DRSC/TRiP Functional Genomics Resources

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Protein Alignment RasGAP1 and raskol

DIOPT Version :9

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:NP_001285388.1 Gene:raskol / 32754 FlyBaseID:FBgn0261570 Length:2016 Species:Drosophila melanogaster


Alignment Length:1139 Identity:244/1139 - (21%)
Similarity:407/1139 - (35%) Gaps:334/1139 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 WDRDMKQDKPIGKIAIKREELHMYNHKDHW-------FSLRPVDQDSEVQGMVNVEVAFTEAQQT 175
            |.:...|  |.....:..:||:.|...|..       |.:|.:.........:..:::.|...:|
  Fly   507 WGKHFYQ--PYDVCPLSLDELNCYFQADQCEKLICERFKIRDLAIHMASASAIGADLSVTTENET 569

  Fly   176 QSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAA 240
            .:.::. |.|     ||.:.   |:::............|.:.|..:...|:|         |..
  Fly   570 TATADD-DAG-----HHSDT---SYEKACRRGSAPTTPILGSKQHQTEHNATS---------RFT 616

  Fly   241 GLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFV-VC 304
            ..|....:|..:|:....:..|...|..|...:||...:. :..|.:.:||     :|...| |.
  Fly   617 NFFSKKSNPLKRTKSVTKLERTKRGSGGLRGSRSHESLLS-SHAVMSTIDL-----SCTGAVGVA 675

  Fly   305 TAHYS---NKH--QV-----------------------------------TRRTKQ-------RK 322
            ..|.|   .:|  ||                                   ||||..       ..
  Fly   676 PVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEA 740

  Fly   323 KTVDPEFDEAMYF-DLHIDADAGSTNTTGSNKSAGSLESSA---NKGYSIYPVGGADLVE---IV 380
            |.:.|   :..|| :|.:|       .|...:::..|::..   .:.:. :|    |:.|   |.
  Fly   741 KNLPP---KKRYFCELQLD-------KTLYGRTSVKLQTDLLFWGEHFD-FP----DIPEINVIT 790

  Fly   381 VSVWHDAHGAMS-DKV-FLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATP 443
            |:|:.:...... ||. |:|.|::|:.:...:  :....||   |.....:..||..|    :..
  Fly   791 VNVFREVDKKKKRDKYQFVGSVKIPVHDVTSR--LPCEQWY---PILSDKAGDSLGRT----SGG 846

  Fly   444 PGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVSGKTEV 508
            .|:.......:.:||:...:.:..:.|:..|.:.:..|.|  :.:.:..:...::|  |..|.::
  Fly   847 GGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKE--NYKRVCETLEPVIG--VKAKEDI 907

  Fly   509 AQPLVRLFTHTERIA-PIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRP 572
            .|.|| |..|.:.:| ..:..:...::..:.|....||||:|.:|.|:..::|:|..||..||..
  Fly   908 GQALV-LLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSA 971

  Fly   573 VLSQIVAEKKPCEIDPSKIKDRSA--VDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLRE 635
            .:::::..::.||:||:|....||  :......|:..|...::.|.:|....|..|...|...||
  Fly   972 PINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRE 1036

  Fly   636 CAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLV 700
            ...:  ...:::..:::|..|||||..||||.|.||::|:|...|:.:|.|||::||:|:|.|..
  Fly  1037 RLQQ--LGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANFT 1099

  Fly   701 SSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPAAAAATPLEPVLLKEG 765
            ..:.     ||.| :|....| .||....::.|||:|||...     |||.      :.:|...|
  Fly  1100 RFQG-----KENF-MEFLNDF-LEQEAARMQQFLEIISTRPE-----HPAP------DSILDWAG 1146

  Fly   766 LMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAK-SKGKQPICDIPLQEIASVEQLKDKSFKMQNCF 829
            .:.:        |:|....|..|   |.|.|| .:.:|...| |||.|                 
  Fly  1147 YIDQ--------GKQLSILHSLL---SESLAKLPEARQHELD-PLQHI----------------- 1182

  Fly   830 KIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFV---SGFYSCCGRSDEN-SP 890
                                     |.:|.......|....|..::   |..:|....:.|| :|
  Fly  1183 -------------------------LDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNP 1222

  Fly   891 G---------CKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLSQ 946
            |         .:::|.:     |..|.         |..|.::...:|....::..:....||.:
  Fly  1223 GSSGSHAGSNSEQLLPQ-----QSQLA---------QPQHAIVSKPLSAERGIMRGVLTPNSLEK 1273

  Fly   947 TQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAPI 1011
            ...:.::|.|                                                       
  Fly  1274 NIFRYNDPTV------------------------------------------------------- 1283

  Fly  1012 GDDNYWHMMRAAGQLNQQHHQQQQHQQQQQQQQQQQLQQ--FQPQP----VLPQMQNVRA----- 1065
                       .|.|.||  ||||.||||||||.|||||  .|.||    .|..:.|.:.     
  Fly  1284 -----------NGLLQQQ--QQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGN 1335

  Fly  1066 -YPYQP------------ATSNMN---AYCLHNMQYQQQRLPFHQQQQQHHQQLQQQQSQFQPLR 1114
             |...|            |:|::|   :..||.          |||...|.|||........|..
  Fly  1336 QYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHG----------HQQHAHHPQQLHPHHCPPAPQT 1390

  Fly  1115 S-----HQLQRHNNNLNNNNCGNGSSSSPSSTTS 1143
            |     .::.|.|....::|..:..:|:||||.|
  Fly  1391 SASSTMERMDRMNYPYMSHNGNDYETSTPSSTRS 1424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046 9/57 (16%)
C2B_RasA3 280..462 CDD:175977 44/238 (18%)
RasGAP 449..797 CDD:214617 94/350 (27%)
RasGAP_GAP1_like 473..740 CDD:213330 79/269 (29%)
PH 761..859 CDD:278594 17/98 (17%)
PH_GAP1-like 763..867 CDD:269950 17/104 (16%)
BTK 862..897 CDD:128417 8/47 (17%)
raskolNP_001285388.1 PH_RasSynGAP-like 615..729 CDD:270082 21/119 (18%)
PH <656..720 CDD:278594 11/69 (16%)
C2_SynGAP_like 721..874 CDD:175980 33/176 (19%)
RasGAP 856..1185 CDD:214617 103/407 (25%)
RasGAP_DAB2IP 865..1192 CDD:213338 102/405 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45444790
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46640
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10194
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.940

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