DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10809 and SPT23

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_012905.1	Gene:	SPT23 / 853848	SGDID:	S000001503	Length:	1082	Species:	Saccharomyces cerevisiae

Alignment Length:	367	Identity:	75/367 - (20%)
Similarity:	138/367 - (37%)	Gaps:	61/367 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VEMSMPPSPMSMAMVLAKSTPMPMPTSA-SKGIMITPPPPAMPPTPTSSPNTHGEWPHMNINLNL 82
            :|:::..|.....:::.....:.:.:.. ::..|:|..||:..|.|............|..|.|.
Yeast   524 IEVTLLGSKFKQGLIIKFGENIALSSQCWNESTMVTYLPPSSKPGPVLVTIVDPSETSMRNNSNS 588

  Fly    83 NMSSNPSTNASFQLSRDRGEHFALPHLPP--------------LPLNPNASNAEYLPSLIHPSTL 133
            ::|::.|||....|::..||.....::..              |.:|....:|..:...|..|..
Yeast   589 SVSTSNSTNDILHLNKYTGEKAIFTYVDDTDRQLIELALQIVGLKMNGKLEDARNIAKRIVGSDS 653

  Fly   134 PSGSKSFKMRPRMQRLKHSYSYSNIIVQSNGRKLRTAA----------STCNIELLNRILEGGAN 188
            ...:.:..:..:...|.   ||:|::...|..:|.|..          ||.|:.:
Yeast   654 SPSNNNAGLHSQNSSLN---SYTNMMRNINDEQLITEVIKSFKRNNNLSTVNLSM---------- 705

  Fly   189 PNAADEYNRSPLHLAACRGYIPIVQQLLKYGANPNVVDSLGNTPLHLAVISASSNNFNVVVGVLL 253
               .|...|:.|||||...:..:|..|:|||::.|..|..|.||||:|.|:....    ::.:||
Yeast   706 ---CDVRGRTLLHLAAFNNWYSLVSLLIKYGSHLNDQDLFGFTPLHMACINGDLR----IIRLLL 763

  Fly   254 QGGASVHMYDRSNKSPLELAEAKLRLLRNRYDHPTPETAKILEDMCMLTTLILRYMVKQQRELED 318
            :...::....|:.....:.......:.:.||.:  .||: :.:|       ||..:.|......|
Yeast   764 ECNVNIMKKTRNGFIAKQFFLMNYTVNKTRYSN--YETS-LFDD-------ILTRLTKNTTGSSD 818

  Fly   319 LSALEKRL------QNLSTSDDQEQVVSQTADELLASVERLS 354
            ....|:.:      .:|...||.:....|....|||....|:
Yeast   819 TQPFERNVSQSSFNSSLFDDDDADHDYVQERKYLLADSAALA 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	28/105 (27%)
		ANK repeat	167..193	CDD:293786	5/35 (14%)
		ANK	170..276	CDD:238125	27/115 (23%)
		ANK repeat	195..226	CDD:293786	12/30 (40%)
		ANK repeat	228..263	CDD:293786	9/34 (26%)
SPT23	NP_012905.1	ANKYR	79..>209	CDD:223738
		IPT	508..578	CDD:238050	8/53 (15%)
		PLN03192	<612..>765	CDD:215625	38/172 (22%)
		Ank_2	694..772	CDD:403870	26/94 (28%)
		ANK repeat	709..740	CDD:293786	12/30 (40%)
		ANK repeat	742..767	CDD:293786	9/28 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5638
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030