DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iPLA2-VIA and pla2g6

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_021324984.1	Gene:	pla2g6 / 406370	ZFINID:	ZDB-GENE-040426-2079	Length:	824	Species:	Danio rerio

Alignment Length:	905	Identity:	304/905 - (33%)
Similarity:	450/905 - (49%)	Gaps:	155/905 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LGTLQVLAR-----DDAMLLFAPPFN-----------------------SSNEKRAVYEIILQRP 72
            |.|:|.|.|     .....||:.|:.                       ..|::...::.:|..|
Zfish     4 LVTMQFLGRILDTVSSVSSLFSNPYRVRDVQLSDYNGKILHQQEGRLALYRNQQSQSWDCLLLCP 68

  Fly    73 TSDSNTTSFSLYRSPVQQEAEERFNAFLQRLPVFVSIVKEYYNVNGLQKACDALADNPSWTLSHL 137
            .|.|  .:..:::...:::|...|..:..:|..|..:::.......||...|.:.::|.|:.:|:
Zfish    69 ESPS--VALRMFQVASEEDAMNWFPQYALKLRPFYEMLRPPLKPEMLQPIVDCVRNHPDWSSAHI 131

  Fly   138 IAYFNLVDYISNPKMLQCVDQADAATLMSPFQLAIKQGHMEMVKALLP--LSKLEHLDINSNSVF 200
            .....|.|.:.:..:|..::..||.. .:|..||.::|.:..|:.||.  .::.:..|.|..:..
Zfish   132 AVDTGLRDCLKHNYILSQMNSRDAQG-QTPLHLACERGDVGCVRELLEECQARTDVKDKNGETPM 195

  Fly   201 HYAASTTKE-IINLIIDKSTVNLNHLNSDGYTPLHVACLADKPENVKALLLAGANVNL---NAKD 261
            |.||..... ||.::..:....:|.||:.|.||:|:||...:.|.||.||..||..::   |...
Zfish   196 HCAAKQDSALIIEVLCAQLCAGVNELNAAGETPMHIACRLGRVEVVKGLLGGGARCDIMGNNGFP 260

  Fly   262 IRKVYKTSAPTTVSSFLRTNVSKLYTQDMKYGGTPLHWCSSRETLHALIMEGCDVNATNFDGRTA 326
            |....|.|..:...:.|.::.::|..:|..||||||||..:.|....|:..||:||..:..|.:.
Zfish   261 IHTAMKFSEKSCAEAILSSSPNQLLAEDPVYGGTPLHWAKTAEMSRLLLDRGCNVNYLSKTGESP 325

  Fly   327 LHVMVARNRFECVVTLLAHDAEIDVLDKDGNAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKT 391
            ||::..|.|||..:|||.|.|:.::..:|||.|||:|::...:.:::.|:|||.|:.:.|..|:|
Zfish   326 LHILTKRGRFEAAMTLLTHGADANIRGQDGNTALHLAMKLDNMDLIKALMVFGADVEVHNDVGET 390

  Fly   392 PRHMVGNDASGNKDDEILYILHSVGAKRCKDTGSKCPPGCNAKGNYNGIPPEAPESVEQREHIEH 456
            |..:....:.|:....:|.:|.|||.:||.      ||..|:.  .:.:....|..:...:.::.
Zfish   391 PGLIAARTSKGSNRKVLLNMLCSVGVERCH------PPSLNSP--THSLRKAPPPGIGFDDIMQV 447

  Fly   457 MLATTSRQMMGGFLNAAANGILEKQQPAQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKE 521
            .:|.|:  |..||                                           |.||.:|..
Zfish   448 AVAVTA--MSRGF-------------------------------------------VEADGLKTG 467

  Fly   522 NSSDSLASGSQKSAVSSPEQLPSPTSPIAAEIGDKPYGRGRLLCLDGGGIRGLVLVQMLLEIEKL 586
            |..|                                    ||||||||||:||||:|:|:.:||.
Zfish   468 NKMD------------------------------------RLLCLDGGGIKGLVLIQLLIALEKE 496

