Protein Alignment iPLA2-VIA and PNPLA8

DIOPT Version :9

• Sequence 1: NP_729565.2
• Gene: iPLA2-VIA / 39160
• FlyBaseID: FBgn0036053
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: XP_011514576.1
• Gene: PNPLA8 / 50640
• HGNCID: 28900
• Length: 810
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 134/554 - (24%)
• Similarity: 216/554 - (38%)
• Gaps: 179/554 - (32%)

  Fly   442 PEAPESVEQREHIEHMLATTSRQMMGGFLNAAANGIL-----------------------EKQQP 483
            |.:|.:      |..:|..:::|.:..||:....|:.                       |:::|
Human   297 PTSPSA------IPDVLQVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKYDSKSQSEEQEEP 355

  Fly   484 AQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKK--------------ENSSDSLASGSQKS 534
            |:....|..::                   ||:|.|:              :|.:.:|....:::
Human   356 AKTDQAVSKDR-------------------NAEEKKRLSLQREKIIARVSIDNRTRALVQALRRT 401

  Fly   535 --------------------------AVS-------------SPEQLPSPTSPIAAEIG--DKPY 558
                                      ||.             ..|.|.:....|.|.||  |...
Human   402 TDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILALIGYVDPVK 466

  Fly   559 GRG-RLLCLDGGGIRGLVLVQMLLEIEKLSRTPIIHMFDWIAGTSTGGILALALGC-GKTMRQCM 621
            ||| |:|.:||||.||:|.:|.|.::.:|::.|:..:||:|.|.|||.|||..||. ...:.:|.
Human   467 GRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYICGVSTGAILAFMLGLFHMPLDECE 531

  Fly   622 GLYLRMKEQCF-----VGSRP-------YNSEFFESILKDNLGEFNVMTDIKH---PKIMVTGVM 671
            .||.::....|     ||:..       |:|:.:|:||||.:|...::...::   ||:.....:
Human   532 ELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENILKDRMGSALMIETARNPTCPKVAAVSTI 596

  Fly   672 ADR--KPVDLHLFRNYTSASDILGIVTPINNRRIPPPQPSEQLVWRAARATGAAPSYFR--AFGR 732
            .:|  .| ...:||||       |....||:..:...|   ..:|:|.||:.|||.||.  |.|.
Human   597 VNRGITP-KAFVFRNY-------GHFPGINSHYLGGCQ---YKMWQAIRASSAAPGYFAEYALGN 650

  Fly   733 FL--DGGLIANNPTLDAMTEIHEYNMALRSAGRESEAIPVSVVMSLGTGH--------IPVTELK 787
            .|  ||||:.|||:..||   ||.......       :|:..::|||||.        :..|.||
Human   651 DLHQDGGLLLNNPSALAM---HECKCLWPD-------VPLECIVSLGTGRYESDVRNTVTYTSLK 705

  Fly   788 DIDVFRPESIWDTAKLAYGISTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQLSEDIA 852
            ........|..||.::        ::::|.....|                .||||||.:.|:|.
Human   706 TKLSNVINSATDTEEV--------HIMLDGLLPPD----------------TYFRFNPVMCENIP 746

  Fly   853 MDEKDDQKLINMLWHTKAYMHANRNKIIEMINFL 886
            :||..::||..:......|:..|..|:.::...|
Human   747 LDESRNEKLDQLQLEGLKYIERNEQKMKKVAKIL 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786
		Ank_2	168..258	CDD:289560
		ANK	191..343	CDD:238125
		ANK repeat	228..261	CDD:293786
		ANK	291..412	CDD:238125
		ANK repeat	292..320	CDD:293786
		Ank_2	297..386	CDD:289560
		ANK repeat	322..353	CDD:293786
		ANK repeat	355..386	CDD:293786
		ANK repeat	388..417	CDD:293786
		Pat_PNPLA9	563..876	CDD:132851	100/342 (29%)
PNPLA8	XP_011514576.1	Pat_PNPLA8	463..769	CDD:132850	105/350 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910