DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and rasal2

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	XP_004914087.1	Gene:	rasal2 / 100379974	XenbaseID:	XB-GENE-5795955	Length:	1279	Species:	Xenopus tropicalis

Alignment Length:	1160	Identity:	252/1160 - (21%)
Similarity:	423/1160 - (36%)	Gaps:	288/1160 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 VDQDSEVQGMVNVEVAF---TEAQQTQSLSEGIDL---GQHTLRHHQNLPHHSHQQRAHLNDYKE 211
            :::|.|:.|    |.|.   .|:.:::||...:.:   ||        .|.:..:..|.|....|
Frog    96 LNRDDEMPG----ETAQDPPPESSKSRSLRRTVSVPSEGQ--------FPDYPPEGAAKLEVPAE 148

  Fly   212 NSELSNIQRASAAAASSS------SAAMTLKTRAAGLF-----GHVHHPPSQTQ-----HFPIIN 260
            .|.    :|.|.:..|:|      ..|.|...:.:|.|     |.:....||::     .|.:.:
Frog   149 RSP----RRRSISGTSTSDKTNAMDPANTSPFKVSGFFSKRLKGSIKRTKSQSKLDRNTSFRLPS 209

  Fly   261 TTSTSSD------QLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAH------------ 307
            .....||      :|...:||...:.....|.| :||    ||.|..:|...|
Frog   210 LRPAESDRSRGLPKLKESRSHESLLSPGSAVEA-LDL----GTEDKILVKPLHSSILGQDFCFEV 269

  Fly   308 -YSNKHQ------VTRRTK---QRKKTVDPEFD---------------------EAMYF-DLHID 340
             ||:..:      ...|.|   ..::||.|..|                     :..|| :|.:|
Frog   270 TYSSGSKCFSCSSAAERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLD 334

  Fly   341 ADAGSTNTTGSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAH-GAMSDK-VFLGEVRLP 403
             |.....||...|:.........:.|.:.|     |..|.|.::.|.. ....|| .::|.|.:|
Frog   335 -DTLFARTTSKTKADNIFWGEYFEFYGLPP-----LHNITVHIYKDVEKKKKKDKNNYVGLVNIP 393

  Fly   404 MLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIG-SLRLNLNYTADH 467
            |::...:|.|  ..||                   ..:||...:   ..|:| |:|:...|....
Frog   394 MISVTGRQFV--EKWY-------------------PVSTPTANK---GKTVGPSIRIKSRYQTIT 434

  Fly   468 VFPLATYDDLMNLLLESVDQRPITVS---AVSILGELVS--GKTEVAQPLVRLFTHTERIAPIIK 527
            :.|:..|.:....         ||::   ..|:|..::|  .|.|:|..||.:...|.|....:.
Frog   435 ILPMEQYKEFAEF---------ITINYTMLCSVLEPVISVRNKEEMACALVHILQSTGRAKDFLT 490

  Fly   528 ALADHEISHLTD-PTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKI 591
            .|...|:....: ...|||.|||.:|.::|.::|.|..|||..|...:..:....:.||:||||.
Frog   491 DLVMSEVDRCGEHDVLIFRENTLATKAIEEYLKLVGQKYLHDALGEFIKALYESDENCEVDPSKC 555

  Fly   592 KDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREVRYSVVSGF 655
            .. |.:..:..||:...|..|..|..|....|:.|.::|...: :|...   ..:::...::|..
Frog   556 SS-SELSDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCINR---GKQDISERLISAS 616

  Fly   656 IFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKK 720
            :||||..|||:.|.||.|..|..|.:||||||||:|.||:|.|.....:     |||:..  :..
Frog   617 LFLRFLCPAIMSPSLFGLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN-----KEEYMA--FMN 674

  Fly   721 FCTEQHVDAVKHFLEVISTPSHAS----------------------------------SSVHPAA 751
            ...|.....:|.||:.||.|...|                                  |.:....
Frog   675 DFLEHEWGGMKRFLQEISNPDTISNTPGFEGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATV 739

  Fly   752 AAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAKSKGKQPICDIP----LQEI 812
            ....||..:|..   :||..|:.....:|.::.....:|.::|.:.|.|.|.|.:.|    ||..
Frog   740 EKLGPLPRILAD---ITKSLTNPTPIQQQLRRFSEHSSTPNVSGSLSSGLQKIFEDPADSDLQRF 801

  Fly   813 AS-----------------VEQLKDKSF------KMQNCF--------------KIVHNDRSLIV 840
            .|                 |:|...:|.      :.:|..              .:.|.|||.::
Frog   802 RSPTIENPESYFRGKTLLLVQQASTQSMSFSDKDERENVLPNGRSVSLMDLQDSNVSHTDRSSVI 866

  Fly   841 QTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQM 905
            |............:.| :..:..:|..:..|               :::|..:|.|...:..
Frog   867 QEPPLRLTGSQLSIAH-VATIKQLRENHSMP---------------QSAPQVRKPLHPALSQ--- 912

  Fly   906 DLVTALDPALDLQRIHTL-----IMSNMSVLESLLDPLTYHQSLSQTQHQQ---HNPLVPLATDL 962
              .::|.|......::.|     .|...|| :|.|:.|:...|.||:..::   ..|......|.
Frog   913 --QSSLQPLSFQNPVYHLNNPPPTMPKASV-DSSLENLSTASSRSQSNSEEFILSGPSNSSMEDF 974

  Fly   963 QKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGI--TRQLKYGSR-QAPIGDDNYWH--MMRA 1022
            .|.|.|:....:|.....|....|:.|.:...:..|  |.|...|:| :||   .:..|  .:|:
Frog   975 TKRSTQSEDFTRRHTMPERPIPIALPRQNSTGQAQIRKTDQAALGARAKAP---QSLPHSASLRS 1036

  Fly  1023 AGQLN--QQHHQQQQHQQQQQQQQQQQLQQFQPQPVL-----PQMQNVRAYPYQPAT----SNMN 1076
            ||.::  ..:...:..|...:.:||....:..|.|.|     .|.|.|:: |...||    ....
Frog  1037 AGSMSGISNNMLVEPVQNGNRSRQQSTSSRESPVPKLRAIHRQQTQQVQS-PVDSATMSPVERTA 1100

  Fly  1077 AYCLHNMQYQQQRLPFHQQQ------QQHHQQLQQQQSQFQPLRSHQLQRHNNNL 1125
            |:.|:|.||:.:.....|.:      :::.|::.:.:.:.: :.|.:|:.:...|
Frog  1101 AWVLNNGQYEDEEETVDQNKDESKPAEKYEQEIAKLKERLK-ISSRRLEEYERRL 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	4/15 (27%)
		C2B_RasA3	280..462	CDD:175977	47/228 (21%)
		RasGAP	449..797	CDD:214617	100/389 (26%)
		RasGAP_GAP1_like	473..740	CDD:213330	82/273 (30%)
		PH	761..859	CDD:278594	25/138 (18%)
		PH_GAP1-like	763..867	CDD:269950	25/144 (17%)
		BTK	862..897	CDD:128417	4/34 (12%)
rasal2	XP_004914087.1	PH-like	173..357	CDD:388408	37/189 (20%)
		C2_SynGAP_like	299..438	CDD:175980	33/168 (20%)
		RasGAP_DAB2IP	429..759	CDD:213338	93/352 (26%)
		DUF3498	749..1241	CDD:371844	84/436 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000