DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10809 and AKR2B

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_179331.1	Gene:	AKR2B / 816246	AraportID:	AT2G17390	Length:	344	Species:	Arabidopsis thaliana

Alignment Length:	330	Identity:	79/330 - (23%)
Similarity:	124/330 - (37%)	Gaps:	91/330 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NDSSGVESAKEEVEMSMPPSPMSMAMVLAKSTPMPMPTSASKG----------------IMITPP 55
            ||.|..|.|:   :::..||...:|..|.:|    :||.:.:|                :|..|.
plant    61 NDPSIKELAE---QIAKDPSFNQLAEQLQRS----VPTGSHEGGLPNFDPQQYMQTMQQVMENPE 118

  Fly    56 --------PPAMPPTPTSSPNTHGEWPHMNINLNLNMSSNPSTNASF-----QLSRDRGEHFALP 107
                    ..|:...|..||             .|....||:.:..|     |:..|       |
plant   119 FRTMAERLGNALVQDPQMSP-------------FLEALGNPAASEQFAERMAQMKED-------P 163

  Fly   108 HLPPLPL-----NPNA-----SNAEYLPSLIHPSTLPSGS-KSFKMRPRMQRLKHSYSYSNIIVQ 161
            .|.|:..     .|:|     ::.:.|..|.....:..|: ::....|  :..:......:|:.|
plant   164 ELKPILAEIDAGGPSAMMKYWNDKDVLAKLGEAMGIAVGADQTVAAEP--EEAEEGEEEESIVHQ 226

  Fly   162 SNGRKLRTAASTCNIELLNRILEGGANPNAADEYNRSPLHLAACRGYIPIVQQLLKYGANPNVVD 226
            :        ||..::|.|...|..|.|.:..|...|:.||.|...|.:...|.||..|||.|.:|
plant   227 T--------ASLGDVEGLKAALASGGNKDEEDSEGRTALHFACGYGEVRCAQVLLDAGANANAID 283

  Fly   227 SLGNTPLHLAVISASSNNFNVVVGVLLQGGASVHMYDRSNKSPLELAEAKLRLLRNRYDHPTPET 291
            ...|||||.    |:.......|.:||:.||:|...:..||:|:::|.     |.|:.|     .
plant   284 KNKNTPLHY----AAGYGRKECVSLLLENGAAVTQQNMDNKNPIDVAR-----LNNQLD-----V 334

  Fly   292 AKILE 296
            .|:||
plant   335 VKLLE 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	33/95 (35%)
		ANK repeat	167..193	CDD:293786	7/25 (28%)
		ANK	170..276	CDD:238125	37/105 (35%)
		ANK repeat	195..226	CDD:293786	12/30 (40%)
		ANK repeat	228..263	CDD:293786	12/34 (35%)
AKR2B	NP_179331.1	EBP50_C	<2..>49	CDD:286142
		ANK	225..338	CDD:238125	42/134 (31%)
		Ank_2	225..316	CDD:289560	34/102 (33%)
		ANK repeat	252..283	CDD:293786	12/30 (40%)
		ANK repeat	285..316	CDD:293786	12/34 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910