DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment iPLA2-VIA and TANC2

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_011522899.1	Gene:	TANC2 / 26115	HGNCID:	30212	Length:	2075	Species:	Homo sapiens

Alignment Length:	685	Identity:	141/685 - (20%)
Similarity:	233/685 - (34%)	Gaps:	198/685 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KSEALGTLQVLARDDAMLLFAPPF------NSSNEKRAVYEIILQRPTSDSNTTSFSLYRSPVQQ 90
            :.|.|....:..||...:...|.|      ....||..    .|..|.|.....:|...|...:.
Human   818 RMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTK----FLCDPRSGHTLLAFWFSRQEGKL 878

  Fly    91 EAEER------------FNAFLQRLPVFVSIVKEY---YNVNGLQKACDALAD--NPSWTLSHLI 138
            ..::.            |....:::.|..||::..   |:..||..|..:|.:  .|:..:|.|:
Human   879 NRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLL 943

  Fly   139 ----AYFNLVDYISNPKMLQCVD-------------------QADAATLMSPFQLAIKQGHMEMV 180
                |..|....:.|...:.||.                   .|.:.:.::|...|...|::.:|
Human   944 ILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIV 1008

  Fly   181 KALL-PLSKLEHLDINSN-SVFHYAASTTKEIINLII---------DKSTVNLNH--------LN 226
            ..|. ..:|::|||.|.. ::.|.|.....|::..:|         .:.....:|        ..
Human  1009 VLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAA 1073

  Fly   227 SDGYTPLHVACLADKPENVKALLLAGANVNLNAKDIRKVYKTSAPTTVSSFLRTNVSKL------ 285
            |.|||.: |:.|.|.||..:..:   ....:|:.|  .::..:|.|..:...:..|.:|
Human  1074 SMGYTEI-VSYLLDLPEKDEEEV---ERAQINSFD--SLWGETALTAAAGRGKLEVCRLLLEQGA 1132

  Fly   286 -YTQDMKYGGTPL-------HWCSSRETLHALIMEGCDVNATNFDGRTALHVMVARNRFECVVTL 342
             ..|..:.|..||       ||    :.:..|:..|.|||..:..|||.|.:..:......|..|
Human  1133 AVAQPNRRGAVPLFSTVRQGHW----QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFL 1193

  Fly   343 LAHDAEIDVLDKDGNAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDE 407
            ||..|.|.::||:|..||..|..|..:.:|:.||..|...:..:|:|:||..:    |:...|.|
Human  1194 LAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL----AAFYGDAE 1254

  Fly   408 ILYILHSVGAK----------------RCKDT---------GSKCPPGCNAKGNYNGIP--PEAP 445
            ::..|...||.                .|::|         |:|.  ||..      :|  |..|
Human  1255 VVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI--GCQT------LPSRPRGP 1311

  Fly   446 ES---VEQREHIEHMLATTSRQMMGGFLNAAANGILEKQQPAQKPVV----------VDTEKELK 497
            .:   ...:..|  |:...|:.|..|.:......:.|..|..|..:.          :.|.:|||
Human  1312 ATWAMATSKPDI--MIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELK 1374

  Fly   498 GQSIMDAL--------LGM---FTTKVNADEMK-------------KENSSDSLASG-------- 530
            ...:::..        .||   |.||  |.|:|             |.:||...|:.
Human  1375 VSLLLNLSRCRRKMNDFGMAEEFATK--ALELKPKSYEAYYARARAKRSSSRQFAAALEDLNEAI 1437

  Fly   531 -----------------SQKSAVSSPEQLPSPTSP 548
                             .:...:..|:|.|.|..|
Human  1438 KLCPNNREIQRLLLRVEEECRQMQQPQQPPPPPQP 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786	15/78 (19%)
		Ank_2	168..258	CDD:289560	23/108 (21%)
		ANK	191..343	CDD:238125	40/183 (22%)
		ANK repeat	228..261	CDD:293786	9/32 (28%)
		ANK	291..412	CDD:238125	38/127 (30%)
		ANK repeat	292..320	CDD:293786	10/34 (29%)
		Ank_2	297..386	CDD:289560	29/95 (31%)
		ANK repeat	322..353	CDD:293786	10/30 (33%)
		ANK repeat	355..386	CDD:293786	9/30 (30%)
		ANK repeat	388..417	CDD:293786	7/28 (25%)
		Pat_PNPLA9	563..876	CDD:132851
TANC2	XP_011522899.1	AAA_16	415..>457	CDD:289934
		Ank_4	962..1011	CDD:290365	7/48 (15%)
		ANK repeat	963..989	CDD:293786	3/25 (12%)
		ANK	986..1194	CDD:238125	47/217 (22%)
		ANK repeat	991..1022	CDD:293786	7/30 (23%)
		Ank_2	996..1132	CDD:289560	29/141 (21%)
		ANK repeat	1108..1138	CDD:293786	5/29 (17%)
		Ank_2	1112..1204	CDD:289560	24/95 (25%)
		ANK repeat	1140..1171	CDD:293786	10/34 (29%)
		ANK	1168..1293	CDD:238125	34/128 (27%)
		ANK repeat	1174..1204	CDD:293786	10/29 (34%)
		Ank_2	1178..1270	CDD:289560	28/95 (29%)
		ANK repeat	1206..1237	CDD:293786	9/30 (30%)
		ANK repeat	1239..1270	CDD:293786	9/34 (26%)
		ANK repeat	1272..1302	CDD:293786	5/31 (16%)
		TPR_11	1331..1406	CDD:290150	16/76 (21%)
		TPR repeat	1331..1356	CDD:276809	5/24 (21%)
		TPR repeat	1361..1404	CDD:276809	10/44 (23%)
		TPR_11	1377..1441	CDD:290150	12/65 (18%)
		TPR repeat	1409..1438	CDD:276809	4/28 (14%)
		TFIIA	1487..>1714	CDD:281188
		ANAPC1	<1512..1583	CDD:289618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000