DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment iPLA2-VIA and ANKRD22

DIOPT Version :9

Sequence 1:	NP_729565.2	Gene:	iPLA2-VIA / 39160	FlyBaseID:	FBgn0036053	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_653191.2	Gene:	ANKRD22 / 118932	HGNCID:	28321	Length:	191	Species:	Homo sapiens

Alignment Length:	177	Identity:	46/177 - (25%)
Similarity:	67/177 - (37%)	Gaps:	42/177 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 DKSTVNLNHLNSDGY---TPLHVACLADKPENVKALLLAGANVNL-NAKD-------IRK----- 264
            |.|..|:    .||:   |||..||.......|..||...||||| |.|:       ::|
Human    28 DSSYANV----QDGFNGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFI 88

  Fly   265 ----VYKTSAPTTVSSFLRTNVSKLYTQDMKYGGTPLHWCSSRETLHALIME-GCDVNATNFDGR 324
                :........:..||..:.:|                 ..|.|..:::: |.:||||:..|.
Human    89 DYLLIILLMPVLLIGYFLMVSKTK-----------------QNEALVRMLLDAGVEVNATDCYGC 136

  Fly   325 TALHVMVARNRFECVVTLLAHDAEIDVLDKDGNAALHIAIEKKLVPI 371
            ||||..........:..||...|:..:.:|.|.::|.||...|...|
Human   137 TALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIARRLKFSQI 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iPLA2-VIA	NP_729565.2	ANK repeat	166..226	CDD:293786	3/9 (33%)
		Ank_2	168..258	CDD:289560	18/45 (40%)
		ANK	191..343	CDD:238125	36/147 (24%)
		ANK repeat	228..261	CDD:293786	16/36 (44%)
		ANK	291..412	CDD:238125	22/82 (27%)
		ANK repeat	292..320	CDD:293786	6/28 (21%)
		Ank_2	297..386	CDD:289560	22/76 (29%)
		ANK repeat	322..353	CDD:293786	8/30 (27%)
		ANK repeat	355..386	CDD:293786	6/17 (35%)
		ANK repeat	388..417	CDD:293786
		Pat_PNPLA9	563..876	CDD:132851
ANKRD22	NP_653191.2	Ank_4	5..60	CDD:372654	11/35 (31%)
		Ank_2	<39..>175	CDD:423045	37/152 (24%)
		ANK repeat	39..70	CDD:293786	13/30 (43%)
		ANK 1	39..68		11/28 (39%)
		ANK repeat	72..132	CDD:293786	11/76 (14%)
		ANK 2	72..100		2/27 (7%)
		ANK 3	101..130		7/45 (16%)
		ANK repeat	134..165	CDD:293786	8/30 (27%)
		ANK 4	134..163		8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156348
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930