DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and Rasal3

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	XP_006524475.1	Gene:	Rasal3 / 320484	MGIID:	2444128	Length:	1065	Species:	Mus musculus

Alignment Length:	985	Identity:	208/985 - (21%)
Similarity:	320/985 - (32%)	Gaps:	275/985 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 DLAKKQGTCDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKS 354
            |..:..|..:|....:....|..::.:|.|::|:....       ...:...| |..:..||.:|
Mouse   227 DAVRTPGKTEPEAAGSNQVHNVRKLLKRLKEKKRAKSE-------LGAYTPRD-GPPSALGSRES 283

  Fly   355 AGS---LESSANKGYSIYPV----------------GGADLVEIVVSVWHDAHGAMSDKVFLGEV 400
            ..:   |:..|.:...::|:                ||        |:......:.....::.::
Mouse   284 LATLSELDLGAERDVRVWPLHPSLLGEPYCFQVTWAGG--------SLCFSCRSSAERDRWIEDL 340

  Fly   401 R---LPMLNKQEQQAVNPSAWYYLQ---PRSMTHSSRS---------LNATPRSC---------- 440
            |   .|..:..|:|.:..:.|.:..   ||:.....|:         ....||:.
Mouse   341 RRQFQPSQDNVERQEMWLTVWVHEAKGLPRATVPGVRAELWLDGALLARTAPRAGPGQLFWAERF 405

  Fly   441 ---ATPPGTRLSV--------DSTIGS--------------------------------LRLNLN 462
               |.||..|||:        .:|:|.                                ||..:.
Mouse   406 HFEALPPARRLSLRLRSAGPAGATVGRVVLELDEVSIPRAPAAGLERWFPVLGAPAGAVLRARIR 470

  Fly   463 YTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGEL-----VSGKTEVAQPLVRLFTHTERI 522
            .....|.|...|.:|...|         |.....:.|.|     ...|.|:|..:||:...|.|.
Mouse   471 VRCLRVLPSERYKELAEFL---------TFHYARLCGALEPALSAQAKEELAAAMVRVLRATGRA 526

  Fly   523 APIIKALADHEISHLTD-PTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEI 586
            ..::..|...|::.... ...:||.|||.:|.:||.|:|....||..||..|:..:.|..:.||:
Mouse   527 QALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQEYLQDTLGQVVRCLCASTEDCEV 591

  Fly   587 DPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLRE-CAGEHFPSNREVRYS 650
            ||||. ....:..:...|:|..|.|||.|..|.:..|..|..:|...|| |...   .:..:...
Mouse   592 DPSKC-PTPELPKHQARLRDSCEEVFENIIHSYNCFPAELGSVFSSWREACKAR---GSEALGPR 652

  Fly   651 VVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTV 715
            :|...:|||...||||.|.||.|..|......:||||||:|.||:|.|          |......
Mouse   653 LVCASLFLRLLCPAILAPSLFGLAPEHPAPGPARTLTLIAKVIQNLAN----------CAPFGEK 707

  Fly   716 ELYKKFCT---EQHVDAVKHFLEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRF 777
            |.|..|..   |.|..|::|||:.::|          ..|..||           :.|..|.. .
Mouse   708 EAYMAFMNSFLEDHGPAMQHFLDQVAT----------VDADTTP-----------SGYQGSGD-L 750

  Fly   778 GRQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFK-MQNCFKIVHNDRSLIVQ 841
            ..|....|.:|                |.|    .|.::|....|.: :....:.:...|.:.|.
Mouse   751 ALQLAVLHVQL----------------CTI----FAELDQKTQDSLEPLPTILRAIEEGRPVPVS 795

  Fly   842 TTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMD 906
            ..                 |...|:.....|:|.||          ..||
Mouse   796 VP-----------------MRLPRISTQVQSSFFSG----------EKPG--------------- 818

  Fly   907 LVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFA 971
               .|.|. ||.: ||.::|....|.|.....::.......:..|..|...|.|       |:..
Mouse   819 ---FLAPR-DLPK-HTPLISKSQSLRSFQGAGSWASRRPDEERPQRRPRPVLRT-------QSVP 871

  Fly   972 EFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAPIGDDNYWHMMRAAGQLNQQHHQQQQH 1036
            ..:.|              ||....|...:.|...|..|......|  .||:..|.::.....|.
Mouse   872 ARRPT--------------HRRPSAGSKPRPKGSLRMGPAPCGRAW--TRASASLPRKPSVPWQR 920

  Fly  1037 QQQQQQQQQQQLQQFQPQPVLPQMQ-NVRAY-PYQPATSNMNAYCLHNMQYQQQRLPFHQQQQQH 1099
            |..|...:.|.....:|...|.::| .|..: ..|.|.|.:    :.::..|.|.|   ::||:|
Mouse   921 QMDQPGDRYQTTGTHRPVGKLAEIQCEVAIFREAQKALSLL----VESLSTQVQAL---KEQQEH 978

  Fly  1100 HQ-QLQQQQSQF------------QPLR-SHQLQRHNNNLNNNNCGNGSSSSPSSTTSSVVAAPP 1150
            .: |||...|:.            .|.. ||:|:.....|....|   |......:..|:.....
Mouse   979 FRCQLQDLYSRLGAGISKLDSKGGLPSNGSHRLKSLEQRLTEMEC---SQDQLRDSLQSLQLLSK 1040

  Fly  1151 STTSSSQPAP 1160
            :..|.|||.|
Mouse  1041 TPGSRSQPLP 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046
		C2B_RasA3	280..462	CDD:175977	38/258 (15%)
		RasGAP	449..797	CDD:214617	101/397 (25%)
		RasGAP_GAP1_like	473..740	CDD:213330	85/276 (31%)
		PH	761..859	CDD:278594	12/98 (12%)
		PH_GAP1-like	763..867	CDD:269950	14/104 (13%)
		BTK	862..897	CDD:128417	7/34 (21%)
Rasal3	XP_006524475.1	PH-like	227..372	CDD:388408	25/160 (16%)
		C2	346..478	CDD:387358	20/131 (15%)
		RasGAP_DAB2IP	470..793	CDD:213338	102/387 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840