DRSC/TRiP Functional Genomics Resources

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Protein Alignment RasGAP1 and RASA4

DIOPT Version :9

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:XP_016867150.1 Gene:RASA4 / 10156 HGNCID:23181 Length:840 Species:Homo sapiens


Alignment Length:1018 Identity:250/1018 - (24%)
Similarity:401/1018 - (39%) Gaps:286/1018 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRR 109
            |.::|.|.|||.:::..       |:.|.||.:.:|.|.|.||.|:.:||.||:|||:|..:|..
Human     7 LYIRIVEGKNLPAKDIT-------GSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64

  Fly   110 FRYLTIYLWDRD-MKQDKPIGKIAIKREELHMYNHK---DHWFSLRPVDQDSEVQGMVNVEVAFT 170
            |..:..|:.|.| :.:|..|||:.:.|:.:  .:|.   ..|..|..||.|.||||.:       
Human    65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTI--ASHPKGFSGWAHLTEVDPDEEVQGEI------- 120

  Fly   171 EAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTL 235
                                              ||                             
Human   121 ----------------------------------HL----------------------------- 122

  Fly   236 KTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK--QGTC 298
                                            :|..|.. .|...:...|....|||.|  .||.
Human   123 --------------------------------RLEVWPG-ARACRLRCSVLEARDLAPKDRNGTS 154

  Fly   299 DPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSAN 363
            ||||  ...|..:   ||.|...||:..|.::|...|:|                ..|::|:   
Human   155 DPFV--RVRYKGR---TRETSIVKKSCYPRWNETFEFEL----------------QEGAMEA--- 195

  Fly   364 KGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEV-----RLPMLNKQEQQAVNPSAWYYLQP 423
                           :.|..|.  ...:|...|||:|     ||.::.::|       .|:.|||
Human   196 ---------------LCVEAWD--WDLVSRNDFLGKVVIDVQRLRVVQQEE-------GWFRLQP 236

  Fly   424 ---RSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESV 485
               :|..|.                     :..:|||:|.:....:.|.|.:.|..|::||...|
Human   237 DQSKSRRHD---------------------EGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEV 280

  Fly   486 D---QRPITVSAVSILGELVSG--KTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFR 545
            .   |.|  ...:.::.|..|.  :.:||..|::||.........:..|...|:|..::..|:||
Human   281 KLGMQGP--GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFR 343

  Fly   546 GNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLH-------- 602
            .|:|.||.|:..::::|:.|||..|.|:::::..|||..|:||||::.:....:.||        
Human   344 SNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEV 408

  Fly   603 ------NLQDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFP--SNREVRYSVVSGFIFLR 659
                  .|:.::..:..|:::|...||.|:...|..|.....|.||  .:..|.:..|:.|:.||
Human   409 LEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLR 473

  Fly   660 FFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTE 724
            ||:|||:.||||.|.....||:|||||.|::|.:|::||:.:..|   ..||.:...|..  ...
Human   474 FFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPAS---RAKEAWMEPLQP--TVR 533

  Fly   725 QHVDAVKHFL-EVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRK--RFGRQFKQRHF 786
            |.|..:|.|: :::.........:....:...|  ||  |||.:..:.|..|  .....||:.:|
Human   534 QGVAQLKDFITKLVDIEEKDELDLQRTLSLQAP--PV--KEGPLFIHRTKGKGPLMSSSFKKLYF 594

  Fly   787 RLTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTT----NCVE 847
            .|||.:||:||:...:....|.|..|.:.|::::|||...:..::::.|.:...||.    .||.
Human   595 SLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVN 659

  Fly   848 E-REWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTAL 911
            | .:|...|.|:.:.|:..:..:||..|....:|||.:.::...||    |||..  ::.|....
Human   660 ELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGC----DKTRS--RVTLQEWN 718

  Fly   912 DPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLS------------------------------- 945
            || ||......||..::..:|::|  ...|:.||                               
Human   719 DP-LDHDLEAQLIYRHLLGVEAML--WERHRELSGGAEAGTVPTSPGKGRSCPPGTCSWPEPPPE 780

  Fly   946 -----QTQHQQHNPLVPLATDLQKHSPQ-AFAEFKRTIEKLRE 982
                 ...|.|....:||.|     .|: :.|...|.::.|||
Human   781 MHGWGPRAHSQGPSRLPLPT-----VPEDSLARLLRVLQDLRE 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046 44/127 (35%)
C2B_RasA3 280..462 CDD:175977 43/191 (23%)
RasGAP 449..797 CDD:214617 109/371 (29%)
RasGAP_GAP1_like 473..740 CDD:213330 87/288 (30%)
PH 761..859 CDD:278594 31/104 (30%)
PH_GAP1-like 763..867 CDD:269950 32/110 (29%)
BTK 862..897 CDD:128417 9/34 (26%)
RASA4XP_016867150.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144461
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D145372at2759
OrthoFinder 1 1.000 - - FOG0000825
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10194
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

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