DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10809 and Ank3

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	XP_036011414.1	Gene:	Ank3 / 11735	MGIID:	88026	Length:	4691	Species:	Mus musculus

Alignment Length:	446	Identity:	93/446 - (20%)
Similarity:	159/446 - (35%)	Gaps:	142/446 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GVESAKEEVEMSMPPSPMSMAMVLAKSTPMPMPTSASKGIMITPPPPAMPPTPTSSPNTHGEWPH 75
            |..|..|:|          :.|:|.:|.|:...|...    ::|...|          |.|:  |
Mouse   316 GARSGHEQV----------VEMLLDRSAPILSKTKNG----LSPLHMA----------TQGD--H 354

  Fly    76 MN---INLNLNMSSNPSTN---ASFQLSRDRGEHFALPHLPPLPLNPNASNAEYLPSLIHPSTLP 134
            :|   :.|..|:..:..||   .:..::...|.:.....|.....:|||.      :|...:.|.
Mouse   355 LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKASPNAK------ALNGFTPLH 413

  Fly   135 SGSKSFKMRPRMQRLKHSYSYSNIIVQSNGRKLRTAASTCNIELLNRILEGGANPN--------- 190
            ...|..::|.....|||..|. ..:.:|....:..||...::.::::::..||:||
Mouse   414 IACKKNRIRVMELLLKHGASI-QAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETA 477

  Fly   191 ------------------------AADEYNRSPLHLAACRGYIPIVQQLLKYGANPNVVDSLGNT 231
                                    |..:.:::|||::|..|...||||||:.||:||...:.|.|
Mouse   478 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYT 542

  Fly   232 PLHLAV------------------------------ISASSNNFNVVVGVLLQGGASVHMYDRSN 266
            |||||.                              ::|...... |..:|||..||.....:|.
Mouse   543 PLHLAAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE-VASLLLQKSASPDAAGKSG 606

  Fly   267 KSPLELA----EAKLRLL------------RNRYDHPTPETAKILEDMCMLTTLILRY------- 308
            .:||.:|    ..|:.||            :|.|   ||......::...:.|.:|.|
Mouse   607 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGY---TPLHIAAKKNQMDIATSLLEYGADANAV 668

  Fly   309 ---------MVKQQRELEDLSALEKRLQNLSTSDDQEQVVSQTADELLASVERLSI 355
                     :..|:..::.:|.|..|..|::.|:..    ..|...|.|..:|:::
Mouse   669 TRQGIASVHLAAQEGHVDMVSLLLSRNANVNLSNKS----GLTPLHLAAQEDRVNV 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	36/158 (23%)
		ANK repeat	167..193	CDD:293786	7/58 (12%)
		ANK	170..276	CDD:238125	40/172 (23%)
		ANK repeat	195..226	CDD:293786	15/30 (50%)
		ANK repeat	228..263	CDD:293786	14/64 (22%)
Ank3	XP_036011414.1	Ank_2	59..>304	CDD:423045
		ANK repeat	73..104	CDD:293786
		ANK repeat	106..137	CDD:293786
		ANK repeat	139..164	CDD:293786
		Ank_2	195..>437	CDD:423045	32/153 (21%)
		ANK repeat	205..240	CDD:293786
		ANK repeat	242..273	CDD:293786
		ANK repeat	275..306	CDD:293786
		ANK repeat	308..333	CDD:293786	6/26 (23%)
		ANK repeat	341..372	CDD:293786	8/46 (17%)
		PHA03095	377..>665	CDD:222980	64/298 (21%)
		ANK repeat	377..405	CDD:293786	5/33 (15%)
		ANK repeat	407..438	CDD:293786	7/31 (23%)
		ANK repeat	440..471	CDD:293786	7/30 (23%)
		ANK repeat	473..504	CDD:293786	1/30 (3%)
		ANK repeat	506..537	CDD:293786	15/30 (50%)
		ANK repeat	539..568	CDD:293786	7/28 (25%)
		Ank_2	559..>796	CDD:423045	31/170 (18%)
		ANK repeat	572..601	CDD:293786	7/29 (24%)
		ANK repeat	605..634	CDD:293786	7/28 (25%)
		ANK repeat	638..669	CDD:293786	7/33 (21%)
		ANK repeat	671..702	CDD:293786	5/30 (17%)
		ANK repeat	704..735	CDD:293786	4/21 (19%)
		ANK repeat	737..768	CDD:293786
		ANK repeat	770..798	CDD:293786
		Ank_4	771..823	CDD:372654
		ZU5	1018..1155	CDD:128514
		UPA_2	1377..1506	CDD:375346
		Herpes_BLLF1	<1542..1949	CDD:282904
		DUF2890	3296..>3412	CDD:314108
		Death_ank3	4113..4196	CDD:176781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910