DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RasGAP1 and Nf1

DIOPT Version :9

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:XP_006532499.1 Gene:Nf1 / 18015 MGIID:97306 Length:2852 Species:Mus musculus


Alignment Length:831 Identity:167/831 - (20%)
Similarity:283/831 - (34%) Gaps:264/831 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 DKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEVA-----------------FTEA 172
            |.|:.:...:...|.:.||:.....:|     :.|:.:|.:|::                 |.::
Mouse   900 DSPVSRFMDRLLSLMVCNHEKVGLQIR-----TNVKDLVGLELSPALYPMLFNKLKNTISKFFDS 959

  Fly   173 QQTQSLSE-GIDLGQHTLRHHQN-LPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTL 235
            |....||: .....:.|:...:| |.:|:.....||......:.:.|:                 
Mouse   960 QGQVLLSDSNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNL----------------- 1007

  Fly   236 KTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPAC----VDLAKKQG 296
             .|...:.|::.|                               .:.||...|    |.:|::  
Mouse  1008 -VRYVRVLGNMVH-------------------------------AIQIKTKLCQLVEVMMARR-- 1038

  Fly   297 TCDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNK-------- 353
              |....|           :..|.|.|.|:...|..|          |::|....:.        
Mouse  1039 --DDLSFC-----------QEMKFRNKMVEYLTDWVM----------GTSNQAADDDIKCLTRDL 1080

  Fly   354 SAGSLES--SANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNK----QEQQA 412
            ...|:|:  |...|..:.|..| |.||::     :|...:..|.|  .:.:.:||.    :::.|
Mouse  1081 DQASMEAVVSLLAGLPLQPEEG-DGVELM-----EAKSQLFLKYF--TLFMNLLNDCSEVEDENA 1137

  Fly   413 VNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRL---SVDSTIGSLR-LNLNYTADHVFPLAT 473
            ....     :.|.|:....||    |.|.....:.|   :|||  |.:. :.|.|..| :...||
Mouse  1138 QTGG-----RKRGMSRRLASL----RHCTVLAMSNLLNANVDS--GLMHSIGLGYHKD-LQTRAT 1190

  Fly   474 YDDLMNLLLES------------VDQRPITVSAVSILGEL--------------VSGKTEVAQPL 512
            :.:::..:|:.            .|:....|..|:::|:.              .|...|:|:.|
Mouse  1191 FMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVL 1255

  Fly   513 VRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQI 577
            |.||.....:..::..:...|:.......|:||||:|.||:|....::.|..||.:.|.|:|..|
Mouse  1256 VTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVI 1320

  Fly   578 VA----EKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDL----- 633
            :.    :....|:||::::...:::.|..||....|:.|.||..|:...|..|..:.|.|     
Mouse  1321 ITSSDWQHVSFEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPSQLRSVCHCLYQATC 1385

  Fly   634 ----------------RECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQT 682
                            :....:.||.|   ....|...:||||..|||:.|....:..::...:.
Mouse  1386 HSLLNKATVKERKENKKSVVSQRFPQN---SIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI 1447

  Fly   683 SRTLTLISKTIQSLGNLV------SSRSSQQTCKEEFTVELYKKF-------CTEQHVDAVKHFL 734
            .|.|.|:||.:||:.|.|      ..|......|..|  :|.::|       |...  |||.|.|
Mouse  1448 ERGLKLMSKVLQSIANHVLFTKEEHMRPFNDFVKSNF--DLARRFFLDIASDCPTS--DAVNHSL 1508

  Fly   735 EVISTPS-----------------HASSSVHPAAAAATPLEPV--LLK----------------- 763
            ..||..:                 :.||:....|....|.:.:  ||.                 
Mouse  1509 SFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSS 1573

  Fly   764 --------EGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSY--AKSKGKQPI 804
                    |..||::....|   .:||    .|.|.|:.|  ..||...||
Mouse  1574 LNLTSSKFEEFMTRHQVHEK---EEFK----ALKTLSIFYQAGTSKAGNPI 1617

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046 9/60 (15%)
C2B_RasA3 280..462 CDD:175977 41/203 (20%)
RasGAP 449..797 CDD:214617 103/458 (22%)
RasGAP_GAP1_like 473..740 CDD:213330 79/330 (24%)
PH 761..859 CDD:278594 16/71 (23%)
PH_GAP1-like 763..867 CDD:269950 14/69 (20%)
BTK 862..897 CDD:128417
Nf1XP_006532499.1 RasGAP_Neurofibromin 1210..1563 CDD:213332 83/359 (23%)
CRAL_TRIO_2 1614..1748 CDD:372686 2/4 (50%)
PH_NF1 1740..1849 CDD:270123
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R472
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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