DRSC/TRiP Functional Genomics Resources

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Protein Alignment RasGAP1 and Rasal2

DIOPT Version :9

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:XP_006496813.1 Gene:Rasal2 / 226525 MGIID:2443881 Length:1289 Species:Mus musculus


Alignment Length:1203 Identity:246/1203 - (20%)
Similarity:401/1203 - (33%) Gaps:380/1203 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 DQDSEVQGMVNVEVAFTEAQQTQSL------------SEGIDLGQHTLRHHQNLPHHSHQQRAHL 206
            :::..|:|         :.|||.|.            |||            ..|.:..:....|
Mouse   108 EKEMPVEG---------QDQQTDSTKGRCLRRTVSVPSEG------------QFPEYPQEGTTKL 151

  Fly   207 NDYKENSELSNIQRASAAAASSSSAAMTLKT------RAAGLF-----GHVHHPPSQTQ------ 254
            ....|.|.    :|.|.:..|:|....::.|      :..|.|     |.:....||::      
Mouse   152 EVPAERSP----RRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTS 212

  Fly   255 -HFPIINTTSTSS---DQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHYSNKHQ-- 313
             ..|.:......|   .:|...:||...:.....| .|:||    |..:|..|...|.|...|  
Mouse   213 FRLPSLRNADDRSRGLPKLKESRSHESLLSPCSAV-ECLDL----GRGEPVSVKPLHSSILGQDF 272

  Fly   314 -----------------VTRRTK---QRKKTVDPEFD---------------------EAMYF-D 336
                             .:.|.|   ..::||.|..|                     :..|| :
Mouse   273 CFEVTYLSGSKCFSCSSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCE 337

  Fly   337 LHIDADAGSTNTTGSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAH-GAMSDK-VFLGE 399
            |.:| |.....||...|:.........:.||:.|     |..|.|.::.|.. ....|| .::|.
Mouse   338 LCLD-DTLFARTTSKTKADNIFWGEHFEFYSLPP-----LHSITVHIYKDVEKKKKKDKNNYVGL 396

  Fly   400 VRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIG-SLRLNLNY 463
            |.:|..:...:|.|  ..||                 |.|..||     :...|.| |:|:...:
Mouse   397 VNIPTASVTGRQFV--EKWY-----------------PVSTPTP-----NKGKTGGPSIRIKSRF 437

  Fly   464 TADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVS--GKTEVAQPLVRLFTHTERIAPII 526
            ....:.|:..|.:....:..:.      ....|:|..::|  .|.|:|..||.:...|.|....:
Mouse   438 QTITILPMEQYKEFAEFITSNY------TMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFL 496

  Fly   527 KALADHEISHLTD-PTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSK 590
            ..|...|:....: ...|||.||:.:|.::|.::|.|..|||..|...:..:....:.||:||||
Mouse   497 TDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK 561

  Fly   591 IKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREVRYSVVSG 654
            ......:| :..||:...|..|..|..|....|:.|.::|...: :|...   ..:::...::|.
Mouse   562 CSSSELMD-HQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR---GKQDISERLISA 622

  Fly   655 FIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVEL-- 717
            .:||||..|||:.|.||:|..|..|.:||||||||:|.||:|.|.....:     |||:...:  
Mouse   623 SLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN-----KEEYMAFMND 682

  Fly   718 --------YKKFCTE--------------QHVD-----AVKHFL--EVISTPSHASSSVHPAAAA 753
                    .|:|..|              .::|     :|.|.|  ||:|......:|...|..|
Mouse   683 FLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVA 747

  Fly   754 AT-PLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHS----LSYAKSKGKQPICDIPLQEIA 813
            .. ||..||..   :||..|:.....:|.:    |...||    :|.:.|.|.|.||:.|..  :
Mouse   748 KLGPLPRVLAD---ITKSLTNPTPIQQQLR----RFAEHSSSPNVSGSLSSGLQRICEDPTD--S 803

  Fly   814 SVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGF 878
            .:.:||..|  ..|..........|:||..                  :|..|.|....      
Mouse   804 DLHKLKSPS--QDNTDSYFRGKTLLLVQQA------------------SSQSMTYSEKD------ 842

  Fly   879 YSCCGRSDENS-PGCKKVLDKTMDYFQMDLVTALDPALDLQRIHT---------------LIMSN 927
                  ..||| |..:.:                 ..:|||..|.               |..|.
Mouse   843 ------EKENSLPNGRSI-----------------SLMDLQDTHAAQAEHASVMLDVPMRLAGSQ 884

  Fly   928 MSVLE-SLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAF----------------AEFKR 975
            :|:.: :.:..|...||..|:..|...||.|.........|.:|                |....
Mouse   885 LSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGSLQPLSFQNPVYHLNNPVPAMPKASADS 949

  Fly   976 TIEKLREKAYAIDRDHRDYK---------QGITRQLKYG---SRQAPIGDDN------------- 1015
            ::|.|...:.....:..|:|         :..|::..:.   ||:..:.|.:             
Mouse   950 SLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSSHSEDFSRRHTVPDRHIPLALPRQNSTGQ 1014

  Fly  1016 ----------------------YWHMMRAAGQL-------------NQQHHQQQQHQQQQ----- 1040
                                  :...:|:.|.:             |....:||....::     
Mouse  1015 SQIRKLDHSGLGARAKAPPSLPHSASLRSTGSMSVASAALMAEPVQNGSRSRQQSSSSRESPVPK 1079

  Fly  1041 ----QQQQQQQLQQFQPQPVLPQMQNVRAYPYQPAT----SNMNAYCLHNMQYQQ--QRLPFHQQ 1095
                |:||.||:|.                |...||    ....|:.|:|.||::  :....:|.
Mouse  1080 VRAIQRQQTQQVQS----------------PVDSATMSPVERTAAWVLNNGQYEEDVEETEQNQD 1128

  Fly  1096 QQQHHQQLQQQQSQFQP---LRSHQLQRHNNNL 1125
            :.:|.::.:|:.::.:.   :.|.:|:.:...|
Mouse  1129 EAKHAEKYEQEITKLKERLRVSSRRLEEYERRL 1161

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046 2/14 (14%)
C2B_RasA3 280..462 CDD:175977 48/228 (21%)
RasGAP 449..797 CDD:214617 103/388 (27%)
RasGAP_GAP1_like 473..740 CDD:213330 83/301 (28%)
PH 761..859 CDD:278594 22/101 (22%)
PH_GAP1-like 763..867 CDD:269950 22/107 (21%)
BTK 862..897 CDD:128417 7/35 (20%)
Rasal2XP_006496813.1 PH-like 181..364 CDD:388408 34/188 (18%)
C2_SynGAP_like 306..445 CDD:175980 34/168 (20%)
RasGAP_DAB2IP 436..766 CDD:213338 94/347 (27%)
DUF3498 756..1232 CDD:371844 80/480 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834587
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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