DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iPLA2-VIA and ipla-3

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001367163.1	Gene:	ipla-3 / 180354	WormBaseID:	WBGene00012319	Length:	1047	Species:	Caenorhabditis elegans

Alignment Length:	932	Identity:	249/932 - (26%)
Similarity:	401/932 - (43%)	Gaps:	190/932 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DQPANKVVEIKSEALGTLQVLARDDAMLLFAPPFNSSNEKRAVYEIILQRPTSDSNTTSFSLYRS 86
            |..|.:..|:|::.|..|.:..           :|.:|||..:                 ||:||
Worm   226 DLRAKEEEELKNKPLYHLAITL-----------YNENNEKYVM-----------------SLFRS 262

  Fly    87 PVQ----------QEAEERFNAFLQRLPVFVSIVKEYYNVNGLQKACDALADNPSWTLSHLIAYF 141
            ...          :|..|.|..|    |..|:| |:|     |......|.||.:|...|:.:..
Worm   263 HKLADVVALCERCRENPELFRVF----PKNVNI-KDY-----LHTIFHELRDNMTWKSVHISSKI 317

  Fly   142 NLVDYISN------PKMLQCVDQADAATLMSPFQLAIKQGHMEMVKALLPLSKLEH-LDIN---- 195
            .|::|..|      .|.|..:.|.:.   :||..:|::...:|.|..:     |:| .|||
Worm   318 GLLEYFENMKEHKLKKYLNLIVQPEG---LSPLMIAVQNTQIETVSWM-----LDHGADINILSS 374

  Fly   196 -SNSVFHYAASTTK-EIINLIID--KSTVNLNHLNSDGYTPLHV----ACL-------------- 238
             ..:|.|.||:.:. ::|.::.:  |....:|..:|:||||.:|    |||
Worm   375 EGQNVLHVAATASSGDLIKILWETKKCETMINQTDSNGYTPAYVALINACLSNCQTLRGFGGGIQ 439

  Fly   239 -ADKPENVKALLLAGANVNLNAKDIRKVYK-------TSAPTTVSSFLRTNVSKLYTQDMKYGGT 295
             :|..:....::.|.....|:...:||:.:       .:.|||                   |.|
Worm   440 SSDSTQMANPIIGAMKRGKLDEVSLRKMLELKQDGLTETEPTT-------------------GNT 485

  Fly   296 PLHWCSSRETLHALIME----GCDVNATNFDGRTALHVMVARNRFECVVTLLAHDAEIDVLDKDG 356
            .:| |:..:....|:||    ..|..|.|...:|.||..|.::....|:||.|:..::|..|.:|
Worm   486 VIH-CAINKKCLILLMEKFRDQTDPEARNALQQTPLHTFVIKDELGLVMTLSAYGVDMDAQDING 549

  Fly   357 NAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDEILYILHSVGAKRCK 421
            |..||.|:.:....|.:.|:..|...::||:..::|||:...........:|:..|...||..|.
Worm   550 NTPLHCAVTRGNTEIARMLLCLGAKPDIKNRYKESPRHIAARLTEKEAKMDIVRALIICGAGACD 614

  Fly   422 DTGSKCPPGCNAKGNYN------GIPPEAPESVEQREHIEHMLATTSRQMMGGFLNAAANGILEK 480
            |....|..||..|....      |......:|:|.|....|:..           |||:
Worm   615 DGFIGCAFGCMHKTGLTSCKTQLGSSSSDEQSMEDRVKDIHVSD-----------NAAS------ 662

  Fly   481 QQPAQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKENSSDSLASGSQKSAVSSPEQLPSP 545
               |....|:|.:.:|    :.:|......|:....|...:...:.|....:|          ..
Worm   663 ---APYEFVLDPDTQL----VEEAYAERNETRAFPHEEALKRVKNKLKELVEK----------KK 710

