DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iPLA2-VIA and ipla-7

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001369902.1	Gene:	ipla-7 / 177869	WormBaseID:	WBGene00011423	Length:	471	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	138/492 - (28%)
Similarity:	221/492 - (44%)	Gaps:	101/492 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 EQREHIEHMLATTSRQMMGGFLNAAANGILEK-QQPAQKP-VVVDTEKELKGQSIMDA------- 504
            ::.|.:::|:|         ||.:|.....|| .|..|.| ..:.|.|.|:..|:..:
Worm    14 KKAERVDNMIA---------FLKSAVQAQKEKGAQAEQAPGNAMMTSKLLEIWSVPQSTITEMRL 69

  Fly   505 --LLGMFTTKVNADEMKKENSSDSLASGS--QKSAVSSPEQLPSPTSPIAAEIGDKPYGRGRL-- 563
              .||...|.:..|:..::..:|.:.:||  ::.||.....|     ..:..|.::.|.|..:
Worm    70 LLTLGADPTPLFKDDFGEKTLADRIDNGSVCEECAVKFKSFL-----EFSGVIFEEMYERTPIQI 129

  Fly   564 -----------LCLDGGGIRGLVLVQMLLEIEK--LSRTPIIHMFDWIAGTSTGGILALALGCGK 615
                       |||||||:||||.|..||...:  |....:.::|||..|||||.:|||::....
Worm   130 NRSKKVDGVMALCLDGGGMRGLVSVVCLLYASRRLLGDETLPNLFDWFIGTSTGSMLALSMVNKI 194

  Fly   616 TMRQCMGLYLRMKEQCFV-GSRPYNSEFFESILKDN-----------LGE-FNVMTDIKHP-KIM 666
            ::.:|...|..||.|.|: ||.      .:.:|.|.           ||: |...|..:.| ::.
Worm   195 SISECFFQYWDMKSQIFLRGST------VKRLLGDQVAVQTKNIDKVLGDCFPTQTLQECPTRLT 253

  Fly   667 VTGVMADRKPVDLHLFRNYTSASDILGIVTPINNRRIPPPQPSEQLVWRAARATGAAPSYFRAF- 730
            :..:.....|..||:|||| |.:...|  .|:|       :..:.|...||||:.|||:||..|
Worm   254 IPALDISTAPARLHVFRNY-SFTKPFG--APLN-------EDQDVLFREAARASSAAPTYFEPFI 308

  Fly   731 -GR--FLDGGLIANNPTLDAMTEIHEYNMALRSAGRESEAIPVSVVMSLGTGHIPVTELKDIDVF 792
             |.  .:||..:||.| |:.:  ..||:    |..:..:.|.::.|:|:|||...:.|.|
Worm   309 YGNKVLVDGSFVANYP-LNVL--FKEYD----SFSKHQQPIHLAGVLSIGTGEPALAERK----- 361

  Fly   793 RPESIWDTAK----LAYGISTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQLSEDIAM 853
                 :.:.|    .|..|..:..|:::|....|...|:.|:..|....||:.|.:|: ...:.:
Worm   362 -----YKSGKSIRAKAMNIGHLSTLILEQVVGQDLTAVEMAQDRCHAHNIPFNRLSPK-GISVRI 420

  Fly   854 DEKDDQKLINMLWHTKAYMHANRNKII---EMINFLK 887
            |:.||.||::|:|.|..|:..|.::|.   |||..||
Worm   421 DQIDDSKLMDMIWTTLIYLTENVHEIDQLGEMIYKLK 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786
		Ank_2	168..258	CDD:289560
		ANK	191..343	CDD:238125
		ANK repeat	228..261	CDD:293786
		ANK	291..412	CDD:238125
		ANK repeat	292..320	CDD:293786
		Ank_2	297..386	CDD:289560
		ANK repeat	322..353	CDD:293786
		ANK repeat	355..386	CDD:293786
		ANK repeat	388..417	CDD:293786
		Pat_PNPLA9	563..876	CDD:132851	103/349 (30%)
ipla-7	NP_001369902.1	Patatin_and_cPLA2	141..442	CDD:416256	103/334 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840