Protein Alignment RasGAP1 and IRA1

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: NP_009698.3
• Gene: IRA1 / 852437
• SGDID: S000000344
• Length: 3092
• Species: Saccharomyces cerevisiae
• Alignment Length: 756
• Identity: 166/756 - (21%)
• Similarity: 271/756 - (35%)
• Gaps: 212/756 - (28%)

  Fly   308 YSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTT---------GSNKSAGSLESSAN 363
            :.|..:..|....:|:  |.:|   :|.|..|::.......|         .|:|...:..|:.:
Yeast  1529 FENLSRPLREMDLQKR--DEDF---LYIDTSIESAKALAYLTHNVPLEIPPSSSKEDWNRSSTVS 1588

  Fly   364 KG--YSIYPVG---GADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQP 423
            .|  ::|...|   .|||.:..||:.|.. ..:::.|.:....|...|      ||.|..:.|
Yeast  1589 FGNHFTILLKGLEKSADLNQFPVSLRHKI-SILNENVIIALTNLSNAN------VNVSLKFTL-- 1644

  Fly   424 RSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADH-VFP-------LATYDDLMNL 480
                               |.|...:.|..|..||:.::...:: |.|       :...||.:..
Yeast  1645 -------------------PMGYSPNKDIRIAFLRVFIDIVTNYPVNPEKHEMDKMLAIDDFLKY 1690

  Fly   481 LLESVDQRPITVSAVSILGELVSGKTEV---AQPLVRLFTHTERIAPIIKALADHEISHLTDPTT 542
            ::::    ||    ::..|.|.....:|   |...:..|........::..|...||........
Yeast  1691 IIKN----PI----LAFFGSLACSPADVDLYAGGFLNAFDTRNASHILVTELLKQEIKRAARSDD 1747

  Fly   543 IFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNL-QD 606
            |.|.|:..::.:....|..|..||.:||||||..||..|:..|||  |:|..|.....:.:| :.
Yeast  1748 ILRRNSCATRALSLYTRSRGNKYLIKTLRPVLQGIVDNKESFEID--KMKPGSENSEKMLDLFEK 1810

  Fly   607 YVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLF 671
            |:.|:.:|||.|.|..|..|..|...:...|..:||   |..|..|..|:||||..||::.|
Yeast  1811 YMTRLIDAITSSIDDFPIELVDICKTIYNAASVNFP---EYAYIAVGSFVFLRFIGPALVSP--- 1869

  Fly   672 DLTTERL----DAQTSRTLTLISKTIQSLGN----------LVSSRSSQQTCKEEFTVELYKKFC 722
              .:|.:    .|...:....::|.||||.|          |||        ||||.     |.|
Yeast  1870 --DSENIIIVTHAHDRKPFITLAKVIQSLANGRENIFKKDILVS--------KEEFL-----KTC 1919

  Fly   723 TEQHVDAVKHFL-EVISTPSH---ASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQ 783
            :    |.:.:|| |:...|::   .:....|.        |:......:.|:          |..
Yeast  1920 S----DKIFNFLSELCKIPTNNFTVNVREDPT--------PISFDYSFLHKF----------FYL 1962

  Fly   784 RHFRLTTHSLSYAKSKGK-------------------QPICDIPLQEIASVEQLKDK-----SFK 824
            ..|.:....::.:|..|:                   ||..:|..:....|.:.::|     .|.
Yeast  1963 NEFTIRKEIINESKLPGEFSFLKNTVMLNDKILGVLGQPSMEIKNEIPPFVVENREKYPSLYEFM 2027

  Fly   825 MQNCFK-------------IVHNDRSL------IVQTTNCVEEREWFD-LLHKI--------CLM 861
            .:..||             .||...:|      :|..|||.......| |::|:        |..
Yeast  2028 SRYAFKKVDMKEEEEDNAPFVHEAMTLDGIQIIVVTFTNCEYNNFVMDSLVYKVLQIYARMWCSK 2092

  Fly   862 NSIRMQYFHPSAFVSG----------FYSCC-GRSDENSPGC------KKVLDKTMDYFQMD--- 906
            :.:.:..   :.|..|          |:|.. .::..|..||      |..:|:....:.::
Yeast  2093 HYVVIDC---TTFYGGKANFQKLTTLFFSLIPEQASSNCMGCYYFNVNKSFMDQWASSYTVENPY 2154

  Fly   907 LVTA-----LDPALDLQRIHTLIMSNMSVLESLLD-PLTYH 941
            |||.     ::...|...|.:|.:|..| ||.|.| .:|.|
Yeast  2155 LVTTIPRCFINSNTDQSLIKSLGLSGRS-LEVLKDVRVTLH 2194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046
		C2B_RasA3	280..462	CDD:175977	34/167 (20%)
		RasGAP_GAP1_like	473..740	CDD:213330	80/285 (28%)
		PH_GAP1-like	763..867	CDD:269950	24/155 (15%)
		BTK	862..897	CDD:128417	8/51 (16%)
IRA1	NP_009698.3	RasGAP_Neurofibromin_like	1679..1995	CDD:213341	88/368 (24%)