DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and Rasa2

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	XP_038936819.1	Gene:	Rasa2 / 25597	RGDID:	3538	Length:	880	Species:	Rattus norvegicus

Alignment Length:	968	Identity:	319/968 - (32%)
Similarity:	482/968 - (49%)	Gaps:	177/968 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRRFRYLTI 115
            |||||......|.      .||.:|||.|||||:.||..:|::|:|:|.||..|:|||.|:||:.
  Rat    78 EAKNLLPYLGPNK------MRDCFCTINLDQEEVYRTQVVEKSLSPYFSEEFYFEIPRTFQYLSF 136

  Fly   116 YLWDRD-MKQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEVAFTEAQQTQSLS 179
            |::|:: :::|..|||:|||:|:|..::.|:.||||:|:|.:|||||.|::|:...|
  Rat   137 YVYDKNVLQRDLRIGKVAIKKEDLCSHSGKETWFSLQPIDSNSEVQGKVHLELKLNE-------- 193

  Fly   180 EGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAAGLFG 244

  Rat   194 ----------------------------------------------------------------- 193

  Fly   245 HVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQG-TCDPFVVCTAHY 308
                         :|....|...||            .:.:.||..|....| :|||:...:...
  Rat   194 -------------LITENGTVCQQL------------VVHIKACHGLPLINGQSCDPYATVSLVG 233

  Fly   309 SNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKGYSIYPVGG 373
            .:::. .::||.:|||.:|:|:|..||::       :.:::.:.||...:|..           .
  Rat   234 PSRND-QKKTKVKKKTSNPQFNEVFYFEV-------TRSSSYTRKSQFQVEEE-----------D 279

  Fly   374 ADLVEIVVSVWHDAHGAMSDKVFLGEVRLP---MLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNA 435
            .:.:||.:.:|::.:  :...|||||:::|   :.|....|     |||.||||.
  Rat   280 IEKLEIRIDLWNNEN--LVQDVFLGEIKVPVNVLRNDSSHQ-----AWYLLQPRD---------- 327

  Fly   436 TPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGE 500
                    .|.:.|....:|||.|.|.||.|:|.|...|..|..|||:|.|.:|::.||..||||
  Rat   328 --------NGNKSSKPDDLGSLLLTLCYTEDYVLPSEYYGPLKALLLKSPDVQPVSASAAYILGE 384

  Fly   501 LVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHY 565
            :...:.:...|||||..|..::.|.|.|:||.::....|...|||||:|.::.:.|.|::.|.||
  Rat   385 ICRDQKDAVLPLVRLLLHHNKLVPFITAVADLDLKDTQDANAIFRGNSLATQCLTEMMKIVGGHY 449

  Fly   566 LHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIF 630
            |..||:|||.:|....|.|||||.|:|:...|::|..||..||::||.||..|:..||.|:|.||
  Rat   450 LKVTLKPVLDEICESSKSCEIDPVKLKEGDNVESNKENLYYYVDKVFSAIVGSSVSCPTVMCDIF 514

  Fly   631 HDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQS 695
            :.||:.|.:.||:|..|:||.||.|:||||||.|||.|..|.|.....|.||.|||||||||||.
  Rat   515 YSLRQMAAKRFPNNPHVQYSAVSSFVFLRFFAVAILSPHAFHLRPHYPDTQTVRTLTLISKTIQI 579

  Fly   696 LGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFL-EVISTPSHASSSVHPAAAAATPLEP 759
            :||.......:...|:....|..|.|..|::...||.|| |:.||.:..||...         ||
  Rat   580 IGNWGCQSRRKSRFKKSVMCEFLKMFQEERYFTDVKKFLDEISSTETKESSGTS---------EP 635

  Fly   760 VLLKEGLMTKYPTSRKRFGRQ-FKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSF 823
            |.||||.|.|....|.|.|:: ||:|.|.||:..|:|.|.:||..|..||::.|.:||:|::.||
  Rat   636 VHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSKELTYHKQQGKDAIYTIPVKNILAVEKLEESSF 700

  Fly   824 KMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDEN 888
            ..:|.|:::|.:::|.:|..||||..||.|:|.::...|..|:..|||||:::|.:.||..:.|.
  Rat   701 NKKNMFQVIHTEKTLYIQANNCVEANEWIDMLCRVSRCNHNRLSSFHPSAYLNGNWLCCQETSEG 765

  Fly   889 SPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHN 953
            :||||..........|:|    :|...:.:||:::...::..|:.:.:..   .|::..|..|..
  Rat   766 TPGCKPCTAGIPADIQID----IDEDRETERIYSVFTLSLLKLQKMEEAC---GSIAVYQGPQKE 823

  Fly   954 PLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAPI 1011
            |.....|     ...:.|.|| ||::::.....:|..|..|::..:...||||::.||
  Rat   824 PGYSKFT-----IEDSVATFK-TIQQIKSTIEKLDEPHEKYRKKRSSSAKYGSKENPI 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	56/118 (47%)
		C2B_RasA3	280..462	CDD:175977	44/185 (24%)
		RasGAP	449..797	CDD:214617	154/349 (44%)
		RasGAP_GAP1_like	473..740	CDD:213330	120/267 (45%)
		PH	761..859	CDD:278594	42/98 (43%)
		PH_GAP1-like	763..867	CDD:269950	43/104 (41%)
		BTK	862..897	CDD:128417	15/34 (44%)
Rasa2	XP_038936819.1	C2A_RasA2_RasA3	78..191	CDD:176046	56/118 (47%)
		C2B_RasA3	204..346	CDD:175977	46/197 (23%)
		RasGAP	355..625	CDD:413381	120/269 (45%)
		PH_GAP1m_mammal-like	622..754	CDD:241521	56/140 (40%)
		BTK	739..774	CDD:128417	15/34 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338171
Domainoid	1	1.000	122	1.000	Domainoid score	I5516
eggNOG	1	0.900	-	-		E1_KOG2059
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	628	1.000	Inparanoid score	I814
OMA	1	1.010	-	-		QHG49607
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0000825
OrthoInspector	1	1.000	-	-		otm45898
orthoMCL	1	0.900	-	-		OOG6_104099
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2711
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770