DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RasGAP1 and vap

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	176/780 - (22%)
Similarity:	300/780 - (38%)	Gaps:	193/780 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 FFGEEHQ---FKIPRR-FRYLTIYLWDRDMK-QDKPIGKIAIKREEL---HMYNHKDHWFSLRPV 153
            ||...:|   |:|.:: .|||   :..|..: .|..|.:  .::|::   |..||        ||
  Fly   290 FFHINNQIQRFRIEKKGVRYL---MGGRTFECLDAVINR--YRKEQIVEGHSLNH--------PV 341

  Fly   154 DQDSEVQGMVNVEVAFTEAQQTQSLSEGI---------DLGQHTLRHHQNLPHHSHQQR------ 203
                 |.|   ::..|.:....:..:|.|         .:|   |:..:.:.||.|..:
  Fly   342 -----VNG---IQPEFNQQYVVEKAAEKIYATLRECRDQIG---LKKIKGIKHHGHLNKKSDKTT 395

  Fly   204 -------AHLNDYKENSEL---SNIQRASAAAASSSSAA---------------MTLKTRAAGLF 243
                   |.:||..| ::|   .|.::.........|.|               ..:..||....
  Fly   396 KWKQLYFALINDGSE-TQLCFYDNPKKTKPKGLIDLSCAYLYQCHDSLWERPYCFQIVERALPCL 459

  Fly   244 GHVHH--PPSQTQHFPIINTTSTSSD-QLSN-WKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVC 304
            ..|.:  .|||..:...||:.....| |||. .|...|     ::...|::|...:....||.:.
  Fly   460 ATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKKVSR-----LRELRCLNLHVLEAHRLPFKLV 519

  Fly   305 TAHYS--NKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKGYS 367
            ...|.  :.:||.....:.|...:|.::|....| .:..|..|...|        |.|...:|..
  Fly   520 PHPYCSISLNQVKVGKTRVKIAPEPVWEEEFVLD-DVPPDVVSLTIT--------LISRGKRGKD 575

  Fly   368 IYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRS 432
                  :::.|:.:.:                  ..:.|.||.:     .||.|
  Fly   576 ------SEVAELTIDL------------------SSLKNGQETE-----GWYQL----------- 600

  Fly   433 LNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSI 497
                  :..||.|       ..|||||.:.|..|.:.|...|..|..|||||      .:.||..
  Fly   601 ------TGMTPMG-------EWGSLRLRMRYLDDLIMPCEEYSPLQQLLLES------ELYAVKA 646

  Fly   498 LGELV-SGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLS 561
            |.||. :.:..:|..|:|:|...:|...:|:.|...|::...:.||:|||.:|.:.:||..||..
  Fly   647 LAELCHNDRVPLATALLRVFRQEKRETELIRMLCQAEVTRENETTTLFRGASLATTLMDLYMRTE 711

  Fly   562 GLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVL 626
            ...:|...:...:.:|:..|:..|::|:|:.......||...|...::.|.::|..|.|.||:.:
  Fly   712 CSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDACTNAEFLLQILDLVTQSIFTSPDACPRNV 776

  Fly   627 CQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISK 691
            ..|...|::.....:|:.|.||..|||||||||...||:|.|:.|.|.:|......:|:|.:::|
  Fly   777 RFICSCLQKAVMAKWPTERLVRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAK 841

  Fly   692 TIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPAAAAATP 756
            .:|:|.||:           ||..:       ||:::.|..|  ::.........:...::...|
  Fly   842 CLQNLANLI-----------EFGGK-------EQYMEVVNPF--ILKNKERMIVFLDQLSSVNDP 886

  Fly   757 LEPVLLKEGLMTKYPT--SRKRFGRQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIASVEQLK 819
            .:|:    |:..:..|  :.:..||:....|....:||..              |.|::::..:|
  Fly   887 NQPL----GMFVEQSTNLNSQDTGRELATLHHICVSHSQE--------------LHELSNILSIK 933

Fly 820 819
Fly 934 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	19/79 (24%)
		C2B_RasA3	280..462	CDD:175977	32/183 (17%)
		RasGAP	449..797	CDD:214617	97/350 (28%)
		RasGAP_GAP1_like	473..740	CDD:213330	80/267 (30%)
		PH	761..859	CDD:278594	10/61 (16%)
		PH_GAP1-like	763..867	CDD:269950	10/59 (17%)
		BTK	862..897	CDD:128417
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217	11/40 (28%)
		PH_RASA1	379..484	CDD:270080	19/105 (18%)
		C2_Ras_p21A1	499..622	CDD:176045	33/184 (18%)
		RasGAP	620..954	CDD:413381	94/358 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444792
Domainoid	1	1.000	51	1.000	Domainoid score	I2876
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46640
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10194
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950