DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment iPLA2-VIA and nfkbiaa

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_998349.2	Gene:	nfkbiaa / 406463	ZFINID:	ZDB-GENE-040426-2227	Length:	310	Species:	Danio rerio

Alignment Length:	311	Identity:	71/311 - (22%)
Similarity:	115/311 - (36%)	Gaps:	73/311 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 HLIAYFNLVDY------ISNPKMLQCVDQADAAT-LMSPFQLAIKQGHMEMVKALL--------- 184
            |..|..|.||.      ..|.|..||.|:.|:.. .:...:...::...||.|..:
Zfish     4 HRAAMLNFVDCNVDEMDTKNRKTQQCEDRVDSGVDSLKEEEYETREISEEMEKLTIASLKETICE 68

  Fly   185 PLSKLEHLDINSNSVFHYAASTTKEIINLIIDKSTVN---LNHLNSDGYTPLHVACLADKPENVK 246
            |.:|:...|  .::..|.|.....|...:.|.|...|   ||..|:...|.||:|.:.::|:.|:
Zfish    69 PWAKVVTED--GDTYLHLAIIHEAEDYAVQIIKQCQNDPYLNRQNNQRQTALHLAVVTEQPQMVE 131

  Fly   247 ALLLAGANVNLNAKDIRKVYKTSAPTTVSSFLRTNVSKLYTQDMKYGGTPLHWCSSR-------- 303
            .||.||.:                |..|.               :.|.|.||....:
Zfish   132 RLLKAGCD----------------PQLVD---------------QSGNTALHLACKQGSLACFSV 165

  Fly   304 ----ETLHALIMEGCDVNATNFDGRTALHVMVARNRFECVVTLLAHDAEIDVLDK-DGNAALHIA 363
                :|.|...:    :...|:.|.|.||:....|....|.:|:...|::|..:: .|..:||:|
Zfish   166 LTQIQTQHLRSI----LTFPNYSGHTCLHIAAINNYLSMVESLVQLGADVDAKEQCSGRTSLHLA 226

  Fly   364 IEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDEILYILHS 414
            ::.:.:.:|..|:..|.|.|.....|.|..|:    ..|..:.||...|:|
Zfish   227 VDLQNLDLVHTLIALGADANSLTYGGYTAYHL----TFGRHNSEIQRQLYS 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786	14/71 (20%)
		Ank_2	168..258	CDD:289560	25/101 (25%)
		ANK	191..343	CDD:238125	35/166 (21%)
		ANK repeat	228..261	CDD:293786	10/32 (31%)
		ANK	291..412	CDD:238125	31/133 (23%)
		ANK repeat	292..320	CDD:293786	6/39 (15%)
		Ank_2	297..386	CDD:289560	23/101 (23%)
		ANK repeat	322..353	CDD:293786	9/30 (30%)
		ANK repeat	355..386	CDD:293786	9/30 (30%)
		ANK repeat	388..417	CDD:293786	8/27 (30%)
		Pat_PNPLA9	563..876	CDD:132851
nfkbiaa	NP_998349.2	ANK repeat	77..111	CDD:293786	9/35 (26%)
		Ank_4	78..134	CDD:290365	15/55 (27%)
		ANK	108..239	CDD:238125	35/165 (21%)
		ANK repeat	115..144	CDD:293786	11/44 (25%)
		Ank_2	118..214	CDD:289560	27/130 (21%)
		ANK repeat	146..182	CDD:293786	6/39 (15%)
		ANK repeat	184..214	CDD:293786	9/29 (31%)
		Ank_5	204..258	CDD:290568	14/53 (26%)
		ANK repeat	218..246	CDD:293786	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591956
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930