DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10809 and TNKS

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_003738.2	Gene:	TNKS / 8658	HGNCID:	11941	Length:	1327	Species:	Homo sapiens

Alignment Length:	360	Identity:	89/360 - (24%)
Similarity:	136/360 - (37%)	Gaps:	109/360 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PPSPMSMAMVLAKSTPMPMPTSASKGIMITP--------------PP------------------ 56
            ||.|..::..||..|....||::......:|              ||
Human    29 PPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTT 93

  Fly    57 ---------PAMPPTPTSS-----PNTHGEWPHMNINLNLNMSSNPSTNASFQLSRDRGEHFALP 107
                     |.:|...|||     ||..|.    ..|.:.:.||:|::::|..
Human    94 STICTVAAAPVVPAVSTSSAAGVAPNPAGS----GSNNSPSSSSSPTSSSSSS------------ 142

  Fly   108 HLPPLPLNPNASNAEYLPSLIHPSTLPSG-----------SKSFKMRPRMQ--------RLKHSY 153
                 |.:|.:|.||...:....||.|.|           :.|..:|..::        |:|...
Human   143 -----PSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLV 202

  Fly   154 SYSNIIVQS-NGRK---LRTAASTCNIELLNRILEGGANPNAADEYNRSPLHLAACRGYIPIVQQ 214
            ..:|:..:. .|||   |..||.....:::..:|:.|||.:|.|:....|||.|...|:..:|..
Human   203 DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSL 267

  Fly   215 LLKYGANPNVVDSLGNTPLHLAVISASSNNFNVVVGVLLQGGASVHMYDRSNKSPLELAEAKLR- 278
            ||..||:||..|:...||||.|.|....:    |..||||.||..::.:...||.|:||:...:
Human   268 LLCQGADPNARDNWNYTPLHEAAIKGKID----VCIVLLQHGADPNIRNTDGKSALDLADPSAKA 328

  Fly   279 LLRNRYDHPTPETAKILED---------MCMLTTL 304
            :|...|     :..::||.         |.:||.|
Human   329 VLTGEY-----KKDELLEAARSGNEEKLMALLTPL 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	35/95 (37%)
		ANK repeat	167..193	CDD:293786	8/25 (32%)
		ANK	170..276	CDD:238125	39/105 (37%)
		ANK repeat	195..226	CDD:293786	12/30 (40%)
		ANK repeat	228..263	CDD:293786	13/34 (38%)
TNKS	NP_003738.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		11/61 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..173		18/81 (22%)
		ANK 1. /evidence=ECO:0000255	181..209		4/27 (15%)
		ANK	208..322	CDD:238125	41/117 (35%)
		ANK 2. /evidence=ECO:0000255	215..244		9/28 (32%)
		ANK repeat	218..246	CDD:293786	8/27 (30%)
		Ank_2	220..312	CDD:289560	35/95 (37%)
		ANK repeat	248..279	CDD:293786	12/30 (40%)
		ANK 3. /evidence=ECO:0000255	248..277		11/28 (39%)
		ANK	276..455	CDD:238125	28/92 (30%)
		ANK repeat	281..312	CDD:293786	13/34 (38%)
		ANK 4. /evidence=ECO:0000255	281..310		13/32 (41%)
		ANK 5. /evidence=ECO:0000255	335..364		6/24 (25%)
		Ank_4	339..389	CDD:290365	6/20 (30%)
		ANK 6. /evidence=ECO:0000255	368..397
		ANK repeat	371..399	CDD:293786
		Ank_2	373..465	CDD:289560
		ANK repeat	401..432	CDD:293786
		ANK 7. /evidence=ECO:0000255	401..430
		ANK repeat	434..465	CDD:293786
		ANK 8. /evidence=ECO:0000255	434..463
		ANK 9. /evidence=ECO:0000255	521..553
		ANK	523..639	CDD:238125
		ANK repeat	523..555	CDD:293786
		Ank_2	526..619	CDD:289560
		ANK repeat	557..588	CDD:293786
		ANK 10. /evidence=ECO:0000255	557..586
		ANK repeat	590..619	CDD:293786
		ANK 11. /evidence=ECO:0000255	590..619
		Ank_2	595..714	CDD:289560
		ANK 12. /evidence=ECO:0000255	621..647
		ANK 13. /evidence=ECO:0000255	649..679
		ANK	676..801	CDD:238125
		ANK 14. /evidence=ECO:0000255	683..712
		ANK repeat	686..714	CDD:293786
		Ank_2	688..780	CDD:289560
		ANK repeat	716..747	CDD:293786
		ANK 15. /evidence=ECO:0000255	716..745
		ANK repeat	749..780	CDD:293786
		ANK 16. /evidence=ECO:0000255	749..778
		ANK 17. /evidence=ECO:0000255	782..810
		Ank_4	803..857	CDD:290365
		ANK	829..953	CDD:238125
		ANK repeat	836..867	CDD:293786
		ANK 18. /evidence=ECO:0000255	836..865
		Ank_2	841..933	CDD:289560
		ANK repeat	869..900	CDD:293786
		ANK 19. /evidence=ECO:0000255	869..898
		ANK repeat	902..933	CDD:293786
		ANK 20. /evidence=ECO:0000255	902..931
		ANK 21. /evidence=ECO:0000255	935..964
		SAM_tankyrase1,2	1024..1089	CDD:188923
		SAM	1030..1087	CDD:197735
		tankyrase_like	1091..1313	CDD:238718
		PARP	1105..1308	CDD:279038
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910