DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and RASA2

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	XP_016862457.1	Gene:	RASA2 / 5922	HGNCID:	9872	Length:	872	Species:	Homo sapiens

Alignment Length:	991	Identity:	325/991 - (32%)
Similarity:	499/991 - (50%)	Gaps:	179/991 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 NKMADTREVRIEEQLKVK--IGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERT 93
            :|:......:.:|:||.|  ..|||||.      ........||.:|||.|||||:.||..:|::
Human    46 SKLCRRETSKKKERLKNKKAESEAKNLL------PYLGPHKMRDCFCTINLDQEEVYRTQVVEKS 104

  Fly    94 LTPFFGEEHQFKIPRRFRYLTIYLWDRD-MKQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDS 157
            |:|||.||..|:|||.|:||:.|::|:: :::|..|||:|||:|:|..::.|:.||||:|||.:|
Human   105 LSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNS 169

  Fly   158 EVQGMVNVEVAFTEAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRAS 222
            ||||.|::|:...|
Human   170 EVQGKVHLELKLNE--------------------------------------------------- 183

  Fly   223 AAAASSSSAAMTLKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPA 287
                                               :|....|...||            .:.:.|
Human   184 -----------------------------------LITENGTVCQQL------------VVHIKA 201

  Fly   288 CVDLAKKQG-TCDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGS 351
            |..|....| :|||:...:....:::. .::||.:|||.:|:|:|..||::       :.:::.:
Human   202 CHGLPLINGQSCDPYATVSLVGPSRND-QKKTKVKKKTSNPQFNEIFYFEV-------TRSSSYT 258

  Fly   352 NKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPS 416
            .||...:|..           ..:.:||.:.:|:  :|.:...|||||:::| :|.....: :..
Human   259 RKSQFQVEEE-----------DIEKLEIRIDLWN--NGNLVQDVFLGEIKVP-VNVLRTDS-SHQ 308

  Fly   417 AWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLL 481
            |||.||||.                  .|.:.|....:||||||:.||.|:|.|...|..|..||
Human   309 AWYLLQPRD------------------NGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLL 355

  Fly   482 LESVDQRPITVSAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRG 546
            |:|.|.:||:.||..||.|:...|.:...|||||..|.:::.|...|:|:.::....|..|||||
Human   356 LKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRG 420

  Fly   547 NTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERV 611
            |:|.::.:||.|::.|.|||..||:|:|.:|....|.|||||.|:|:...|:.|..||:.||:::
Human   421 NSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKL 485

  Fly   612 FEAITKSADRCPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTE 676
            |..|.||:..||.|:|.||:.||:.|.:.||::..|:||.||.|:||||||.|::.|..|.|...
Human   486 FNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPH 550

  Fly   677 RLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFL-EVISTP 740
            ..||||.|||||||||||:||:..|...|:.:.||.|..|.:|.|..|.::.|||.|| |:.||.
Human   551 HPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTE 615

  Fly   741 SHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQ-FKQRHFRLTTHSLSYAKSKG-KQP 803
            :..||...         |||.||||.|.|....|.|.|:: ||:|.|.||:..|:|.|..| |..
Human   616 TKESSGTS---------EPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDA 671

  Fly   804 ICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQY 868
            |..||::.|.:||:|::.||..:|.|:::|.::.|.||..||||..||.|:|.::...|..|:.:
Human   672 IYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSF 736

  Fly   869 FHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIH---TLIMSNMSV 930
            :|||.:::|.:.||..:.||:.|||..........|:|    :|...:.:||:   ||.:..:..
Human   737 YHPSVYLNGNWLCCQETGENTLGCKPCTAGVPADIQID----IDEDRETERIYSLFTLSLLKLQK 797

  Fly   931 LESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYK 995
            :|.....:..:|...:......|.::       :.|...|    :||::::.....:|..|..|:
Human   798 MEEACGTIAVYQGPQKEPDDYSNFVI-------EDSVTTF----KTIQQIKSIIEKLDEPHEKYR 851

  Fly   996 QGITRQLKYGSRQAPI 1011
            :..:...||||::.||
Human   852 KKRSSSAKYGSKENPI 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	60/127 (47%)
		C2B_RasA3	280..462	CDD:175977	46/182 (25%)
		RasGAP	449..797	CDD:214617	157/349 (45%)
		RasGAP_GAP1_like	473..740	CDD:213330	122/267 (46%)
		PH	761..859	CDD:278594	43/99 (43%)
		PH_GAP1-like	763..867	CDD:269950	44/105 (42%)
		BTK	862..897	CDD:128417	13/34 (38%)
RASA2	XP_016862457.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144463
Domainoid	1	1.000	124	1.000	Domainoid score	I5543
eggNOG	1	0.900	-	-		E1_KOG2059
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	640	1.000	Inparanoid score	I818
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49607
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0000825
OrthoInspector	1	1.000	-	-		otm41766
orthoMCL	1	0.900	-	-		OOG6_104099
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R472
SonicParanoid	1	1.000	-	-		X2711
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800