DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iPLA2-VIA and ipla-5

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_501497.2	Gene:	ipla-5 / 186763	WormBaseID:	WBGene00019229	Length:	497	Species:	Caenorhabditis elegans

Alignment Length:	639	Identity:	152/639 - (23%)
Similarity:	246/639 - (38%)	Gaps:	209/639 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 RTNVSKLYTQDMKYGGTPLHWCSSRETLHALIMEGCDVNATNFDGRTALHVMVARNRFECVVTLL 343
            |.|..::|.:.:             :..||:..:       |.||..|..|   ||.
Worm     8 RINAQEIYKRHI-------------DIFHAITYD-------NIDGLVAAFV---RNE-------- 41

  Fly   344 AHDAEIDVLDKDGNAALHIA--IEKKLVPIVQCLVVFGCDI-NLKNKDGKTPRHMVGNDASGNKD 405
                ..|:.||:||..||:|  :.::|:....|:...|.|: |.||.|||||..|. :||:..:|
Worm    42 ----PFDIKDKNGNTPLHLAAKLNRRLLCRAVCVYAAGLDLWNSKNNDGKTPIEMT-DDANIKRD 101

  Fly   406 DEILYILHSVGAKRCKDTGSKCPPGCNAKGNYNGIPPEAPESVEQREHIEHMLATTSRQMMGGFL 470
                  |.|:...|                          .||:.    .||
Worm   102 ------LQSISTSR--------------------------SSVDS----HHM------------- 117

  Fly   471 NAAANGILEKQQPAQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKENSSDSLASGSQKSA 535
              |.|.:|             .||                 |:|.:|.:.:|         ||.
Worm   118 --AYNKLL-------------IEK-----------------KINENEEQNQN---------QKV- 140

  Fly   536 VSSPEQLPSPTSPIAAEIGDKPYGRGRLLCLDGGGIRGLVLVQMLLEIEKLSRTPIIHMFDWIAG 600
                                       :|.|||||:|.::...:||.:|:....|:.:...||||
Worm   141 ---------------------------ILSLDGGGLRVVLQCAILLAVERELGEPLRNRIHWIAG 178

  Fly   601 TSTGGILALALGCGKTMRQCMGLYLRMKEQCFVGSRPYNSEF-------FESILKDNLGEFNVMT 658
            ||.|||:|.::|.|..:...:.||:.::::.|.|:   |.:|       .|:.|::.:|...:|:
Worm   179 TSCGGIMASSIGVGIDLADALRLYIIIRKRIFGGN---NQKFPKHSALGIETCLQEVMGSKTLMS 240

  Fly   659 DIKHPKIMVTGVMADRKPVDLHLFRNYTSASDI-----LGIVTPINNRRIPPPQPSEQLVWRAAR 718
            .....:::||.......|..|.|||:|....|.     ||..           .|::.|:|:|.|
Worm   241 KCTAHRLVVTTAKVTLAPPQLVLFRSYAPRIDSKEFEQLGYF-----------NPNKILLWKAIR 294

  Fly   719 ATGAAPSYFRAFGRFLDGGLIANNPTLDAMTEIHEYNMALRSAGRESEAIPVSVVMSLGTGHIPV 783
            .|.|||:||.:|....||.|..|||.:..|||..:........|: :....:..|:|:|||..|.
Worm   295 CTTAAPTYFPSFNGMADGALFCNNPCIMVMTEFAKLKKIENYRGK-NNTDEIGCVISVGTGIEPS 358

  Fly   784 TELKDIDVFRPESIWDTAKLAYGISTI-GN-------------LLVDQATCSDGRVVDRARAWCS 834
            ..:..||:          .|..|::.| ||             :.:.|.|.|....|.::|.||.
Worm   359 YPINGIDI----------NLTSGLTGITGNWREIIENTKNLITVFLYQCTSSHNVHVGQSREWCH 413

  Fly   835 TIGIPYFRFNPQLSEDIAMDEKDDQKLINMLWHTKAYMHAN-RNKIIEMINFLK 887
            ::.:|:|||:|.|:....:|....:.:.|.::..:.|:... :..|.::...||
Worm   414 SMQVPFFRFSPHLAAPFELDNCKIEDITNAMFDNEVYIRTEIKQHISDLCRLLK 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786
		Ank_2	168..258	CDD:289560
		ANK	191..343	CDD:238125	12/63 (19%)
		ANK repeat	228..261	CDD:293786
		ANK	291..412	CDD:238125	33/123 (27%)
		ANK repeat	292..320	CDD:293786	2/27 (7%)
		Ank_2	297..386	CDD:289560	22/91 (24%)
		ANK repeat	322..353	CDD:293786	7/30 (23%)
		ANK repeat	355..386	CDD:293786	10/33 (30%)
		ANK repeat	388..417	CDD:293786	11/28 (39%)
		Pat_PNPLA9	563..876	CDD:132851	95/339 (28%)
ipla-5	NP_501497.2	ANK	21..>90	CDD:238125	28/90 (31%)
		Ank_5	44..92	CDD:290568	20/47 (43%)
		ANK repeat	49..83	CDD:293786	10/33 (30%)
		Pat_PNPLA9	141..455	CDD:132851	95/338 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4470
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104994
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.620