DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10809 and ANKRD54

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	XP_011528179.1	Gene:	ANKRD54 / 129138	HGNCID:	25185	Length:	344	Species:	Homo sapiens

Alignment Length:	240	Identity:	62/240 - (25%)
Similarity:	106/240 - (44%)	Gaps:	64/240 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 RKLRTAASTCNIELLNRILEGGANPNAADEYNRSPLHLAACRGYIPIVQQLLKYGANPN------ 223
            ::||.:|:..::|.:.::||.||:|.|||:..|:.||.|:|.|...|.|:.|...:.|.
Human   112 KRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIGQEALPKSSVPGPQGFAH 176

  Fly   224 -----------VVDSLGNTPLHL------AVISASSNNFNVVVGV-----------------LLQ 254
                       :...:|....|.      ....:|.:.:..|.|.                 |:.
Human   177 ELCCSWTMVLILTSEMGWGTRHCTWRPAPTTFLSSPHCYEEVCGFFPSLSSFSPSPPECSPQLVP 241

  Fly   255 GGASVHMYDRSNKSPLELAEAKLRLLRNRYDHPTPETAKILE----DMCMLTTLILRYMVK---- 311
            .||.|...||:.::||.||::||.:|:..:       |:.||    ::..:..::..|:.:
Human   242 AGARVDALDRAGRTPLHLAKSKLNILQEGH-------AQCLEAVRLEVKQIIHMLREYLERLGQH 299

  Fly   312 QQRE-LEDLSALEKRLQNLSTSDDQEQVVSQTADELLASVERLSI 355
            :||| |:||..   |||..||.:..::|.     :||||...||:
Human   300 EQRERLDDLCT---RLQMTSTKEQVDEVT-----DLLASFTSLSL 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	31/135 (23%)
		ANK repeat	167..193	CDD:293786	10/25 (40%)
		ANK	170..276	CDD:238125	35/145 (24%)
		ANK repeat	195..226	CDD:293786	10/47 (21%)
		ANK repeat	228..263	CDD:293786	9/57 (16%)
ANKRD54	XP_011528179.1	ANK	118..276	CDD:238125	39/164 (24%)
ANKRD54	XP_011528179.1	Ank_2	118..>174	CDD:289560	20/55 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BJ6N
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4877
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1559479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto88769
orthoMCL	1	0.900	-	-		OOG6_108203
Panther	1	1.100	-	-	LDO	PTHR24197
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.830