DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iPLA2-VIA and C45B2.6

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001370408.1	Gene:	C45B2.6 / 180874	WormBaseID:	WBGene00016661	Length:	762	Species:	Caenorhabditis elegans

Alignment Length:	951	Identity:	214/951 - (22%)
Similarity:	368/951 - (38%)	Gaps:	282/951 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VDQPANKVVEIKSEALGTLQVLARDDAMLLFAPPFNSSNEKRAVYEIILQRPTSDSNTT---SFS 82
            |:....:..:.:.:|.|:....:...|..::..|.    :|...:.|..:..|:.|..|   .::
Worm    10 VEDKIKEYADAQHKAAGSTSQASNPQAQSMWPGPV----DKTLKFSINSKLSTNFSQATYGDGYA 70

  Fly    83 LYRSPVQQEAEERFNAFLQRLPVFVSIVKEYYNVNG--------LQKACDALADNPSWTLSHLIA 139
            |..:|         |.::           .|:|.|.        |.|..|.       :::||..
Worm    71 LVYTP---------NNYV-----------VYFNKNASYIDDLEYLWKEFDE-------SITHLNN 108

  Fly   140 YFNLVDYISNPKMLQCVDQADAATLMSPFQLAIKQGHMEMVKAL-------LPLSKLEHLDINSN 197
            ..|:::.:. |.||:   :.:..:..|....||..|....||..       ..:|||..   ..:
Worm   109 PINVINDLV-PVMLR---EKELQSECSAVYFAIFSGFSNYVKEEKKKEGDGFSMSKLNR---RGD 166

  Fly   198 SVFHYAAS-TTKEIINLIIDK--STVNLNHLNSDGYTPLHVACLADKPENV-------------K 246
            :..|.||. .:..::.::.||  ..:.:||   :|.|.|.||  ..:||.|             |
Worm   167 TPVHVAARFASLSLLQMVWDKYFDPLTMNH---NGQTILQVA--RHRPEIVKYINSHVTGEVCDK 226

  Fly   247 ALLLAGANVNLNAKD----IRKVYKTS----------APTTV---SSF----LRTNVSKLYTQDM 290
            .::.|..:......|    ..|:.:.|          :|..|   |||    |.:.:..||.||.
Worm   227 MIITAETHPKPETPDYPRSFEKILEYSIKNNLPHCLLSPADVLNKSSFSLRDLESVLRILYVQDS 291

  Fly   291 KYGGTPLHWCSSRETLHA----------LIMEGCD---VNATNFDGRTALHVMVARNRFECVVTL 342
            .:.|..|   :|:...|.          |::....   :||.:.:|.|.:|.:........::.|
Worm   292 DFLGRLL---NSKNVFHTFDNFVKDHQKLMLSFAKAEMINAQDLNGLTPMHYIAKNGNLSTIILL 353

  Fly   343 LAHDAEIDVLDKDGNAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDE 407
            .:|.|.:::||..|.:.:..|:|:..|.||:..:.|                      .|:..|.
Worm   354 WSHGANVNMLDNKGMSPMDYALERDDVDIVKAFLAF----------------------DGHSTDR 396

  Fly   408 ILYILHSVGAKRCKDTGSKCPPGCNAKGNYNGIPPEAPESVEQREHIEHMLATTSRQMMGGFLNA 472
            ||        |...::..||..
Worm   397 IL--------KAALNSRRKCAE------------------------------------------- 410

  Fly   473 AANGILEKQQPAQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKENSSDSLASGSQKSAVS 537
                :|:|...|                              .:|.|::|...:|.:.|.:...:
Worm   411 ----VLQKHFKA------------------------------LEEGKEKNIKYNLENPSHRRCQN 441

  Fly   538 SPEQLPSPTSPIAAEIGDKPYGRGRLLCLDGGGIRGLVLVQMLLEIEKLSRTPIIHMFDWIAGTS 602
            .|        |:..:       ...:|.:||||::|::.:|:|.||||:.....:..|:.|.|||
Worm   442 FP--------PLTKK-------DSVILSIDGGGMKGILALQLLKEIEKVVGNKFLRWFNHIGGTS 491

  Fly   603 TGGILALAL----GCGKTMRQCMGLYLRMKEQCFVGSRPYNSEFFESIL-----KDNLGEFNVMT 658
            ||.::.|.|    .....:||    |.|||:..|:|||||:.|..|:.|     :|.|.:.....
Worm   492 TGSMITLGLVKYGNIDHVIRQ----YFRMKDDIFIGSRPYSGEGLENALLNEFGRDTLQQLGEKN 552

  Fly   659 DIKHPKIMVTGVMADRKPVDLHLFRNYTSASDILGIVTPINNRRIPP-PQPSEQLVWRAA---RA 719
            .|   :|.:.....|..|..|::||:|              |.|.|. .|...:.||.||   ||
Worm   553 GI---RISIPVARVDISPPLLYMFRSY--------------NIRDPSFDQAGMKPVWAAAKVVRA 600

  Fly   720 TGAAPSYFRAF-GRFLDGGLIANNPTLDAMTEIH--EYNMALRSAGRESEAIPVSVVMSLGTGHI 781
            :.||||:|... |:|:|||||||||.:|.:|:..  ||....|:..:        :::|:|||.:
Worm   601 SSAAPSFFPPVDGKFMDGGLIANNPAVDILTDCQRLEYERNERNVSK--------IMVSIGTGSM 657

  Fly   782 PVTELKDIDVFRPESIWDTAKLAYGISTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQ 846
            . .:::::|:.:|.::.........|..:.::.::|.|.:||..|:|||.....:|:.:|||.|.
Worm   658 Q-KKIENVDLMKPTTMGGIVNTFNQILHLKDVFIEQLTAADGVTVERARWMAEAMGMAFFRFTPN 721

  Fly   847 LSEDIAMDEKDDQKLINMLWHTKAYMHANRNKIIEMINFLK 887
            |...:|:|||||..|::.:...|....|.||::..:.:.||
Worm   722 LEFPVAIDEKDDSALLDAMLAVKYEAVAMRNEMYMLSSILK 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786	16/69 (23%)
		Ank_2	168..258	CDD:289560	25/112 (22%)
		ANK	191..343	CDD:238125	40/201 (20%)
		ANK repeat	228..261	CDD:293786	10/45 (22%)
		ANK	291..412	CDD:238125	26/133 (20%)
		ANK repeat	292..320	CDD:293786	7/40 (18%)
		Ank_2	297..386	CDD:289560	21/101 (21%)
		ANK repeat	322..353	CDD:293786	6/30 (20%)
		ANK repeat	355..386	CDD:293786	7/30 (23%)
		ANK repeat	388..417	CDD:293786	4/28 (14%)
		Pat_PNPLA9	563..876	CDD:132851	107/328 (33%)
C45B2.6	NP_001370408.1	Ank_2	<327..387	CDD:403870	16/59 (27%)
		ANK repeat	333..364	CDD:293786	6/30 (20%)
		Patatin_and_cPLA2	452..740	CDD:416256	105/317 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4470
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.860