DRSC/TRiP Functional Genomics Resources

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Protein Alignment RasGAP1 and IRA1

DIOPT Version :9

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:NP_009698.3 Gene:IRA1 / 852437 SGDID:S000000344 Length:3092 Species:Saccharomyces cerevisiae


Alignment Length:756 Identity:166/756 - (21%)
Similarity:271/756 - (35%) Gaps:212/756 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   308 YSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTT---------GSNKSAGSLESSAN 363
            :.|..:..|....:|:  |.:|   :|.|..|::.......|         .|:|...:..|:.:
Yeast  1529 FENLSRPLREMDLQKR--DEDF---LYIDTSIESAKALAYLTHNVPLEIPPSSSKEDWNRSSTVS 1588

  Fly   364 KG--YSIYPVG---GADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQP 423
            .|  ::|...|   .|||.:..||:.|.. ..:::.|.:....|...|      ||.|..:.|  
Yeast  1589 FGNHFTILLKGLEKSADLNQFPVSLRHKI-SILNENVIIALTNLSNAN------VNVSLKFTL-- 1644

  Fly   424 RSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADH-VFP-------LATYDDLMNL 480
                               |.|...:.|..|..||:.::...:: |.|       :...||.:..
Yeast  1645 -------------------PMGYSPNKDIRIAFLRVFIDIVTNYPVNPEKHEMDKMLAIDDFLKY 1690

  Fly   481 LLESVDQRPITVSAVSILGELVSGKTEV---AQPLVRLFTHTERIAPIIKALADHEISHLTDPTT 542
            ::::    ||    ::..|.|.....:|   |...:..|........::..|...||........
Yeast  1691 IIKN----PI----LAFFGSLACSPADVDLYAGGFLNAFDTRNASHILVTELLKQEIKRAARSDD 1747

  Fly   543 IFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNL-QD 606
            |.|.|:..::.:....|..|..||.:||||||..||..|:..|||  |:|..|.....:.:| :.
Yeast  1748 ILRRNSCATRALSLYTRSRGNKYLIKTLRPVLQGIVDNKESFEID--KMKPGSENSEKMLDLFEK 1810

  Fly   607 YVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLF 671
            |:.|:.:|||.|.|..|..|..|...:...|..:||   |..|..|..|:||||..||::.|   
Yeast  1811 YMTRLIDAITSSIDDFPIELVDICKTIYNAASVNFP---EYAYIAVGSFVFLRFIGPALVSP--- 1869

  Fly   672 DLTTERL----DAQTSRTLTLISKTIQSLGN----------LVSSRSSQQTCKEEFTVELYKKFC 722
              .:|.:    .|...:....::|.||||.|          |||        ||||.     |.|
Yeast  1870 --DSENIIIVTHAHDRKPFITLAKVIQSLANGRENIFKKDILVS--------KEEFL-----KTC 1919

  Fly   723 TEQHVDAVKHFL-EVISTPSH---ASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQ 783
            :    |.:.:|| |:...|::   .:....|.        |:......:.|:          |..
Yeast  1920 S----DKIFNFLSELCKIPTNNFTVNVREDPT--------PISFDYSFLHKF----------FYL 1962

  Fly   784 RHFRLTTHSLSYAKSKGK-------------------QPICDIPLQEIASVEQLKDK-----SFK 824
            ..|.:....::.:|..|:                   ||..:|..:....|.:.::|     .|.
Yeast  1963 NEFTIRKEIINESKLPGEFSFLKNTVMLNDKILGVLGQPSMEIKNEIPPFVVENREKYPSLYEFM 2027

  Fly   825 MQNCFK-------------IVHNDRSL------IVQTTNCVEEREWFD-LLHKI--------CLM 861
            .:..||             .||...:|      :|..|||.......| |::|:        |..
Yeast  2028 SRYAFKKVDMKEEEEDNAPFVHEAMTLDGIQIIVVTFTNCEYNNFVMDSLVYKVLQIYARMWCSK 2092

  Fly   862 NSIRMQYFHPSAFVSG----------FYSCC-GRSDENSPGC------KKVLDKTMDYFQMD--- 906
            :.:.:..   :.|..|          |:|.. .::..|..||      |..:|:....:.::   
Yeast  2093 HYVVIDC---TTFYGGKANFQKLTTLFFSLIPEQASSNCMGCYYFNVNKSFMDQWASSYTVENPY 2154

  Fly   907 LVTA-----LDPALDLQRIHTLIMSNMSVLESLLD-PLTYH 941
            |||.     ::...|...|.:|.:|..| ||.|.| .:|.|
Yeast  2155 LVTTIPRCFINSNTDQSLIKSLGLSGRS-LEVLKDVRVTLH 2194

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046
C2B_RasA3 280..462 CDD:175977 34/167 (20%)
RasGAP 449..797 CDD:214617 92/377 (24%)
RasGAP_GAP1_like 473..740 CDD:213330 80/285 (28%)
PH 761..859 CDD:278594 23/149 (15%)
PH_GAP1-like 763..867 CDD:269950 24/155 (15%)
BTK 862..897 CDD:128417 8/51 (16%)
IRA1NP_009698.3 RasGAP_Neurofibromin_like 1679..1995 CDD:213341 88/368 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157343026
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R472
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.870

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