouse   782 YSLSYSRSRVLSVPHSPLPSLGPVLTPIPTCGKSSLTTLSCSSQGQGNKVKKLSIVVSLGTGKSP 846

  Fly   783 VTELKDIDVFRPESIWDTAKLAYGISTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQL 847
            ...:..:|||||.:.|:.||..:|...:|.::||..|..|||.||||||||..:||.|||.||||
Mouse   847 QVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQL 911

  Fly   848 SEDIAMDEKDDQKLINMLWHTKAYMHANRNKIIEMINFL 886
            ..||.:||..|..|:|.||.|:.|::.:|.:..:::..|
Mouse   912 GSDIMLDEVSDAVLVNALWETEVYIYEHREEFQKLVQLL 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786	15/63 (24%)
		Ank_2	168..258	CDD:289560	30/96 (31%)
		ANK	191..343	CDD:238125	55/158 (35%)
		ANK repeat	228..261	CDD:293786	15/35 (43%)
		ANK	291..412	CDD:238125	45/120 (38%)
		ANK repeat	292..320	CDD:293786	12/27 (44%)
		Ank_2	297..386	CDD:289560	37/88 (42%)
		ANK repeat	322..353	CDD:293786	16/30 (53%)
		ANK repeat	355..386	CDD:293786	11/30 (37%)
		ANK repeat	388..417	CDD:293786	6/28 (21%)
		Pat_PNPLA9	563..876	CDD:132851	170/461 (37%)
Pla2g6	XP_036015396.1	Ank_2	103..183	CDD:423045	18/80 (23%)
		ANK repeat	119..149	CDD:293786	6/29 (21%)
		ANK repeat	151..183	CDD:293786	7/32 (22%)
		Ank_2	156..249	CDD:403870	30/93 (32%)
		ANK repeat	185..217	CDD:293786	7/31 (23%)
		ANK repeat	219..248	CDD:293786	14/28 (50%)
		PHA02875	220..>412	CDD:165206	67/191 (35%)
		ANK repeat	286..314	CDD:293786	12/27 (44%)
		ANK repeat	316..347	CDD:293786	16/30 (53%)
		ANK repeat	349..380	CDD:293786	11/30 (37%)
		Pat_PNPLA9	481..940	CDD:132851	170/461 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846748
Domainoid	1	1.000	217	1.000	Domainoid score	I2690
eggNOG	1	0.900	-	-		E1_COG3621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2635
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2055
Isobase	1	0.950	-	0	Normalized mean entropy	S4470
OMA	1	1.010	-	-		QHG49455
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005157
OrthoInspector	1	1.000	-	-		oto95219
orthoMCL	1	0.900	-	-		OOG6_104994
Panther	1	1.100	-	-	LDO	PTHR24139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3123
SonicParanoid	1	1.000	-	-		X5526
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740