DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and Rasa3

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	NP_033051.2	Gene:	Rasa3 / 19414	MGIID:	1197013	Length:	834	Species:	Mus musculus

Alignment Length:	994	Identity:	359/994 - (36%)
Similarity:	535/994 - (53%)	Gaps:	176/994 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VRIEEQLKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQ 103
            :|:.:.:::||||||||.|....|.      .||.|||:.|||||:.||..:|::|.||:||:..
Mouse     8 LRVFQSVRIKIGEAKNLPSYPGPNK------MRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFY 66

  Fly   104 FKIPRRFRYLTIYLWDRDM-KQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEV 167
            .:|||.||:|:.|::|||: ::|..|||:||::|:|..|:::|.||.|:.||.||||||.|::|:
Mouse    67 CEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQRYHNRDTWFQLQHVDADSEVQGKVHLEL 131

  Fly   168 AFTEAQQTQSLSEGI-DLGQ--HTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSS 229
                     .|||.| |.|.  |.|
Mouse   132 ---------RLSEVITDTGVVCHKL---------------------------------------- 147

  Fly   230 SAAMTLKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK 294
                     ||.:|        :.|..||:|
Mouse   148 ---------AARIF--------ECQGLPIVN---------------------------------- 161

  Fly   295 QGTCDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLE 359
             |.|||:...|.....:.: .::||.:|||.:|:|||..||::       :...:.|.||....|
Mouse   162 -GQCDPYATVTLAGPFRSE-AKKTKVKKKTNNPQFDEVFYFEV-------TRPCSYSKKSHFDFE 217

  Fly   360 SSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPR 424
            ..           ..|.:||.|.:|:.::....|: ||||:|||:  |..:.:.:..|||:||||
Mouse   218 EE-----------DVDKLEIRVDLWNASNLKFGDE-FLGELRLPL--KILRHSSSYEAWYFLQPR 268

  Fly   425 SMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRP 489
            .  :.::||.                ...:||||||:.||.||||....|..|.:|||:|.|..|
Mouse   269 D--NGNKSLK----------------PDDLGSLRLNVVYTEDHVFSSEYYSPLRDLLLKSADVEP 315

  Fly   490 ITVSAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMM 554
            ::.||..||||:...|.|.|.|||||..|..|:.|.|.|:|..|:....||.||||||:|.||.:
Mouse   316 VSASAAHILGEVCRDKQEAAIPLVRLLLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLTSKCI 380

  Fly   555 DEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSA 619
            ||.|:|:|:||||.||:|.:.:|....|.|||||.|:||...::.|:.:|:.||:|:|..||||.
Mouse   381 DETMKLAGMHYLHVTLKPTIEEICQSHKSCEIDPVKLKDGENLENNMESLRQYVDRIFTVITKSG 445

  Fly   620 DRCPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSR 684
            ..||.|:|.||..|||.|.:.|..:.:|||:.||.||||||||||||.|.||.||....|.||||
Mouse   446 VSCPTVMCDIFFSLREAAAKRFQDDLDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSR 510

  Fly   685 TLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHP 749
            ||||||||||:||:|  |:|...:.||.:....|:.|..:::.||||:||::||    :|....|
Mouse   511 TLTLISKTIQTLGSL--SKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLIS----SSGRRDP 569

  Fly   750 AAAAATPLEPVLLKEGLMTKYPTSRKRFG-RQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIA 813
            .:..    :|:|||||.|.|....||||| :.||:|.||||.|..:|.||||.||:|:||::.|.
Mouse   570 KSIE----QPILLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKGDQPLCNIPIENIL 630

  Fly   814 SVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGF 878
            :||:|:::||:|:|.|:::..:|:|.:|..||||.::|.|:|.|:...|..|:..|||||:::|.
Mouse   631 AVERLEEESFRMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVFHPSAYLNGH 695

  Fly   879 YSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQS 943
            :.||..|.:.:.||...........|:|    :|...:.:||::|....|..||.:.:.......
Mouse   696 WLCCRASSDTAAGCTPCTGGLPANIQLD----IDGDRETERIYSLFNLYMGKLEKMQEACGSKSV 756

  Fly   944 LSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQ 1008
            ....:.::::..|       ...||   |..:|::::......::::|..|::...::.:|||::
Mouse   757 YDGPEQEEYSTFV-------IDDPQ---ETYKTLKQVIAGVGTLEQEHAQYRRDKFKKTRYGSQE 811

  Fly  1009 APIGDDNYWHMMRAAGQLN 1027
            .||||.::.:.:|...:::
Mouse   812 HPIGDKSFQNYIRQQSEIS 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	61/125 (49%)
		C2B_RasA3	280..462	CDD:175977	49/181 (27%)
		RasGAP	449..797	CDD:214617	173/348 (50%)
		RasGAP_GAP1_like	473..740	CDD:213330	137/266 (52%)
		PH	761..859	CDD:278594	50/98 (51%)
		PH_GAP1-like	763..867	CDD:269950	50/104 (48%)
		BTK	862..897	CDD:128417	13/34 (38%)
Rasa3	NP_033051.2	C2A_RasA2_RasA3	13..133	CDD:176046	61/134 (46%)
		C2B_RasA3	146..288	CDD:175977	57/273 (21%)
		RasGAP	275..614	CDD:214617	174/364 (48%)
		RasGAP_RASA3	297..565	CDD:213336	137/273 (50%)
		PH_GAP1_mammal-like	562..686	CDD:241522	56/131 (43%)
		PH	577..676	CDD:278594	50/98 (51%)
		BTK	679..714	CDD:128417	13/34 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834588
Domainoid	1	1.000	122	1.000	Domainoid score	I5635
eggNOG	1	0.900	-	-		E1_KOG2059
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7217
Inparanoid	1	1.050	629	1.000	Inparanoid score	I851
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49607
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0000825
OrthoInspector	1	1.000	-	-		otm43818
orthoMCL	1	0.900	-	-		OOG6_104099
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R472
SonicParanoid	1	1.000	-	-		X2711
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800