Protein Alignment iPLA2-VIA and ipla-3

DIOPT Version :10

• Sequence 1: NP_729565.2
• Gene: iPLA2-VIA / 39160
• FlyBaseID: FBgn0036053
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001367163.1
• Gene: ipla-3 / 180354
• WormBaseID: WBGene00012319
• Length: 1047
• Species: Caenorhabditis elegans
• Alignment Length: 932
• Identity: 249/932 - (26%)
• Similarity: 401/932 - (43%)
• Gaps: 190/932 - (20%)

  Fly    22 DQPANKVVEIKSEALGTLQVLARDDAMLLFAPPFNSSNEKRAVYEIILQRPTSDSNTTSFSLYRS 86
            |..|.:..|:|::.|..|.:..           :|.:|||..:                 ||:||
 Worm   226 DLRAKEEEELKNKPLYHLAITL-----------YNENNEKYVM-----------------SLFRS 262

  Fly    87 PVQ----------QEAEERFNAFLQRLPVFVSIVKEYYNVNGLQKACDALADNPSWTLSHLIAYF 141
            ...          :|..|.|..|    |..|:| |:|     |......|.||.:|...|:.:..
 Worm   263 HKLADVVALCERCRENPELFRVF----PKNVNI-KDY-----LHTIFHELRDNMTWKSVHISSKI 317

  Fly   142 NLVDYISN------PKMLQCVDQADAATLMSPFQLAIKQGHMEMVKALLPLSKLEH-LDIN---- 195
            .|::|..|      .|.|..:.|.:.   :||..:|::...:|.|..:     |:| .|||
 Worm   318 GLLEYFENMKEHKLKKYLNLIVQPEG---LSPLMIAVQNTQIETVSWM-----LDHGADINILSS 374

  Fly   196 -SNSVFHYAASTTK-EIINLIID--KSTVNLNHLNSDGYTPLHV----ACL-------------- 238
             ..:|.|.||:.:. ::|.::.:  |....:|..:|:||||.:|    |||
 Worm   375 EGQNVLHVAATASSGDLIKILWETKKCETMINQTDSNGYTPAYVALINACLSNCQTLRGFGGGIQ 439

  Fly   239 -ADKPENVKALLLAGANVNLNAKDIRKVYK-------TSAPTTVSSFLRTNVSKLYTQDMKYGGT 295
             :|..:....::.|.....|:...:||:.:       .:.|||                   |.|
 Worm   440 SSDSTQMANPIIGAMKRGKLDEVSLRKMLELKQDGLTETEPTT-------------------GNT 485

  Fly   296 PLHWCSSRETLHALIME----GCDVNATNFDGRTALHVMVARNRFECVVTLLAHDAEIDVLDKDG 356
            .:| |:..:....|:||    ..|..|.|...:|.||..|.::....|:||.|:..::|..|.:|
 Worm   486 VIH-CAINKKCLILLMEKFRDQTDPEARNALQQTPLHTFVIKDELGLVMTLSAYGVDMDAQDING 549

  Fly   357 NAALHIAIEKKLVPIVQCLVVFGCDINLKNKDGKTPRHMVGNDASGNKDDEILYILHSVGAKRCK 421
            |..||.|:.:....|.:.|:..|...::||:..::|||:...........:|:..|...||..|.
 Worm   550 NTPLHCAVTRGNTEIARMLLCLGAKPDIKNRYKESPRHIAARLTEKEAKMDIVRALIICGAGACD 614

  Fly   422 DTGSKCPPGCNAKGNYN------GIPPEAPESVEQREHIEHMLATTSRQMMGGFLNAAANGILEK 480
            |....|..||..|....      |......:|:|.|....|:..           |||:
 Worm   615 DGFIGCAFGCMHKTGLTSCKTQLGSSSSDEQSMEDRVKDIHVSD-----------NAAS------ 662

