DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and rasa2

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	XP_017207610.1	Gene:	rasa2 / 100331895	ZFINID:	ZDB-GENE-030131-5660	Length:	823	Species:	Danio rerio

Alignment Length:	991	Identity:	318/991 - (32%)
Similarity:	494/991 - (49%)	Gaps:	191/991 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DTREVRIEEQLKVKIGEAKNLSSRNAANTSCSTQGTRDV--YCTIALDQEEICRTPTIERTLTPF 97
            |..::||.:.|:.||.|||:|...:..|.      .||:  :|||:|||||:.||...|::::||
Zfish     5 DDTKIRILQSLRGKICEAKHLGPNSGPNR------LRDLCTFCTISLDQEEVYRTKVFEKSVSPF 63

  Fly    98 FGEEHQFKIPRRFRYLTIYLWDRDMKQ--DKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQ 160
            :.|:..|:|||.|:.|:.|::.:.|.|  |.|:||:||::|:|:.|..|::||.|:|||..||||
Zfish    64 YSEDFYFEIPRPFQCLSFYVYAKSMFQIRDLPVGKVAIRKEDLYKYCGKENWFQLQPVDPHSEVQ 128

  Fly   161 GMVNVEVAFTEAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAA 225
            |.|::|:...|
Zfish   129 GKVHLEMKLNE------------------------------------------------------ 139

  Fly   226 ASSSSAAMTLKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVD 290
                                            :|....:...||            .:::.||..
Zfish   140 --------------------------------LITENGSICQQL------------VVQIIACQG 160

  Fly   291 LAKKQG-TCDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKS 354
            |....| .|||:...|.....:.. .::||.:|||.||:|||..:|::
Zfish   161 LPLISGQNCDPYATVTLVGPTRSD-QKKTKVKKKTSDPQFDETFHFEV----------------- 207

  Fly   355 AGSLESSANKGYSIYPVGGADL--VEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSA 417
               ..||:.||.|.:.|...|:  :||.|.:|:  :|.::..|||||.|:.:...:....  ..|
Zfish   208 ---TRSSSYKGRSQFHVEEEDIEKLEIKVELWN--NGNLAQDVFLGETRVSVKILRNDHV--HRA 265

  Fly   418 WYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLL 482
            ||.|||:.                  .||:...|. :|||||.:.||.|:|.|.|.|..|.||:|
Zfish   266 WYLLQPKG------------------NGTKSKPDD-LGSLRLKVTYTEDNVLPSACYTALRNLML 311

  Fly   483 ESVDQRPITVSAVSILGELVSGKT--EVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFR 545
            :|.|.:||:.||..:||::.....  :...|:|||..|..|:.|.:.|:|..|:.:..:..||||
Zfish   312 KSPDVKPISASAAHVLGDICREGVGYDALLPVVRLLLHHNRLLPFLTAVAALELENTQEANTIFR 376

  Fly   546 GNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVER 610
            ||:|.::.:|:.|::.|..||..||:|||::|....|.|||||.|:|:...|:.|..|||.||::
Zfish   377 GNSLATRCIDDMMKIVGRSYLTVTLKPVLNEIFESIKTCEIDPVKLKEGDNVEVNKENLQGYVQK 441

  Fly   611 VFEAITKSADRCPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTT 675
            ||.:||:|:..||.::|.:|..||:.|.:.||::..|:||.||.||||||||.|:|.|..|.|.:
Zfish   442 VFTSITQSSSSCPPLMCDVFRSLRQLASKRFPADPHVQYSAVSSFIFLRFFAVAVLSPHTFQLRS 506

  Fly   676 ERLDAQTSRTLTLISKTIQSLGNLVS-SRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFL-EVIS 738
            ...|.:.|||||||||||||||:..| |::...:.||.|..:.:|.|..::.::.||.|| |:.|
Zfish   507 HHPDPEISRTLTLISKTIQSLGSWGSLSKNKLSSFKETFMCDFFKLFQEDECIEKVKKFLDEISS 571

  Fly   739 TPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQ-FKQRHFRLTTHSLSYAKSKGKQ 802
            ..|..||.|.         :..:||||.:.|....:||.|:: ||:|..|:|...|||.|.|||:
Zfish   572 NVSKESSGVE---------DSFVLKEGEIHKRAQGKKRIGKKNFKKRWLRVTNQELSYHKQKGKE 627

  Fly   803 PICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQ 867
            .:|.||::.|..:|:|::.:|..:|.|:::|:::.|.||.:||||...|.::|.::...|..|:.
Zfish   628 ALCVIPVKHILGIEKLEESAFNRKNMFQVIHSEKPLYVQASNCVETNSWIEVLSQVSRCNPGRLS 692

  Fly   868 YFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLE 932
            .||.||:|.|.:.||...:|::||||......:...|:|    :|...:.:||.:...:..|.|:
Zfish   693 TFHLSAYVGGSWLCCKEPNESAPGCKPCTATVLANIQLD----IDCDRETERIFSFFSTYRSRLQ 753

  Fly   933 SLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAID--RDHRDYK 995
            .:.|...   .:|....||           ::.|.....:.|.|...::|....:|  :.|.|.|
Zfish   754 KMEDVCA---GMSVYLGQQ-----------EECSAFTIQDPKETFRTIKELGEVLDELQSHHDSK 804

  Fly   996 QGITRQLKYGSRQAPI 1011
            ..:|.:  .|:.:.||
Zfish   805 GALTDE--PGTIENPI 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	56/128 (44%)
		C2B_RasA3	280..462	CDD:175977	51/184 (28%)
		RasGAP	449..797	CDD:214617	149/352 (42%)
		RasGAP_GAP1_like	473..740	CDD:213330	117/270 (43%)
		PH	761..859	CDD:278594	39/98 (40%)
		PH_GAP1-like	763..867	CDD:269950	40/104 (38%)
		BTK	862..897	CDD:128417	15/34 (44%)
rasa2	XP_017207610.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577569
Domainoid	1	1.000	116	1.000	Domainoid score	I5923
eggNOG	1	0.900	-	-		E1_KOG2059
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	629	1.000	Inparanoid score	I830
OMA	1	1.010	-	-		QHG49607
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0000825
OrthoInspector	1	1.000	-	-		otm25903
orthoMCL	1	0.900	-	-		OOG6_104099
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R472
SonicParanoid	1	1.000	-	-		X2711
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800