DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RasGAP1 and gap1

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	NP_001342789.1	Gene:	gap1 / 2540440	PomBaseID:	SPBC646.12c	Length:	766	Species:	Schizosaccharomyces pombe

Alignment Length:	756	Identity:	161/756 - (21%)
Similarity:	261/756 - (34%)	Gaps:	231/756 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 GAMSDKVFLGEVRLPMLNKQEQQAV-----------NPSAWYYLQPRSMTHSSRSLNATPRSCAT 442
            |.:|..|.....||.:|..:|..:|           ...|:::|. |.:....:.:::..:....
pombe     7 GTLSSSVLPQTNRLSLLRNRESTSVLYTIDLDMESDVEDAFFHLD-RELHDLKQQISSQSKQNFV 70

  Fly   443 PPGTRLSVDSTIGSL---------------RLNLNYTA-DHVFP----LATYDDLMNLL------ 481
            .......:||.|..|               |||.||.| ...||    |..|..|..||
pombe    71 LERDVRYLDSKIALLIQNRMAQEEQHEFAKRLNDNYNAVKGSFPDDRKLQLYGALFFLLQSEPAY 135

  Fly   482 LESVDQRP--------ITVSAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLT 538
            :.|:.:|.        :.:...:|.|.....:.|  ..|:.||          :.:...|....:
pombe   136 IASLVRRVKLFNMDALLQIVMFNIYGNQYESREE--HLLLSLF----------QMVLTTEFEATS 188

  Fly   539 DPTTIFRGNTLVSKMMDEAMRLS-GLHYLHQTLRPVLSQI---------------------VAEK 581
            |..::.|.||.||:|:....|.. |..||...|...::.:                     ..:.
pombe   189 DVLSLLRANTPVSRMLTTYTRRGPGQAYLRSILYQCINDVAIHPDLQLDIHPLSVYRYLVNTGQL 253

  Fly   582 KPCEID--------------PSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCP---KVLCQI 629
            .|.|.|              .:.|::|||      .|....:|..:|:..|.|..|   :.:|::
pombe   254 SPSEDDNLLTNEEVSEFPAVKNAIQERSA------QLLLLTKRFLDAVLNSIDEIPYGIRWVCKL 312

  Fly   630 FHDLRECAGEHFPS-NREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTS----RTLTLI 689
               :|......||| :.....|::.||.||||..|||:.|:    |:..||:..|    :||..|
pombe   313 ---IRNLTNRLFPSISDSTICSLIGGFFFLRFVNPAIISPQ----TSMLLDSCPSDNVRKTLATI 370

  Fly   690 SKTIQSLGNLVSSR------SSQQTCK--EEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSS 746
            :|.|||:.|..||.      |.|...|  ||....|.:|      :..|..|.|.:....:.:.|
pombe   371 AKIIQSVANGTSSTKTHLDVSFQPMLKEYEEKVHNLLRK------LGNVGDFFEALELDQYIALS 429

  Fly   747 VHPAAAAATPLEPVL----LKEGLMTKY-PTSRKRFGRQFKQRHFRLTTHSLSYAKSKGKQPICD 806
            ....|...|..|..|    :.|.|...| |.|           |..|....|.       :|...
pombe   430 KKSLALEMTVNEIYLTHEIILENLDNLYDPDS-----------HVHLILQELG-------EPCKS 476

  Fly   807 IPLQEIASVEQLKDKSFKMQNCFKI--VHN--DRSLIVQTTNCVEEREWFDLLH---KICLMNSI 864
            :|.::               ||...  ::|  |.|:.....|....||  |:|:   |...:..:
pombe   477 VPQED---------------NCLVTLPLYNRWDSSIPDLKQNLKVTRE--DILYVDAKTLFIQLL 524

  Fly   865 R-MQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNM 928
            | :...||:..|                            .:||....|....|:.: :|:...:
pombe   525 RLLPSGHPATRV----------------------------PLDLPLIADSVSSLKSM-SLMKKGI 560

  Fly   929 SVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHR- 992
            ..:| |||.|:..:.:     .:.|...||.::::|.    |.:.....|::|.:..|:...||
pombe   561 RAIE-LLDELSTLRLV-----DKENRYEPLTSEVEKE----FIDLDALYERIRAERDALQDVHRA 615

  Fly   993 --DYKQGITRQLK-YGSRQAPIGDDNYWHMMRAAGQLNQQH 1030
              |:.:.:..||: |||           ::..|..|:...|
pombe   616 ICDHNEYLQTQLQIYGS-----------YLNNARSQIKPSH 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046
		C2B_RasA3	280..462	CDD:175977	18/98 (18%)
		RasGAP	449..797	CDD:214617	104/438 (24%)
		RasGAP_GAP1_like	473..740	CDD:213330	78/332 (23%)
		PH	761..859	CDD:278594	22/109 (20%)
		PH_GAP1-like	763..867	CDD:269950	22/112 (20%)
		BTK	862..897	CDD:128417	4/35 (11%)
gap1	NP_001342789.1	RasGAP_C	<1..766	CDD:332048	161/756 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R472
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030