  Fly   481 QQPAQKPVVVDTEKELKGQSIMDALLGMFTTKVNADEMKKENSSDSLASGSQKSAVSSPEQLPSP 545
               |....|:|.:.:|    :.:|......|:....|...:...:.|....:|          ..
 Worm   663 ---APYEFVLDPDTQL----VEEAYAERNETRAFPHEEALKRVKNKLKELVEK----------KK 710

  Fly   546 TSPIAAEIGDKPYGRGRLLCLDGGGIRGLVLVQMLLEIEKLSRTPIIHMFDWIAGTSTGGILALA 610
            ||.:...:|           ||||||||||.||||:.:|.....|:|..||||..||||..:...
 Worm   711 TSNVINVLG-----------LDGGGIRGLVTVQMLICLEAFLDRPLIDYFDWIGATSTGCYIMST 764

  Fly   611 LGCGKTMRQCMGLYLRMKEQCFVG-SRPYNSEFFESILKDNLGEFNVMTDIKHPKIMVTGVMADR 674
            :..|.::|:....||..|:|.|.. :|||:::..|:.::...|...:|.|||:|:...|.|.||.
 Worm   765 MMTGGSLRKAQRYYLMFKDQLFDSWTRPYDTKTLETFIQRAFGADRLMGDIKYPRFFCTTVRADT 829

  Fly   675 KPVDLHLFRNYTSASDILGIVTPIN---NRRIPPPQPSEQLVWRAARATGAAPSYFRAF-GRFLD 735
            .||.|.|.|||.         .||:   |..:....|:|..:|:|.|.:.|||:||.|. |:|:|
 Worm   830 FPVQLELLRNYR---------LPISEKENNDLGFTDPNELTIWKATRRSSAAPTYFSASEGKFID 885

  Fly   736 GGLIANNPTLDAMTEIHEYNMALRSAGRESEAIPVSVVMSLGTGHIPVTELKDIDVFRPESIWDT 800
            ||:|:|||.||.|::|..||...:......:.:.:..|:|:|||..|:..: |..||....::..
 Worm   886 GGMISNNPVLDLMSDIGFYNTTCQKMRIPEKMVDMGCVLSVGTGITPICPV-DPSVFEMNDLFGM 949

  Fly   801 AKLAYGISTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQLSEDIAMDEKDDQKLINML 865
            .:   |:..:..:::||||.::|..:.|:|.||.::|:||:|.|..:.:|:.:|..||..|..::
 Worm   950 LR---GMKNLSLVVIDQATATEGAPITRSRTWCHSLGVPYYRLNAPIFKDVILDTNDDYDLAKIM 1011

  Fly   866 WHTKAYMHANRNKIIEMINFLK 887
            |.:..|.|.::....|:...||
 Worm  1012 WDSVVYSHTHKKDFQELAELLK 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANKYR	143..418	CDD:440430	76/319 (24%)
		ANK repeat	166..226	CDD:293786	17/68 (25%)
		ANK repeat	228..261	CDD:293786	11/51 (22%)
		ANK repeat	292..320	CDD:293786	9/31 (29%)
		ANK repeat	322..353	CDD:293786	9/30 (30%)
		ANK repeat	355..386	CDD:293786	8/30 (27%)
		ANK repeat	388..417	CDD:293786	5/28 (18%)
		Pat_PNPLA9	563..876	CDD:132851	114/317 (36%)
ipla-3	NP_001367163.1	Ank_2	312..395	CDD:463710	22/90 (24%)
		ANK repeat	342..373	CDD:293786	10/38 (26%)
		ANKYR	362..610	CDD:440430	64/272 (24%)
		ANK repeat	375..409	CDD:293786	7/33 (21%)
		ANK repeat	483..513	CDD:293786	9/30 (30%)
		ANK repeat	517..546	CDD:293786	9/28 (32%)
		ANK repeat	548..579	CDD:293786	8/30 (27%)
		ANK repeat	581..610	CDD:293786	5/28 (18%)
		Pat_PNPLA9	717..1022	CDD:132851	115/328 (35%)