Protein Alignment RasGAP1 and Rasa3

DIOPT Version :9

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: NP_113762.1
• Gene: Rasa3 / 29372
• RGDID: 69365
• Length: 834
• Species: Rattus norvegicus
• Alignment Length: 994
• Identity: 358/994 - (36%)
• Similarity: 534/994 - (53%)
• Gaps: 176/994 - (17%)

  Fly    39 VRIEEQLKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQ 103
            :|:.:.:::||||||||.|....|.      .||.|||:.|||||:.||..:|::|.||:||:..
  Rat     8 LRVFQSVRIKIGEAKNLPSYPGPNK------MRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFY 66

  Fly   104 FKIPRRFRYLTIYLWDRDM-KQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEV 167
            .:|||.||:|:.|::|||: ::|..|||:||::|:|..|:::|.||.|:.||.||||||.|::|:
  Rat    67 CEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQRYHNRDTWFQLQHVDADSEVQGKVHLEL 131

  Fly   168 AFTEAQQTQSLSEGI-DLGQ--HTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSS 229
                     .|||.| |.|.  |.|
  Rat   132 ---------RLSEVITDTGVVCHKL---------------------------------------- 147

  Fly   230 SAAMTLKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK 294
                     ||.:|        :.|..||:|
  Rat   148 ---------AARIF--------ECQGLPIVN---------------------------------- 161

  Fly   295 QGTCDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLE 359
             |.|||:...|.....:.: .::||.:|||.:|:|||..||::       :...:.|.||....|
  Rat   162 -GQCDPYATVTLAGPFRSE-AKKTKVKKKTNNPQFDEVFYFEV-------TRPCSYSKKSHFDFE 217

  Fly   360 SSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPR 424
            ..           ..|.:||.|.:|:.::....|: ||||:|:|:  ...:.|.:..|||:||||
  Rat   218 EE-----------DVDKLEIRVDLWNASNLKFGDE-FLGELRIPL--HVLRYASSYEAWYFLQPR 268

  Fly   425 SMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRP 489
            .  :.|:|:.                ...:||||||:.||.||||....|..|.:|||:|.|..|
  Rat   269 D--NGSKSVK----------------PDDLGSLRLNVVYTEDHVFSSEYYSPLRDLLLKSADVEP 315

  Fly   490 ITVSAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMM 554
            ::.||..||||:...|.|.|.|||||..|..|:.|.|.|:|..|:....||.||||||:|.||.:
  Rat   316 VSASAAHILGEVCRDKQEAAIPLVRLLLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLTSKCI 380

  Fly   555 DEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSA 619
            ||.|:|:|:||||.||:|.:.:|....|.|||||.|:||...::.|:.:|:.||:|:|..||||.
  Rat   381 DETMKLAGMHYLHVTLKPTIEEICQSHKSCEIDPVKLKDGENLENNMESLRQYVDRIFSVITKSG 445

  Fly   620 DRCPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSR 684
            ..||.|:|.||..|||.|.:.|..:.:|||:.||.||||||||||||.|.||.||....|.||||
  Rat   446 VSCPTVMCDIFFSLREAAAKRFQDDLDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSR 510

  Fly   685 TLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHP 749
            ||||||||||:||:|  |:|...:.||.:....|:.|..:::.||||:||::||    :|....|
  Rat   511 TLTLISKTIQTLGSL--SKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLIS----SSGRRDP 569

  Fly   750 AAAAATPLEPVLLKEGLMTKYPTSRKRFG-RQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIA 813
            .:..    :|:|||||.|.|....||||| :.||:|.||||.|..:|.||||.||:|:||::.|.
  Rat   570 KSIE----QPILLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKGDQPLCNIPIENIL 630

  Fly   814 SVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGF 878
            :||:|:::||:|:|.|:::..:|:|.:|..||||.::|.|:|.|:...|..|:..|||||:::|.
  Rat   631 AVERLEEESFRMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVFHPSAYLNGH 695

  Fly   879 YSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQS 943
            :.||..|.:.:.||...........|:|    :|...:.:||::|....|..||.:.:.......
  Rat   696 WLCCRASSDTAIGCTPCTGGLPANIQLD----IDGDRETERIYSLFNLYMGKLEKMQEACGSKSV 756

  Fly   944 LSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQ 1008
            ....:.::::..:       ...||   |..||::::......::::|..|::...::.:|||::
  Rat   757 YDGPEQEEYSTFI-------IDDPQ---ETYRTLKQVIAGVGTLEQEHAQYRRNKFKKTRYGSQE 811

  Fly  1009 APIGDDNYWHMMRAAGQLN 1027
            .||||.::.:.:|...:::
  Rat   812 HPIGDKSFQNYIRQQSEIS 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	61/125 (49%)
		C2B_RasA3	280..462	CDD:175977	48/181 (27%)
		RasGAP	449..797	CDD:214617	173/348 (50%)
		RasGAP_GAP1_like	473..740	CDD:213330	137/266 (52%)
		PH	761..859	CDD:278594	50/98 (51%)
		PH_GAP1-like	763..867	CDD:269950	50/104 (48%)
		BTK	862..897	CDD:128417	13/34 (38%)
Rasa3	NP_113762.1	C2A_RasA2_RasA3	13..133	CDD:176046	61/134 (46%)
		C2B_RasA3	146..288	CDD:175977	56/273 (21%)
		RasGAP	276..614	CDD:214617	173/363 (48%)
		RasGAP_RASA3	297..565	CDD:213336	137/273 (50%)
		PH_GAP1_mammal-like	562..686	CDD:241522	56/131 (43%)
		PH	577..676	CDD:278594	50/98 (51%)
		BTK	679..714	CDD:128417	13/34 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338168
Domainoid	1	1.000	122	1.000	Domainoid score	I5516
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7217
Inparanoid	1	1.050	628	1.000	Inparanoid score	I814
OMA	1	1.010	-	-		QHG49607
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0000825
OrthoInspector	1	1.000	-	-		otm45898
orthoMCL	1	0.900	-	-		OOG6_104099
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2711
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910