DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and Rasal1

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	NP_001101805.1	Gene:	Rasal1 / 360814	RGDID:	1311820	Length:	801	Species:	Rattus norvegicus

Alignment Length:	990	Identity:	270/990 - (27%)
Similarity:	414/990 - (41%)	Gaps:	256/990 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRR 109
            |.:::.|.:.|.:::.:       |:.|.||.:.:|.|.:.||.||.|:|:||:|||:...:|..
  Rat     7 LSIRVVEGRALPAKDVS-------GSSDPYCLVKVDDEVVARTATIWRSLSPFWGEEYTVHLPLD 64

  Fly   110 FRYLTIYLWDRD-MKQDKPIGKIAIKREELHMYNHK-DHWFSLRPVDQDSEVQGMVNVEVAFTEA 172
            |.:|..|:.|.| :..|..||||::.:|.:...... |.|.:|..||.|.||||.|.:.|...|.
  Rat    65 FHHLAFYVLDEDTVGHDDIIGKISLSKEAITADPRGIDSWINLSRVDPDEEVQGEVCLAVKLLED 129

  Fly   173 QQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKT 237
            .:.:.|                        |.|:...:
  Rat   130 ARGRCL------------------------RCHVRQAR--------------------------- 143

  Fly   238 RAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK--QGTCDP 300
                                                                |||.:  .||.||
  Rat   144 ----------------------------------------------------DLAPRDISGTSDP 156

  Fly   301 FVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKG 365
            |  ....:.::   :..|...|||..|.:||.    |.:....|:|:
  Rat   157 F--ARVFWGSR---SLETSTIKKTRFPHWDEV----LELREAPGTTS------------------ 194

  Fly   366 YSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSS 430
                        .:.|.:|.......:|  |||.|.   ...|..|...|:.|:.|.|......|
  Rat   195 ------------PLRVELWDWDMVGKND--FLGMVE---FTPQTLQQKPPNGWFRLLPFPRAEDS 242

  Fly   431 RSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPI---TV 492
                                ..::|:|||.:..|.|.|.|...|..||.|||||| |.|.   |.
  Rat   243 --------------------GGSLGALRLKVRLTEDRVLPSQYYQPLMELLLESV-QGPAEEDTT 286

  Fly   493 SAVSILGELVSG--KTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMD 555
            |.:::|.||.||  :.::|..||:||.......|.:..|...|::...||.|:||.|:|.||.|:
  Rat   287 SPLALLEELASGDCRQDLATKLVKLFLGRGLAGPFLDYLTRREVARTNDPNTLFRSNSLASKSME 351

  Fly   556 EAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKI--------------KDRSAVDTNLHNLQD 606
            :.|:|.|:.|||:.||||:|::..|||..|:||||:              .:....:|:|..|..
  Rat   352 QFMKLVGMRYLHEVLRPVISRVFEEKKYMELDPSKMDLNRSRRISFKGTPTEEQVRETSLGLLTG 416

  Fly   607 YVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFP--SNREVRYSVVSGFIFLRFFAPAILGPK 669
            |:..|.:||..||.|||..|...|..|::|..:.||  .:::|:|...|||:||||||||||.||
  Rat   417 YLGSVVDAIVSSAGRCPLALRLAFKQLQQCVEKRFPGMEHQDVKYLATSGFLFLRFFAPAILTPK 481

  Fly   670 LFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQ--TCKEEFTVELYKKFCTEQHVDAVKH 732
            ||||.....|.||||:|.|::|.:||:|||     .||  ..||::...|:....  |.:..|:.
  Rat   482 LFDLRDHHADPQTSRSLLLLAKAVQSIGNL-----GQQLGQGKEQWLAPLHPFLL--QSISRVRD 539

  Fly   733 FLEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTK---YPTS-RKRFGRQFKQRHFRLTTHSL 793
            ||:.:........:.....|...|  ..:::||.:.|   .|.| ..||.  ||:|:|||:...|
  Rat   540 FLDQLVDVDGDEEAGGSTCALVQP--STIVREGFLLKRKEEPASLATRFA--FKKRYFRLSGRDL 600

  Fly   794 SYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHND-----RSLIVQTTNCVEEREWFD 853
            ||:|:...|....|||..|.:||::.:.:|::.:..::|..|     .:..:|..|..:..:|..
  Rat   601 SYSKTPEWQVHSSIPLSCIRAVERVDEGAFQLPHVMQVVTQDGTGASHTTYLQCKNVNDLNQWLS 665

  Fly   854 LLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDK-TMDYFQMDLVTALDPALDL 917
            .|.|....|..::...||.||.||.::||.:::.::.||.:.... |:.    |....|||..:.
  Rat   666 ALRKASAPNPGKLAACHPGAFRSGRWTCCLQAERSAVGCSRTHSAVTLG----DWSDPLDPDAEA 726

  Fly   918 QRIHTLIMSNMSVL------ESLLD----------------PLTYHQSLSQTQHQQHNPLVPLAT 960
            |.::..::.....|      :|.||                |..  :.|:| |.:....|:.:..
  Rat   727 QMVYRQLLLGRDQLRLKLLEDSSLDTAPDVDPGKDSSAVDGPCA--EVLAQ-QREATTRLLQVLE 788

  Fly   961 DLQKHSPQAFAEFKR 975
            ||:    ||..||::
  Rat   789 DLE----QAHEEFQK 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	44/125 (35%)
		C2B_RasA3	280..462	CDD:175977	36/183 (20%)
		RasGAP	449..797	CDD:214617	142/374 (38%)
		RasGAP_GAP1_like	473..740	CDD:213330	116/289 (40%)
		PH	761..859	CDD:278594	32/106 (30%)
		PH_GAP1-like	763..867	CDD:269950	33/112 (29%)
		BTK	862..897	CDD:128417	11/34 (32%)
Rasal1	NP_001101805.1	C2	6..126	CDD:301316	44/125 (35%)
		C2	134..254	CDD:301316	39/286 (14%)
		RasGAP	242..604	CDD:214617	143/393 (36%)
		RasGAP_RASAL	262..548	CDD:213337	117/293 (40%)
		PH-like	552..689	CDD:302622	39/140 (28%)
		PH	566..672	CDD:278594	32/107 (30%)
		BTK	681..708	CDD:279161	10/26 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0000825
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850