DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and Syngap1

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	NP_851606.3	Gene:	Syngap1 / 192117	RGDID:	621090	Length:	1308	Species:	Rattus norvegicus

Alignment Length:	1255	Identity:	261/1255 - (20%)
Similarity:	406/1255 - (32%)	Gaps:	360/1255 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 YCTIA------LDQEEI------------CRTPTIERTLT-PFFGE---EHQFKIPRRFRYLTIY 116
            :|.|:      ||::||            .|...:.||:: |..|.   ||::.:
  Rat    48 FCIISGNQLLMLDEDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHL---------- 102

  Fly   117 LWDRDMKQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEVAFTEAQQTQSLSEG 181
              .|..::..|.|              |.:.....|.......||.::..:. :..::|:|..:
  Rat   103 --GRSRRKSVPGG--------------KQYSMEAAPAAPFRPSQGFLSRRLK-SSIKRTKSQPK- 149

  Fly   182 IDLGQHTLRHHQNLPHH---SHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAAGLF 243
            :|   .|....|.||..   .|.:...:..:||:.     ...|..:.||::.|:.|......:.
  Rat   150 LD---RTSSFRQILPRFRSADHDRARLMQSFKESH-----SHESLLSPSSAAEALELNLDEDSII 206

  Fly   244 GHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHY 308
            ..| |.....|.|....|||:.:                 |..||...|::    |.::
  Rat   207 KPV-HSSILGQEFCFEVTTSSGT-----------------KCFACRSAAER----DKWI------ 243

  Fly   309 SNKHQVTRRTKQRKKTVD--------------PEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLE 359
            .|..:..:..|...:.||              |:  :..|.:|.:| |.....||...:||.
  Rat   244 ENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPK--KRYYCELCLD-DMLYARTTSKPRSAS--- 302

  Fly   360 SSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGE------------VRLPMLNKQEQQA 412
                                            .|.||.||            :||.:....:::.
  Rat   303 --------------------------------GDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKR 335

  Fly   413 VNPSAWYY---------LQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIG------------- 455
            ....|.|.         |..|..|.     ...|.:..|..|....:.|..|
  Rat   336 KKDKAGYVGLVTVPVATLAGRHFTE-----QWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKG 395

  Fly   456 ---SLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVSGKTEVAQPLVRLFT 517
               ::||...|....:.|:..|.:    ..|.|......:.||......|.||.|||..||.:..
  Rat   396 GCPAVRLKARYQTMSILPMELYKE----FAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQ 456

  Fly   518 HTERIAPIIKALADHEI------SHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQ 576
            .|.:....:..:|..|:      .||     |||.|||.:|.::|.|||.|..||...:...:..
  Rat   457 STGKAKDFLSDMAMSEVDRFMEREHL-----IFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRA 516

  Fly   577 IVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLR-ECAGEH 640
            :...::.||:||.|. ..|::..:..||:...|.....:..|....|..|.::|...| .||..
  Rat   517 LYESEENCEVDPIKC-TASSLAEHQANLRMCCELALCKVVNSHCVFPGELKEVFASWRLRCAER- 579

  Fly   641 FPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSS 705
              ...::...::|..:||||..|||:.|.||.|..|..|.|||||||||:|.||:|.|.     |
  Rat   580 --GREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANF-----S 637

  Fly   706 QQTCKEEFTVELYKKFCTEQHVDAVKHFLEVIS---TPSHAS------------SSVHPAAAAAT 755
            :.|.||:| :....:| .|....:::.||..||   |.:::|            |::|   |...
  Rat   638 KFTSKEDF-LGFMNEF-LELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLH---ALLW 697

  Fly   756 PLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIASVEQLKD 820
            .:.|.|.||.|:...|..|.........|:..:.......::....||:.            |:.
  Rat   698 EVLPQLSKEALLKLGPLPRLLSDISTALRNPNIQRQPSRQSERARSQPMV------------LRG 750

  Fly   821 KSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSG-------- 877
            .|.:||....                  |:         |.:||.:|.|......|.
  Rat   751 PSAEMQGYMM------------------RD---------LNSSIDLQSFMARGLNSSMDMARLPS 788

  Fly   878 -----------------FYSCCGRSDENSPG-CKKVLDKTMDYFQMDLVTALDPALDLQ------ 918
                             ||........:||. |....|.|....:|..|......||||
  Rat   789 PTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGG 853

  Fly   919 RIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREK 983
            |:::..:||::.:..||.  :...||:.....:..|    |..|.:.|..:.     |...:|..
  Rat   854 RLNSSSVSNLAAVGDLLH--SSQASLTAALGLRPAP----AGRLSQGSGSSI-----TAAGMRLS 907

  Fly   984 AYAIDRDHRDYKQGITRQLKYGSRQAPIGDDN-YWHMMRAA---------------GQLNQQHHQ 1032
            ...:..|      |:..|    ..:.|:...| .:||  ||               |..:..||.
  Rat   908 QMGVTTD------GVPAQ----QLRIPLSFQNPLFHM--AADGPGPPAGHGGSSGHGPPSSHHHH 960

  Fly  1033 QQQHQQQQQQQQQQQLQQFQPQPVLPQMQNVRAYPYQPATSNMNAYCLHNMQYQQQRLP----FH 1093
            ...|..:..:........|........:..  ..|..||.|     .||:..|..:..|    |.
  Rat   961 HHHHHHRGGEPPGDTFAPFHGYSKSEDLST--GVPKPPAAS-----ILHSHSYSDEFGPSGTDFT 1018

  Fly  1094 QQQQQHHQQLQQQQSQFQ----PLRSHQLQRHNNNLNNNNCGNGSSSSP-------SSTTSSVVA 1147
            ::|......||...|..|    |.|.........:...:..|.|....|       ..|.|:...
  Rat  1019 RRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQK 1083

  Fly  1148 APPSTTSSSQPAPPIYXRSR 1167
            ..||:.:..|...|.| .:|
  Rat  1084 PRPSSGNLLQSPEPSYGPAR 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	20/116 (17%)
		C2B_RasA3	280..462	CDD:175977	37/232 (16%)
		RasGAP	449..797	CDD:214617	106/385 (28%)
		RasGAP_GAP1_like	473..740	CDD:213330	87/276 (32%)
		PH	761..859	CDD:278594	14/97 (14%)
		PH_GAP1-like	763..867	CDD:269950	16/103 (16%)
		BTK	862..897	CDD:128417	10/60 (17%)
Syngap1	NP_851606.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..113		5/32 (16%)
		PH_SynGAP	122..313	CDD:270178	48/266 (18%)
		PH	<188..251	CDD:278594	17/90 (19%)
		C2_SynGAP_like	252..414	CDD:175980	32/204 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..394		2/20 (10%)
		RasGAP	401..720	CDD:214617	103/341 (30%)
		RasGAP_DAB2IP	405..728	CDD:213338	102/345 (30%)
		DUF3498	718..1295	CDD:288827	81/455 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..751		4/37 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..809		2/27 (7%)
		SH3-binding. /evidence=ECO:0000255	785..815		2/29 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1017		17/93 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1153		15/71 (21%)
		Rho_Binding	1196..1255	CDD:286056
		Interaction with MPDZ. /evidence=ECO:0000269\|PubMed:15312654	1197..1308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1276..1308
		PDZ-binding. /evidence=ECO:0000255	1305..1308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338173
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840