  Fly   546 TSPIAAEIGDKPYGRGRLLCLDGGGIRGLVLVQMLLEIEKLSRTPIIHMFDWIAGTSTGGILALA 610
            ||.:...:|           ||||||||||.||||:.:|.....|:|..||||..||||..:...
Worm   711 TSNVINVLG-----------LDGGGIRGLVTVQMLICLEAFLDRPLIDYFDWIGATSTGCYIMST 764

  Fly   611 LGCGKTMRQCMGLYLRMKEQCFVG-SRPYNSEFFESILKDNLGEFNVMTDIKHPKIMVTGVMADR 674
            :..|.::|:....||..|:|.|.. :|||:::..|:.::...|...:|.|||:|:...|.|.||.
Worm   765 MMTGGSLRKAQRYYLMFKDQLFDSWTRPYDTKTLETFIQRAFGADRLMGDIKYPRFFCTTVRADT 829

  Fly   675 KPVDLHLFRNYTSASDILGIVTPIN---NRRIPPPQPSEQLVWRAARATGAAPSYFRAF-GRFLD 735
            .||.|.|.|||.         .||:   |..:....|:|..:|:|.|.:.|||:||.|. |:|:|
Worm   830 FPVQLELLRNYR---------LPISEKENNDLGFTDPNELTIWKATRRSSAAPTYFSASEGKFID 885

  Fly   736 GGLIANNPTLDAMTEIHEYNMALRSAGRESEAIPVSVVMSLGTGHIPVTELKDIDVFRPESIWDT 800
            ||:|:|||.||.|::|..||...:......:.:.:..|:|:|||..|:..: |..||....::..
Worm   886 GGMISNNPVLDLMSDIGFYNTTCQKMRIPEKMVDMGCVLSVGTGITPICPV-DPSVFEMNDLFGM 949

  Fly   801 AKLAYGISTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQLSEDIAMDEKDDQKLINML 865
            .:   |:..:..:::||||.::|..:.|:|.||.::|:||:|.|..:.:|:.:|..||..|..::
Worm   950 LR---GMKNLSLVVIDQATATEGAPITRSRTWCHSLGVPYYRLNAPIFKDVILDTNDDYDLAKIM 1011

  Fly   866 WHTKAYMHANRNKIIEMINFLK 887
            |.:..|.|.::....|:...||
Worm  1012 WDSVVYSHTHKKDFQELAELLK 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786	17/68 (25%)
		Ank_2	168..258	CDD:289560	26/117 (22%)
		ANK	191..343	CDD:238125	44/190 (23%)
		ANK repeat	228..261	CDD:293786	11/51 (22%)
		ANK	291..412	CDD:238125	34/124 (27%)
		ANK repeat	292..320	CDD:293786	9/31 (29%)
		Ank_2	297..386	CDD:289560	26/92 (28%)
		ANK repeat	322..353	CDD:293786	9/30 (30%)
		ANK repeat	355..386	CDD:293786	8/30 (27%)
		ANK repeat	388..417	CDD:293786	5/28 (18%)
		Pat_PNPLA9	563..876	CDD:132851	114/317 (36%)
ipla-3	NP_001367163.1	ANK repeat	342..373	CDD:293786	10/38 (26%)
		Ank_2	347..442	CDD:403870	24/99 (24%)
		ANK repeat	375..409	CDD:293786	7/33 (21%)
		ANKYR	<466..614	CDD:223738	41/167 (25%)
		ANK repeat	483..513	CDD:293786	9/30 (30%)
		ANK repeat	517..546	CDD:293786	9/28 (32%)
		Ank_4	518..569	CDD:372654	16/50 (32%)
		ANK repeat	548..579	CDD:293786	8/30 (27%)
		ANK repeat	581..610	CDD:293786	5/28 (18%)
		Pat_PNPLA9	717..1022	CDD:132851	115/328 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I2998
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2635
Inparanoid	1	1.050	286	1.000	Inparanoid score	I1721
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49455
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005157
OrthoInspector	1	1.000	-	-		otm14354
orthoMCL	1	0.900	-	-		OOG6_104994
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3123
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.900