Protein Alignment RasGAP1 and rasal1

DIOPT Version :9

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: XP_017948045.1
• Gene: rasal1 / 493411
• XenbaseID: XB-GENE-942936
• Length: 831
• Species: Xenopus tropicalis
• Alignment Length: 1022
• Identity: 264/1022 - (25%)
• Similarity: 422/1022 - (41%)
• Gaps: 279/1022 - (27%)

  Fly    45 LKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRR 109
            |..::.|.|||.:::.:       ||.|.||.:.:|.|.:.||.|:.|.|.||:|||....:|..
 Frog     7 LYFRLVEGKNLPAKDVS-------GTSDPYCIVKVDNEVVARTATVWRDLNPFWGEEFTLHLPLG 64

  Fly   110 FRYLTIYLWDRD-MKQDKPIGKIAIKREELHMYNHK---DHWFSLRPVDQDSEVQGMVNVEVAFT 170
            |..|:.|:.|.| :..|..||||::.:|  .:.:|.   |.|.:|..||.|.||||.:.:|:...
 Frog    65 FHTLSFYVMDEDTIGHDDVIGKISLTKE--FIASHPRGIDSWVNLGRVDPDEEVQGEIYLELHIM 127

  Fly   171 EAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTL 235
            :.|...:|                   |.|                                 .|
 Frog   128 QDQYRSTL-------------------HCH---------------------------------VL 140

  Fly   236 KTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK--QGTC 298
            :.|                                                   |||.:  .||.
 Frog   141 EAR---------------------------------------------------DLAPRDISGTS 154

  Fly   299 DPFV--VCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESS 361
            ||||  .|       :..|..|...|:|..|.::|.:.|||.
 Frog   155 DPFVRIFC-------NNQTLETSVIKRTRFPRWNEVLEFDLR----------------------- 189

  Fly   362 ANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSM 426
                 .|..:..:|.: |.:.||.......:|  |||.|..|:....:..||  ::|:.|.|...
 Frog   190 -----GIEELDPSDQM-ISIEVWDWDMVGKND--FLGRVWFPIEPLHKSPAV--TSWFRLLPFGN 244

  Fly   427 THSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESV---DQR 488
            |.....                   ..:||||:.::.:.:.:.|...|..|:.||:|||   ||.
 Frog   245 TDEENG-------------------GKLGSLRIKVSLSEERILPSLYYQTLIQLLVESVQSPDQG 290

  Fly   489 PITVSAVSILGELVSGKT--EVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVS 551
            ...:  :::|.|:.|.::  |||..||::|.........:..|...|:....||.|:||.|:|.|
 Frog   291 DCNL--LALLEEICSAESRQEVAVKLVKIFLGQGLAVTFLDKLNQREVKRTVDPNTLFRSNSLAS 353

  Fly   552 KMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKI--------------KDRSAVDTNLH 602
            |.|::.|::.|:.:||:.|||::|:|..||:..|:||.||              .:...::::|.
 Frog   354 KSMEQYMKIVGMPFLHEILRPIISKIFEEKRYIELDPCKIDLNRSRRISFKGSMSEHHILESSLE 418

  Fly   603 NLQDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPS--NREVRYSVVSGFIFLRFFAPAI 665
            .|:.|:..:.:||.:|.::||..:...|..|.:...|.||.  .::|:|:.:|||:|||||||||
 Frog   419 TLRGYLSDIIDAILRSVEQCPSGMRLCFKQLHKRVEEQFPGAVYQDVKYAAISGFLFLRFFAPAI 483

  Fly   666 LGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQT--CKEEFTVELYKKFCTEQHVD 728
            |.||||.|.....|.:|:|||.||:|.:||:|||     .||.  .||::...|:.  ..:|.|.
 Frog   484 LTPKLFHLREHHADPRTARTLLLIAKAVQSIGNL-----GQQLGYGKEQWMAPLHP--FIQQSVG 541

  Fly   729 AVKHFLE-VISTPSHASSSVHPAAAAATPLE----------------PVLLKEGLMTKYPTSRK- 775
            .::.||: :|...|.....:.....|...|:                .|.:|||.:.|    ||
 Frog   542 RLRDFLDRLIDMESETVEQIEKMNKAHKGLQRSFSKCGQISRTLFHPSVTIKEGFLHK----RKA 602

  Fly   776 -------RFGRQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVH 833
                   ||  .||:|:|.|::.:|||:||...|....||:..|.:||::.:.:|:..|..:|:.
 Frog   603 EAVNLVTRF--TFKKRYFWLSSQTLSYSKSPDWQVRSSIPVHRICAVERVDENAFQHPNMMQIIS 665

  Fly   834 NDRS------LIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGC 892
            .|..      :.:|..|..|..:|...|.|:.|.|...:..:||.|:.:..::||.::|....||
 Frog   666 QDSETQGGHIMYIQCKNVNELNQWLSALRKVSLCNQRLLPTYHPGAYRNAHWTCCLQTDRTVRGC 730

  Fly   893 KKV-LDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVL-ESLLDPLTYHQSLSQTQHQQHNPL 955
            .:. |..|:.    |....|||..:.|.::..::.:..|| :..|:                |.|
 Frog   731 SRTHLAVTLG----DWSDPLDPDAEAQVLYRHLLLSKDVLRDKYLE----------------NSL 775

  Fly   956 VPLATDLQKHSPQAFAEFKRT---------IEKLREKAYAIDRDHRD 993
            .....:.:.||.:.||....:         ||.|.....|.::..|:
 Frog   776 NAEKAECKGHSEKGFAGMAVSSPARCLLFAIEDLERAHQAFEKRERE 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	46/127 (36%)
		C2B_RasA3	280..462	CDD:175977	40/185 (22%)
		RasGAP	449..797	CDD:214617	127/395 (32%)
		RasGAP_GAP1_like	473..740	CDD:213330	102/290 (35%)
		PH	761..859	CDD:278594	34/111 (31%)
		PH_GAP1-like	763..867	CDD:269950	36/117 (31%)
		BTK	862..897	CDD:128417	9/35 (26%)
rasal1	XP_017948045.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0000825
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020