DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and rasa4

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	XP_005172052.1	Gene:	rasa4 / 567599	ZFINID:	ZDB-GENE-060526-349	Length:	806	Species:	Danio rerio

Alignment Length:	1005	Identity:	258/1005 - (25%)
Similarity:	418/1005 - (41%)	Gaps:	252/1005 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRR 109
            |.::|.|.|||..::..       |:.|.||.:.:|.|.|.||.||.:||:||:|||:...:|..
Zfish     7 LFIRIVEGKNLPIKDIT-------GSSDPYCIVKIDNEAIIRTATIWKTLSPFWGEEYTVHLPPY 64

  Fly   110 FRYLTIYLWDRD-MKQDKPIGKIAIKREELHMY-NHKDHWFSLRPVDQDSEVQGMVNVEVAFTEA 172
            ||.::.|:.|.| :.:|..|||::|.:|.|... ...|.|.:|..:|.|.||||.::::::.
Zfish    65 FRTVSFYVLDEDSLSRDDVIGKVSITKEVLSAKPQGVDGWMNLTEIDPDEEVQGEIHLQISV--- 126

  Fly   173 QQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKT 237
                 |.:|            ::|.                               ......|:.
Zfish   127 -----LGDG------------DIPR-------------------------------KLCCQVLEA 143

  Fly   238 RAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK--QGTCDP 300
            |                                                   |||||  .|..||
Zfish   144 R---------------------------------------------------DLAKKDRNGASDP 157

  Fly   301 FVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKG 365
            ||  ...|:.|   |..:...||:..|.::|:..|:|    |...|::.
Zfish   158 FV--RVRYNGK---TYESSVVKKSCYPRWNESFEFEL----DEALTDSL---------------- 197

  Fly   366 YSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSS 430
                         :.|.||.  ...:|...|||:| |..:||. |.|:....|:.|.|....||
Zfish   198 -------------LSVEVWD--WDLVSRNDFLGKV-LFNINKL-QSALQEEGWFRLGPDKSKHS- 244

  Fly   431 RSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQR-----PI 490
                              ..:.|:|||||:|....:.|.|.:.|..|..||.:||..:     |
Zfish   245 ------------------EYEGTLGSLRLHLRLRDEVVLPSSHYKPLTELLSQSVGSQLNGNWP- 290

  Fly   491 TVSAVSILGELVSGKT--EVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKM 553
              ..:.::.|..:.::  |||..||:||.....:...:..|...|:...|:|.|:||.|:|.||.
Zfish   291 --DFIMLIDETTTAESRQEVANNLVKLFLGQGLVKEFLDVLFKLELDKTTEPNTLFRSNSLASKS 353

  Fly   554 MDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHN--------------L 604
            |:..::::|:.|||:.|.|::::|..|||..|:||||::.:.|....||.              |
Zfish   354 MESFLKVAGMQYLHRLLGPIINRIFEEKKYVELDPSKVELKEAGCAGLHRQQTESDVIQQSSSLL 418

  Fly   605 QDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHF--PSNREVRYSVVSGFIFLRFFAPAILG 667
            |.|:..:..:|.:||..||.::||:||.|.....|.|  |..|:|::..|:.|:.|||.:|||:.
Zfish   419 QSYLSELLTSILQSASYCPLLICQVFHQLYLRVQERFPDPEYRKVKFIAVTSFLCLRFISPAIMS 483

  Fly   668 PKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTC-KEEFTVELYKKFCTEQHVDAVK 731
            ||||.|..:..||:|||||.|::|.:|::||:    .:...| ||.:.|.|..  ..:|.:..:|
Zfish   484 PKLFHLREKHADARTSRTLLLLAKAVQTIGNM----DTLACCSKEPWMVRLQP--AIQQGITQLK 542

  Fly   732 HFLEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRK--RFGRQFKQRHFRLTTHSLS 794
            .|:..: ...|.|..:......:... ..:.|||.:..:.|..|  .....||:.:..|:..:||
Zfish   543 DFITRL-VNCHESEDLELQTRMSLQC-GTMEKEGFLFLHRTKDKCMPMTSPFKKYYVTLSKDTLS 605

  Fly   795 YAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRS-----LIVQTTNCVEEREWFDL 854
            |:::...:....|.|.:|.:||::::|.|...|..:|:.::.|     |.:...:..|...|...
Zfish   606 YSRTLHSKKSSSISLPKIRAVEKVEEKCFGSANVMQIISSEDSGQQETLYLDCKSVNELNHWLSA 670

  Fly   855 LHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQM-DLVTALDPALDLQ 918
            |.|.|..|:..|..|||..:.:..:|||.:.:::.|||    |||.....: :....|||.|:.|
Zfish   671 LRKACSHNTNTMSCFHPGIYKADRWSCCHQKEKSDPGC----DKTRHGVTLQEWYDPLDPDLEAQ 731

  Fly   919 RIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDL----------QKHSPQAFAEF 973
            .|                    :|.||..||...:....|....          ||.| ...::.
Zfish   732 LI--------------------YQHLSSVQHAMRDKYYKLREQQGIQEADSGRDQKKS-DGVSQL 775

  Fly   974 KRTIEKLREKAYAIDRDHRDYKQGITRQLK 1003
            ...::.|.|...|::.:.|...:.:..:|:
Zfish   776 FDILQDLHEAHTAVEEEERSKNKNVFLELQ 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	46/125 (37%)
		C2B_RasA3	280..462	CDD:175977	45/183 (25%)
		RasGAP	449..797	CDD:214617	118/373 (32%)
		RasGAP_GAP1_like	473..740	CDD:213330	96/290 (33%)
		PH	761..859	CDD:278594	26/104 (25%)
		PH_GAP1-like	763..867	CDD:269950	28/110 (25%)
		BTK	862..897	CDD:128417	11/34 (32%)
rasa4	XP_005172052.1	BTK	685..712	CDD:279161	11/30 (37%)
		C2A_Rasal1_RasA4	6..126	CDD:176018	46/125 (37%)
		C2B_RasA1_RasA4	135..258	CDD:175991	47/234 (20%)
		RasGAP	247..607	CDD:214617	117/370 (32%)
		RasGAP	266..552	CDD:295371	97/295 (33%)
		PH_CAPRI	545..684	CDD:241523	31/140 (22%)
		PH	571..676	CDD:278594	26/104 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577568
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0000825
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850