DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RasGAP1 and Rasa1

DIOPT Version :9

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:NP_663427.2 Gene:Rasa1 / 218397 MGIID:97860 Length:1038 Species:Mus musculus


Alignment Length:777 Identity:165/777 - (21%)
Similarity:301/777 - (38%) Gaps:181/777 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 DTREVRIEEQLKVKIGEAKNLSSRNAANTSCS--------TQGTRDVY--CTIALDQEEICRTPT 89
            |..|.:|....|:...||.||..  .....||        |.|...:|  ....:.:.:||.|| 
Mouse   335 DPHEGKIWFHGKISKQEAYNLLM--TVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTP- 396

  Fly    90 IERTLTPFFGEEHQFKIPRRFRYLTIYLWDRDMKQDKPIGKIA--IKREELHMYNHKDHWFSLRP 152
                       .:||.:..|:.              ..||.|.  .::|::     .:.::...|
Mouse   397 -----------NNQFMMGGRYY--------------NSIGDIIDHYRKEQI-----VEGYYLKEP 431

  Fly   153 VD-QDSEVQGMVNVEVAFTEAQQTQSLSEGIDLGQ---HTLRH------HQNLPHHSH------- 200
            |. ||                 |.|.|::.:| |:   :|:|.      ::|:....:       
Mouse   432 VPMQD-----------------QGQVLNDTVD-GKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKG 478

  Fly   201 QQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAA-----GLFGHVHHPPSQTQHFP--- 257
            ::..:|....|.|:...|...|...|:.....:.|...:.     .|||..:......|||.   
Mouse   479 KRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEH 543

  Fly   258 -IINTTSTSSDQLSNW-KSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAH------------- 307
             |......:.:|..:| |....|..:....|...:...:|.:.....:..||             
Mouse   544 YIFYFAGETPEQAEDWMKGLQAFCSLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCN 608

  Fly   308 -YSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKGYSIYPV 371
             |.|..||.:  ...::..:|.:.|...|| .:..|......|.|||:..|.:            
Mouse   609 IYLNSVQVAK--THAREGQNPVWSEEFVFD-DLPPDINRFEITLSNKTKKSKD------------ 658

  Fly   372 GGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNAT 436
              .|::.:...:.....|..:|:.||....:|:      :.:.|                     
Mouse   659 --PDILFMRCQLSRLQKGHATDEWFLLSSHIPL------KGIEP--------------------- 694

  Fly   437 PRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGEL 501
                              ||||:...|:.:.:.|...|.:...|:|:.  :..:..:...:.|: 
Mouse   695 ------------------GSLRVRARYSMEKIMPEEEYSEFKELILQK--ELHVVYALSHVCGQ- 738

  Fly   502 VSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYL 566
              .:|.:|..|:::|.|.:..:.::..|.|.|||...:.||:||..||.|.:|::.|:.:...::
Mouse   739 --DRTLLASILLKIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFV 801

  Fly   567 HQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFH 631
            |..|:..:.:|:..|:.||:.|||::....|:|||.:|...:..:.|.|..:::..|..|..|:.
Mouse   802 HHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLAHLLSILSELVEKIFMASEILPPTLRYIYG 866

  Fly   632 DLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSL 696
            .|::.....:|:|..:|..|||||:|||...||||.|::|::.::......:|||||::|::|:|
Mouse   867 CLQKSVQHKWPTNNTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLTLVAKSVQNL 931

  Fly   697 GNLVSSRSSQQTCKEEFTVELYKKFCTEQH-----VDAVKHFLEVISTPSHASSSVHPAAAA 753
            .|||     :...||.:...:.....:.:|     :|.:.:..|:..|..|:.:.:....||
Mouse   932 ANLV-----EFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAA 988

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046 25/137 (18%)
C2B_RasA3 280..462 CDD:175977 29/195 (15%)
RasGAP 449..797 CDD:214617 86/310 (28%)
RasGAP_GAP1_like 473..740 CDD:213330 76/271 (28%)
PH 761..859 CDD:278594
PH_GAP1-like 763..867 CDD:269950
BTK 862..897 CDD:128417
Rasa1NP_663427.2 SH2_Nterm_RasGAP 152..255 CDD:198216
SH3_RasGAP 272..330 CDD:212722
SH2_Cterm_RasGAP 341..417 CDD:198217 21/103 (20%)
PH 480..568 CDD:278594 18/87 (21%)
PH_RASA1 480..567 CDD:270080 17/86 (20%)
C2_Ras_p21A1 582..707 CDD:176045 29/186 (16%)
RasGAP 689..1035 CDD:214617 87/355 (25%)
RasGAP_p120GAP 705..1036 CDD:213340 81/294 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D145372at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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