Protein Alignment RasGAP1 and rasal2

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: XP_004914087.1
• Gene: rasal2 / 100379974
• XenbaseID: XB-GENE-5795955
• Length: 1279
• Species: Xenopus tropicalis
• Alignment Length: 1160
• Identity: 252/1160 - (21%)
• Similarity: 423/1160 - (36%)
• Gaps: 288/1160 - (24%)

  Fly   153 VDQDSEVQGMVNVEVAF---TEAQQTQSLSEGIDL---GQHTLRHHQNLPHHSHQQRAHLNDYKE 211
            :::|.|:.|    |.|.   .|:.:::||...:.:   ||        .|.:..:..|.|....|
 Frog    96 LNRDDEMPG----ETAQDPPPESSKSRSLRRTVSVPSEGQ--------FPDYPPEGAAKLEVPAE 148

  Fly   212 NSELSNIQRASAAAASSS------SAAMTLKTRAAGLF-----GHVHHPPSQTQ-----HFPIIN 260
            .|.    :|.|.:..|:|      ..|.|...:.:|.|     |.:....||::     .|.:.:
 Frog   149 RSP----RRRSISGTSTSDKTNAMDPANTSPFKVSGFFSKRLKGSIKRTKSQSKLDRNTSFRLPS 209

  Fly   261 TTSTSSD------QLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAH------------ 307
            .....||      :|...:||...:.....|.| :||    ||.|..:|...|
 Frog   210 LRPAESDRSRGLPKLKESRSHESLLSPGSAVEA-LDL----GTEDKILVKPLHSSILGQDFCFEV 269

  Fly   308 -YSNKHQ------VTRRTK---QRKKTVDPEFD---------------------EAMYF-DLHID 340
             ||:..:      ...|.|   ..::||.|..|                     :..|| :|.:|
 Frog   270 TYSSGSKCFSCSSAAERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLD 334

  Fly   341 ADAGSTNTTGSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAH-GAMSDK-VFLGEVRLP 403
             |.....||...|:.........:.|.:.|     |..|.|.::.|.. ....|| .::|.|.:|
 Frog   335 -DTLFARTTSKTKADNIFWGEYFEFYGLPP-----LHNITVHIYKDVEKKKKKDKNNYVGLVNIP 393

  Fly   404 MLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIG-SLRLNLNYTADH 467
            |::...:|.|  ..||                   ..:||...:   ..|:| |:|:...|....
 Frog   394 MISVTGRQFV--EKWY-------------------PVSTPTANK---GKTVGPSIRIKSRYQTIT 434

  Fly   468 VFPLATYDDLMNLLLESVDQRPITVS---AVSILGELVS--GKTEVAQPLVRLFTHTERIAPIIK 527
            :.|:..|.:....         ||::   ..|:|..::|  .|.|:|..||.:...|.|....:.
 Frog   435 ILPMEQYKEFAEF---------ITINYTMLCSVLEPVISVRNKEEMACALVHILQSTGRAKDFLT 490

  Fly   528 ALADHEISHLTD-PTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKI 591
            .|...|:....: ...|||.|||.:|.::|.::|.|..|||..|...:..:....:.||:||||.
 Frog   491 DLVMSEVDRCGEHDVLIFRENTLATKAIEEYLKLVGQKYLHDALGEFIKALYESDENCEVDPSKC 555

  Fly   592 KDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREVRYSVVSGF 655
            .. |.:..:..||:...|..|..|..|....|:.|.::|...: :|...   ..:::...::|..
 Frog   556 SS-SELSDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCINR---GKQDISERLISAS 616

  Fly   656 IFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKK 720
            :||||..|||:.|.||.|..|..|.:||||||||:|.||:|.|.....:     |||:..  :..
 Frog   617 LFLRFLCPAIMSPSLFGLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN-----KEEYMA--FMN 674

  Fly   721 FCTEQHVDAVKHFLEVISTPSHAS----------------------------------SSVHPAA 751
            ...|.....:|.||:.||.|...|                                  |.:....
 Frog   675 DFLEHEWGGMKRFLQEISNPDTISNTPGFEGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATV 739

  Fly   752 AAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAKSKGKQPICDIP----LQEI 812
            ....||..:|..   :||..|:.....:|.::.....:|.::|.:.|.|.|.|.:.|    ||..
 Frog   740 EKLGPLPRILAD---ITKSLTNPTPIQQQLRRFSEHSSTPNVSGSLSSGLQKIFEDPADSDLQRF 801

  Fly   813 AS-----------------VEQLKDKSF------KMQNCF--------------KIVHNDRSLIV 840
            .|                 |:|...:|.      :.:|..              .:.|.|||.::
 Frog   802 RSPTIENPESYFRGKTLLLVQQASTQSMSFSDKDERENVLPNGRSVSLMDLQDSNVSHTDRSSVI 866

  Fly   841 QTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQM 905
            |............:.| :..:..:|..:..|               :::|..:|.|...:..
 Frog   867 QEPPLRLTGSQLSIAH-VATIKQLRENHSMP---------------QSAPQVRKPLHPALSQ--- 912

  Fly   906 DLVTALDPALDLQRIHTL-----IMSNMSVLESLLDPLTYHQSLSQTQHQQ---HNPLVPLATDL 962
              .::|.|......::.|     .|...|| :|.|:.|:...|.||:..::   ..|......|.
 Frog   913 --QSSLQPLSFQNPVYHLNNPPPTMPKASV-DSSLENLSTASSRSQSNSEEFILSGPSNSSMEDF 974

  Fly   963 QKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGI--TRQLKYGSR-QAPIGDDNYWH--MMRA 1022
            .|.|.|:....:|.....|....|:.|.:...:..|  |.|...|:| :||   .:..|  .:|:
 Frog   975 TKRSTQSEDFTRRHTMPERPIPIALPRQNSTGQAQIRKTDQAALGARAKAP---QSLPHSASLRS 1036

  Fly  1023 AGQLN--QQHHQQQQHQQQQQQQQQQQLQQFQPQPVL-----PQMQNVRAYPYQPAT----SNMN 1076
            ||.::  ..:...:..|...:.:||....:..|.|.|     .|.|.|:: |...||    ....
 Frog  1037 AGSMSGISNNMLVEPVQNGNRSRQQSTSSRESPVPKLRAIHRQQTQQVQS-PVDSATMSPVERTA 1100

  Fly  1077 AYCLHNMQYQQQRLPFHQQQ------QQHHQQLQQQQSQFQPLRSHQLQRHNNNL 1125
            |:.|:|.||:.:.....|.:      :::.|::.:.:.:.: :.|.:|:.:...|
 Frog  1101 AWVLNNGQYEDEEETVDQNKDESKPAEKYEQEIAKLKERLK-ISSRRLEEYERRL 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	4/15 (27%)
		C2B_RasA3	280..462	CDD:175977	47/228 (21%)
		RasGAP_GAP1_like	473..740	CDD:213330	82/273 (30%)
		PH_GAP1-like	763..867	CDD:269950	25/144 (17%)
		BTK	862..897	CDD:128417	4/34 (12%)
rasal2	XP_004914087.1	PH-like	173..357	CDD:473070	37/189 (20%)
		C2_SynGAP_like	299..438	CDD:175980	33/168 (20%)
		RasGAP_DAB2IP	429..759	CDD:213338	93/352 (26%)
		DUF3498	749..1250	CDD:463427	84/436 (19%)