DRSC/TRiP Functional Genomics Resources

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Protein Alignment iPLA2-VIA and Pnpla8

DIOPT Version :10

Sequence 1:NP_729565.2 Gene:iPLA2-VIA / 39160 FlyBaseID:FBgn0036053 Length:887 Species:Drosophila melanogaster
Sequence 2:NP_001101490.2 Gene:Pnpla8 / 314075 RGDID:1311444 Length:776 Species:Rattus norvegicus


Alignment Length:554 Identity:133/554 - (24%)
Similarity:215/554 - (38%) Gaps:165/554 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   438 NGIPPEAPESVEQREHIEHMLATTSRQMMGGFLNAAANGIL-----------------------E 479
            :|.|....:.:.....:...|..:::|.:..||:....|:.                       |
  Rat   253 SGPPLNVEDKLSSSTQLPEALPVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKSDPKSQPEE 317

  Fly   480 KQQPAQ--KPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKENSSDSLASGSQKS-------- 534
            :::|::  :|:..|.:.|.|.:.::.      ..|:.| .:..:|.:.:|....:::        
  Rat   318 EEEPSKTDEPICKDKKAEEKKRVLLQ------REKIIA-RVSIDNRTRALVQALRRTTDPKLCIT 375

  Fly   535 ------------------AVS-------------SPEQLPSPTSPIAAEIG--DKPYGRG-RLLC 565
                              ||.             ..|.|.:....|.|.||  |...||| |:|.
  Rat   376 RVEELTFHLLEFPEGKGVAVKEKIIPYLLRLRQIKDETLQAAVREILALIGYVDPVKGRGIRILA 440

  Fly   566 LDGGGIRGLVLVQMLLEIEKLSRTPIIHMFDWIAGTSTGGILALALGC-GKTMRQCMGLYLRMKE 629
            :||||.||:|.:|.|.::.:|::.||..:||:|.|.|||.|||..||. ...:.:|..||.::..
  Rat   441 IDGGGTRGVVALQTLRKLVELTQKPIHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGS 505

  Fly   630 QCF-----VGSRP-------YNSEFFESILKDNLGE---FNVMTDIKHPKIMVTGVMADR-KPVD 678
            ..|     ||:..       |:|..:|.||||.:|.   .....|...||:.....:.:| :...
  Rat   506 DVFTQNVIVGTVKMSWSHAFYDSHTWEKILKDKVGSALMIETARDPLCPKVAAVSTIVNRGQTPK 570

  Fly   679 LHLFRNY----TSASDILGIVTPINNRRIPPPQPSEQLVWRAARATGAAPSYFR--AFGRFL--D 735
            ..:||||    .:.|..||              ..:..:|:|.||:.|||.||.  |.|..|  |
  Rat   571 AFVFRNYGHFPGTNSHYLG--------------GCQYKMWQAIRASSAAPGYFAEYALGNDLHQD 621

  Fly   736 GGLIANNPTLDAMTEIHEYNMALRSAGRESEAIPVSVVMSLGTGH--------IPVTELKDIDVF 792
            |||:.|||:..|   :||........       |:..::|||||.        ...|.||     
  Rat   622 GGLLLNNPSALA---LHECKCIWPDT-------PLECIVSLGTGRYESDVRNTTTYTSLK----- 671

  Fly   793 RPESIWDTAKLAYGISTIG-----NLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQLSEDIA 852
                    .||:..||:..     ::::|....:|                .||||||.:.|:|.
  Rat   672 --------TKLSNVISSATDTEEVHIMLDGLLPAD----------------TYFRFNPVICENIP 712

  Fly   853 MDEKDDQKLINMLWHTKAYMHANRNKIIEMINFL 886
            :||..::||..:......|:..|..|:.::...|
  Rat   713 LDESRNEKLDQLQLEGMKYLERNDEKMKKLAKIL 746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
iPLA2-VIANP_729565.2 ANKYR 143..418 CDD:440430
ANK repeat 166..226 CDD:293786
ANK repeat 228..261 CDD:293786
ANK repeat 292..320 CDD:293786
ANK repeat 322..353 CDD:293786
ANK repeat 355..386 CDD:293786
ANK repeat 388..417 CDD:293786
Pat_PNPLA9 563..876 CDD:132851 100/350 (29%)
Pnpla8NP_001101490.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..274 2/20 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 306..331 3/24 (13%)
Pat_PNPLA8 429..735 CDD:132850 105/358 (29%)
GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 443..448 3/4 (75%)
GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 475..479 2/3 (67%)
DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 621..623 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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