  Fly   587 SRTPIIHMFDWIAGTSTGGILALALGCGKTMRQCMGLYLRMKEQCFVGSRPYNSEFFESILKDNL 651
            :..||..:|||::|||||||||||:..||:|.....||.|||||.|.|||||.|...|..||:..
Zfish   497 AGRPIRELFDWVSGTSTGGILALAIVHGKSMEYLRCLYFRMKEQVFKGSRPYESGPLEEFLKNEF 561

  Fly   652 GEFNVMTDIKHPKIMVTGVMADRKPVDLHLFRNYTSAS-------------------------DI 691
            ||...|||:.||::|||.|:|||.|.:|||||||...:                         |:
Zfish   562 GENTKMTDVTHPRVMVTSVLADRHPGELHLFRNYDPPALQRDPPYKSTATFQPLTVPQGWEDEDL 626

  Fly   692 L--GIVTPINNRRIPPPQPSEQLVWRAARATGAAPSYFRAFGRFLDGGLIANNPTLDAMTEIHEY 754
            |  |...|...||  .....|||||||||::||||:|||..||||||||:|||||||||||||::
Zfish   627 LLVGYTRPPRKRR--KVTDEEQLVWRAARSSGAAPTYFRPMGRFLDGGLLANNPTLDAMTEIHQF 689

  Fly   755 NMALRSAGRESEAIPVSVVMSLGTGHIPVTELKDIDVFRPESIWDTAKLAYGISTIGNLLVDQAT 819
            |.||::.||:.:...:.||:|||||..|...:..:|||||.:..:.||...|:..:|.:|||..|
Zfish   690 NKALKAQGRDEDVTRLGVVVSLGTGKPPQVAVNSVDVFRPSNPIELAKTFVGVKELGKMLVDCCT 754

  Fly   820 CSDGRVVDRARAWCSTIGIPYFRFNPQLSEDIAMDEKDDQKLINMLWHTKAYMHANRNKI 879
            .|||..||||||||....|.|.|.:||||:::.:||..|..|::|||.|:.|::.:|:.|
Zfish   755 DSDGCAVDRARAWCEMADINYHRLSPQLSQEVMLDEVSDAVLVDMLWETQMYLYEHRDVI 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786	15/62 (24%)
		Ank_2	168..258	CDD:289560	29/95 (31%)
		ANK	191..343	CDD:238125	52/155 (34%)
		ANK repeat	228..261	CDD:293786	14/35 (40%)
		ANK	291..412	CDD:238125	44/120 (37%)
		ANK repeat	292..320	CDD:293786	14/27 (52%)
		Ank_2	297..386	CDD:289560	33/88 (38%)
		ANK repeat	322..353	CDD:293786	12/30 (40%)
		ANK repeat	355..386	CDD:293786	12/30 (40%)
		ANK repeat	388..417	CDD:293786	8/28 (29%)
		Pat_PNPLA9	563..876	CDD:132851	171/339 (50%)
pla2g6	XP_021324984.1	ANK	<120..177	CDD:238125	13/57 (23%)
		ANK repeat	124..154	CDD:293786	6/29 (21%)
		ANK	151..277	CDD:238125	36/126 (29%)
		ANK repeat	157..188	CDD:293786	7/31 (23%)
		ANK repeat	190..222	CDD:293786	7/31 (23%)
		ANK repeat	224..249	CDD:293786	11/24 (46%)
		ANK	291..408	CDD:238125	43/116 (37%)
		ANK repeat	291..319	CDD:293786	14/27 (52%)
		ANK repeat	321..352	CDD:293786	12/30 (40%)
		ANK repeat	354..385	CDD:293786	12/30 (40%)
		ANK repeat	387..415	CDD:293786	7/27 (26%)
		Pat_PNPLA9	473..811	CDD:132851	171/339 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591952
Domainoid	1	1.000	206	1.000	Domainoid score	I2853
eggNOG	1	0.900	-	-		E1_COG3621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2635
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1264
OMA	1	1.010	-	-		QHG49455
OrthoDB	1	1.010	-	-		D362279at33208
OrthoFinder	1	1.000	-	-		FOG0005157
OrthoInspector	1	1.000	-	-		oto41583
orthoMCL	1	0.900	-	-		OOG6_104994
Panther	1	1.100	-	-	LDO	PTHR24139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3123
SonicParanoid	1	1.000	-	-		X5526
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800