DRSC/TRiP Functional Genomics Resources

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Protein Alignment RasGAP1 and IRA2

DIOPT Version :9

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:NP_014560.1 Gene:IRA2 / 854073 SGDID:S000005441 Length:3079 Species:Saccharomyces cerevisiae


Alignment Length:792 Identity:155/792 - (19%)
Similarity:270/792 - (34%) Gaps:227/792 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   403 PMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADH 467
            |:..:.:...:|.:....|...|.|:...||..|     .|.|...:.:.....|.:.:|...::
Yeast  1602 PVFLRHKMSVLNDNVILSLTNLSNTNVDASLQFT-----LPMGYSGNRNIRNAFLEVFINIVTNY 1661

  Fly   468 VFPLATYDDLMNL-LLESVD---QRPITVSAVSILGELVSGKTEV---AQPLVRLFTHTERIAPI 525
                .||....:| .||:.|   :..|....:|..|..|...:::   |..|:..|........:
Yeast  1662 ----RTYTAKTDLGKLEAADKFLRYTIEHPQLSSFGAAVCPASDIDAYAAGLINAFETRNATHIV 1722

  Fly   526 IKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSK 590
            :..|..:||...:.||.|.|.|:..::.:....|..|..||.:||:|:|.:|:..:...||:..|
Yeast  1723 VAQLIKNEIEKSSRPTDILRRNSCATRSLSMLARSKGNEYLIRTLQPLLKKIIQNRDFFEIEKLK 1787

  Fly   591 IKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGF 655
            .:|..| :..:.....|:..:.|:|:.|....|..|..|..::.:.|.|.||.:..:   ....|
Yeast  1788 PEDSDA-ERQIELFVKYMNELLESISNSVSYFPPPLFYICQNIYKVACEKFPDHAII---AAGSF 1848

  Fly   656 IFLRFFAPAILGP---KLFDLTTERLDAQTSRTLTLISKTIQSLGN----------LVSSRSSQQ 707
            :|||||.||::.|   .:.|::    .....||...::|.||::.|          |.|.:...:
Yeast  1849 VFLRFFCPALVSPDSENIIDIS----HLSEKRTFISLAKVIQNIANGSENFSRWPALCSQKDFLK 1909

  Fly   708 TCKE---EFTVELYKKFCTEQHVD-AVK----------HFL-------------EVISTPSHASS 745
            .|.:   .|..||.:   |::.:| .|:          .||             .|::...|...
Yeast  1910 ECSDRIFRFLAELCR---TDRTIDIQVRTDPTPIAFDYQFLHSFVYLYGLEVRRNVLNEAKHDDG 1971

  Fly   746 SV---------------------HPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQRH-FRL 788
            .:                     .|....:..: |:.::|. |..||..     .:|..|| ||.
Yeast  1972 DIDGDDFYKTTFLLIDDVLGQLGQPKMEFSNEI-PIYIREH-MDDYPEL-----YEFMNRHAFRN 2029

  Fly   789 TTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTT---------- 843
            ...|.:|:.|          :.|..|.|.:...:..|.|     .:||.:.:.|.          
Yeast  2030 IETSTAYSPS----------VHESTSSEGIPIITLTMSN-----FSDRHVDIDTVAYKFLQIYAR 2079

  Fly   844 ----------NCVEEREWFD---------------LLHKICLMNSIRMQYFHPS-AFVSGFYSCC 882
                      :|.|    ||               ||.::...|.|...||:.: .|:..:..| 
Yeast  2080 IWTTKHCLIIDCTE----FDEGGLDMRKFISLVMGLLPEVAPKNCIGCYYFNVNETFMDNYGKC- 2139

  Fly   883 GRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSN---------------MSVLE 932
                         |||...|     |::..|       |..|.||               :.||:
Yeast  2140 -------------LDKDNVY-----VSSKIP-------HYFINSNSDEGLMKSVGITGQGLKVLQ 2179

  Fly   933 SL---LDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLRE----------KA 984
            .:   |..:|.:.       ::.|...|::..:.....|...|..|.. |:|:          ..
Yeast  2180 DIRVSLHDITLYD-------EKRNRFTPVSLKIGDIYFQVLHETPRQY-KIRDMGTLFDVKFNDV 2236

  Fly   985 YAIDRDHRDYKQGIT-------------RQLKYGS-RQAPIGDDNYWHMMRAAGQLNQQHHQQQQ 1035
            |.|.|....:...||             |:|.:.| :...|....|:..:|...:....::....
Yeast  2237 YEISRIFEVHVSSITGVAAEFTVTFQDERRLIFSSPKYLEIVKMFYYAQIRLESEYEMDNNSSTS 2301

  Fly  1036 HQQQQQQQQQQQ 1047
            ......:.:||:
Yeast  2302 SPNSNNKDKQQK 2313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046
C2B_RasA3 280..462 CDD:175977 11/58 (19%)
RasGAP 449..797 CDD:214617 90/416 (22%)
RasGAP_GAP1_like 473..740 CDD:213330 74/313 (24%)
PH 761..859 CDD:278594 26/133 (20%)
PH_GAP1-like 763..867 CDD:269950 28/139 (20%)
BTK 862..897 CDD:128417 6/35 (17%)
IRA2NP_014560.1 RasGAP_Neurofibromin_like 1672..1990 CDD:213341 72/328 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157343027
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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