DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and Rasal1

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	NP_001346073.1	Gene:	Rasal1 / 19415	MGIID:	1330842	Length:	799	Species:	Mus musculus

Alignment Length:	994	Identity:	269/994 - (27%)
Similarity:	414/994 - (41%)	Gaps:	266/994 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRR 109
            |.:::.|.:.|.:::.:       |:.|.||.:.:|.:.:.||.||.|:|:||:|||:...:|..
Mouse     7 LSIRVVEGRALPAKDVS-------GSSDPYCLVKVDDQVVARTATIWRSLSPFWGEEYTVHLPLD 64

  Fly   110 FRYLTIYLWDRD-MKQDKPIGKIAIKREELHMYNHK-DHWFSLRPVDQDSEVQGMVNVEVAFTEA 172
            |.:|..|:.|.| :..|..||||::.:|.:...... |.|.:|..||.|:||||.|.::|...|.
Mouse    65 FHHLAFYVLDEDTVGHDDIIGKISLSKEAITADPRGIDSWINLSRVDPDAEVQGEVCLDVKLLED 129

  Fly   173 QQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKT 237
            .:.:.|                        |.|:...:
Mouse   130 ARGRCL------------------------RCHVRQAR--------------------------- 143

  Fly   238 RAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK--QGTCDP 300
                                                                |||.:  .||.||
Mouse   144 ----------------------------------------------------DLAPRDISGTSDP 156

  Fly   301 FVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKG 365
            |  ....:.| |.:  .|...|||..|.:||.    |.:....|:|:
Mouse   157 F--ARVFWGN-HSL--ETSTIKKTRFPHWDEV----LELREAPGTTS------------------ 194

  Fly   366 YSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSS 430
                        .:.|.:|.......:|  |||.|.   ...|..|...|:.|:.|.|......|
Mouse   195 ------------PLRVELWDWDMVGKND--FLGMVE---FTPQTLQQKPPNGWFRLLPFPRAEDS 242

  Fly   431 RSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPI---TV 492
                                ..::|:|||.:..|.|.|.|...|..||.|||||| |.|.   |.
Mouse   243 --------------------GGSLGALRLKVRLTEDRVLPSQYYQPLMELLLESV-QGPAEEDTT 286

  Fly   493 SAVSILGELVSG--KTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMD 555
            |.:::|.||.||  :.::|..||:||.......|.:..|...|::...||.|:||.|:|.||.|:
Mouse   287 SPLALLEELASGDCRQDLATKLVKLFLGRGLAGPFLDYLTRREVARTNDPNTLFRSNSLASKSME 351

  Fly   556 EAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKI--------------KDRSAVDTNLHNLQD 606
            :.|:|.|:.|||:.||||:|::..|||..|:||.|:              .:....:|:|..|..
Mouse   352 QFMKLVGMRYLHEVLRPVISRVFEEKKYMELDPCKMDLNRSRRISFKGTPTEEQVRETSLGLLTG 416

  Fly   607 YVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFP--SNREVRYSVVSGFIFLRFFAPAILGPK 669
            |:..|.:||..|..|||..|...|..|:.|..:.|.  .:::|:|..:|||:||||||||||.||
Mouse   417 YLGSVVDAIVSSTGRCPLALRLAFKQLQRCVEKRFSGIEHQDVKYLAISGFLFLRFFAPAILTPK 481

  Fly   670 LFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQ--TCKEEFTVELYKKFCTEQHVDAVKH 732
            ||||..:..|.||||:|.|::|.:||:|||     .||  ..||::...|:....  |.:..|:.
Mouse   482 LFDLRDQHADPQTSRSLLLLAKAVQSIGNL-----GQQLGQGKEQWLAPLHPFLL--QSISRVRD 539

  Fly   733 FLEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRK--------RFGRQFKQRHFRLT 789
            ||:.:........:..||.|...|  ..:::||.:.|    ||        ||.  ||:|:|||:
Mouse   540 FLDQLVDVDEDEEAGGPACALVQP--STIVREGFLLK----RKEEPGGLATRFA--FKKRYFRLS 596

  Fly   790 THSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHND-----RSLIVQTTNCVEER 849
            ...|||:|:...|....|||..|.:||.:.:.:|::.:..::|..|     .:..:|..|..:..
Mouse   597 GRDLSYSKTPEWQVHTSIPLSCIRAVEHVDEGAFQLPHVMQVVTQDGAGTSHTTYLQCKNVNDLN 661

  Fly   850 EWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDK-TMDYFQMDLVTALDP 913
            :|...|.|....|..::...||.||.||.::||.:::.::.||.:.... |:.    |....|||
Mouse   662 QWLSALRKASAPNPGKLVACHPGAFRSGRWTCCLQAERSAAGCSRTHSAITLG----DWSDPLDP 722

  Fly   914 ALDLQRIHTLIMSNM----------SVLESLLDP------------LTYHQSLSQTQHQQHNPLV 956
            ..:.|.::..::...          |.|::.:||            ....|..:.|.|     |:
Mouse   723 DAEAQAVYRQLLLGRDQLRLKLLEDSSLDTEVDPGRDSSATDGPCAEVLAQQRAATTH-----LL 782

  Fly   957 PLATDLQKHSPQAFAEFKR 975
            .:..||:    ||..||::
Mouse   783 QVLEDLE----QAHEEFQK 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	43/125 (34%)
		C2B_RasA3	280..462	CDD:175977	38/183 (21%)
		RasGAP	449..797	CDD:214617	141/378 (37%)
		RasGAP_GAP1_like	473..740	CDD:213330	113/289 (39%)
		PH	761..859	CDD:278594	32/110 (29%)
		PH_GAP1-like	763..867	CDD:269950	33/116 (28%)
		BTK	862..897	CDD:128417	11/34 (32%)
Rasal1	NP_001346073.1	C2	6..126	CDD:387358	43/125 (34%)
		C2	134..254	CDD:387358	41/286 (14%)
		RasGAP_RASAL	262..548	CDD:213337	114/293 (39%)
		PH-like	552..689	CDD:388408	41/144 (28%)
		BTK	681..705	CDD:366299	9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834592
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000825
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840