DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RasGAP1 and Rasa4

DIOPT Version :9

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:XP_002727999.1 Gene:Rasa4 / 288589 RGDID:1565457 Length:803 Species:Rattus norvegicus


Alignment Length:978 Identity:247/978 - (25%)
Similarity:391/978 - (39%) Gaps:243/978 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRR 109
            |.::|.|.|||.:::..       |:.|.||.:.:|.|.|.||.|:.:||.||:|||:|..:|..
  Rat     7 LSIRIVEGKNLPAKDIT-------GSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64

  Fly   110 FRYLTIYLWDRD-MKQDKPIGKIAIKREELHMYNHKDH------WFSLRPVDQDSEVQGMVNVEV 167
            |..:..|:.|.| :.:|..|||:.:.|:||     ..|      |..|..||.:.||||.:::.:
  Rat    65 FHMVAFYVMDEDALSRDDVIGKVCLTRDEL-----TSHPKGFIGWTHLVEVDPNEEVQGEIHLRL 124

  Fly   168 AFTEAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAA 232
            ....             |.|..|                            .|.|...|.     
  Rat   125 EVVP-------------GLHASR----------------------------LRCSVLEAR----- 143

  Fly   233 MTLKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK--Q 295
                                                                     |||.|  .
  Rat   144 ---------------------------------------------------------DLAPKDRN 151

  Fly   296 GTCDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLES 360
            |..||||  ..||:.:   |:.|...||:..|.::|...|:|    :.|:|..            
  Rat   152 GASDPFV--RVHYNGR---TQETSVVKKSCYPRWNETFEFEL----EKGATEA------------ 195

  Fly   361 SANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQ-QAVNPSAWYYLQPR 424
                              ::|..|.  ...:|...|||:|   ::|.|.. .|.....|:.||| 
  Rat   196 ------------------LLVEAWD--WDLVSRNDFLGKV---VVNVQTLCSAQQEEGWFRLQP- 236

  Fly   425 SMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESV---D 486
               ..|:|...               ...:|||:|.:....:.|.|...|..|:.||.:.|   .
  Rat   237 ---DQSKSRQG---------------KGNLGSLQLEVRLRDETVLPSVYYQPLVQLLCQEVKLGT 283

  Fly   487 QRPITVSAVSILGELVSG--KTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTL 549
            |.|  ...:.::.|..|.  :.|||..|::||........::..|...|:...::..|:||.|:|
  Rat   284 QGP--GQLIPVIEETTSAECRQEVATTLLKLFLGQGLAKDLLDLLFQLELGRTSEANTLFRSNSL 346

  Fly   550 VSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLH------------ 602
            .||.|:..::::|:.|||..|.|::.::..|||..|:||||::.:....:.||            
  Rat   347 ASKSMESFLKVAGMRYLHGILGPIIDRVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQS 411

  Fly   603 --NLQDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPS--NREVRYSVVSGFIFLRFFAP 663
              .|:.::..:..||.:|...||.|:...|..|.....|.|||  ::.|.:..|:.|:.||||:|
  Rat   412 AQTLRAHLVALLSAICRSVRTCPAVVRATFRQLFRRVRERFPSAQHQNVPFIAVTSFLCLRFFSP 476

  Fly   664 AILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVD 728
            |||.||||.|.....||:|||||.|::|.:|::||:.:..|   ..||.:...|..  ...|.|.
  Rat   477 AILSPKLFHLRERHADARTSRTLLLLAKAVQNIGNMDTPVS---RAKESWMEPLQP--TVRQGVV 536

  Fly   729 AVKHFL-EVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRK--RFGRQFKQRHFRLTT 790
            .:|.|: :::.........:..|.....|  ||  |||.:..:.|..|  .....||:.:|.|||
  Rat   537 QLKDFITKLVDIEEKEELDLQRALNLQAP--PV--KEGPLFIHRTKGKGPLASSSFKKLYFSLTT 597

  Fly   791 HSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTT----NCVEE-RE 850
            .:||:||:...:....|.|..|.:.|::::|||...:..:::::|.....||.    .||.| .:
  Rat   598 EALSFAKTSSSKKSVFIKLASIRAAEKVEEKSFGSSHVMQVIYSDDVGRAQTVYLQCKCVNELNQ 662

  Fly   851 WFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQM-DLVTALDPA 914
            |...|.|:...|:..:..:||..|....:|||.:.::...||    |||.....: :....||..
  Rat   663 WLSALRKVITNNASLLGSYHPGVFRGDKWSCCHQKEKTDLGC----DKTHSRVTLQEWNDPLDHD 723

  Fly   915 LDLQRIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEK 979
            |:.|.|:..::...:.|..      .||.||:...:....    :|........:.|:..|.:..
  Rat   724 LEAQLIYRHLLGVEAALRE------KHQLLSRATEEAGTS----STGRGGAPEDSLAQLLRVLRD 778

  Fly   980 LRE 982
            |||
  Rat   779 LRE 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046 45/130 (35%)
C2B_RasA3 280..462 CDD:175977 41/184 (22%)
RasGAP 449..797 CDD:214617 113/371 (30%)
RasGAP_GAP1_like 473..740 CDD:213330 90/288 (31%)
PH 761..859 CDD:278594 31/104 (30%)
PH_GAP1-like 763..867 CDD:269950 32/110 (29%)
BTK 862..897 CDD:128417 9/34 (26%)
Rasa4XP_002727999.1 C2A_Rasal1_RasA4 6..126 CDD:176018 45/130 (35%)
C2 134..256 CDD:301316 45/274 (16%)
RasGAP 245..604 CDD:214617 113/369 (31%)
RasGAP 264..549 CDD:295371 91/291 (31%)
PH_CAPRI 541..680 CDD:241523 37/142 (26%)
PH 566..671 CDD:278594 33/106 (31%)
BTK 680..708 CDD:279161 10/31 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338170
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D145372at2759
OrthoFinder 1 1.000 - - FOG0000825
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10194
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.850

Return to query results.
Submit another query.