DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10809 and caiap

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_001020663.1	Gene:	caiap / 557416	ZFINID:	ZDB-GENE-041014-19	Length:	744	Species:	Danio rerio

Alignment Length:	298	Identity:	65/298 - (21%)
Similarity:	103/298 - (34%)	Gaps:	83/298 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SAKEEVEMSMPPSPMSMAMVLAKSTPMPMPTSASKGIMITPPPPAMPP---TPTSSPNTHGEWPH 75
            |.|.:::..:|....|:.:.:...:.........|||    .|....|   ||.....:|.:...
Zfish   432 SKKAKLDERLPNQMSSLHLAVQSGSIQIAQILLHKGI----DPNISGPKDQTPLHLSASHNQPAM 492

  Fly    76 MNINLNLNMSSNPSTNASFQLSRDRGEHFALPHLPPLPLNPNASNAEYLPSLIHPSTLPSGSKSF 140
            |.:.|.:....||.|...|               .||.|.....:.|.:..|:.
Zfish   493 MALLLRVGAQLNPVTQDGF---------------TPLHLASQNGHTEAVAQLLE----------- 531

  Fly   141 KMRPRMQRLKHSYSYSNIIVQSNGRKLRT----AASTCNIELLNRILEGGANPNAADEYNRSPLH 201
                           :...|.:..::.||    ||....:.::..:|..||..||::...::|||
Zfish   532 ---------------AKADVHAKDKQGRTALHWAAEQGEVAIIQSLLAAGAYSNASEREKKTPLH 581

  Fly   202 LAACRGYIPIVQQLLKYGANPNVVDSLGNTPLHLA----------VISASSNNFNV--------- 247
            |||..|:...|..||...|.....|..|.:|||.|          |:.|||.:.||
Zfish   582 LAAAEGHTKAVSALLAGKAKVGAKDMDGCSPLHYAARNGKERAGSVLLASSKSKNVDDKNVWRRT 646

  Fly   248 ------------VVGVLLQGGASVHMYDRSNKSPLELA 273
                        :||:||:..|.::..|.:..:||..|
Zfish   647 ALHLAAEHGHEALVGILLENKAKINALDNNKDTPLHCA 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	37/130 (28%)
		ANK repeat	167..193	CDD:293786	9/29 (31%)
		ANK	170..276	CDD:238125	39/135 (29%)
		ANK repeat	195..226	CDD:293786	11/30 (37%)
		ANK repeat	228..263	CDD:293786	16/65 (25%)
caiap	NP_001020663.1	CARD	15..94	CDD:260018
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..146
		ANK 1. /evidence=ECO:0000255	157..185
		ANK repeat	159..187	CDD:293786
		PHA03095	160..>577	CDD:222980	33/189 (17%)
		ANK 2. /evidence=ECO:0000255	189..218
		ANK repeat	191..220	CDD:293786
		ANK repeat	222..253	CDD:293786
		ANK 3. /evidence=ECO:0000255	222..251
		ANK 4. /evidence=ECO:0000255	255..285
		ANK 5. /evidence=ECO:0000255	287..314
		ANK repeat	318..348	CDD:293786
		ANK 6. /evidence=ECO:0000255	318..347
		ANK 7. /evidence=ECO:0000255	377..406
		ANK repeat	379..408	CDD:293786
		ANK repeat	410..441	CDD:293786	2/8 (25%)
		ANK 8. /evidence=ECO:0000255	410..439		2/6 (33%)
		ANK 9. /evidence=ECO:0000255	443..472		5/32 (16%)
		ANK repeat	446..474	CDD:293786	5/31 (16%)
		PHA03095	463..>698	CDD:222980	61/267 (23%)
		ANK 10. /evidence=ECO:0000255	476..505		5/28 (18%)
		ANK repeat	478..507	CDD:293786	7/28 (25%)
		ANK repeat	509..540	CDD:293786	7/71 (10%)
		ANK 11. /evidence=ECO:0000255	509..538		7/69 (10%)
		ANK repeat	542..573	CDD:293786	9/30 (30%)
		ANK 12. /evidence=ECO:0000255	542..571		7/28 (25%)
		ANK repeat	575..606	CDD:293786	11/30 (37%)
		ANK 13. /evidence=ECO:0000255	575..604		11/28 (39%)
		ANK repeat	608..639	CDD:293786	11/30 (37%)
		ANK 14. /evidence=ECO:0000255	608..637		9/28 (32%)
		ANK repeat	641..674	CDD:293786	5/32 (16%)
		ANK 15. /evidence=ECO:0000255	643..672		5/28 (18%)
		ANK repeat	676..711	CDD:293786	3/9 (33%)
		ANK 16. /evidence=ECO:0000255	676..705		3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910