DRSC/TRiP Functional Genomics Resources

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Protein Alignment RasGAP1 and syngap1b

DIOPT Version :9

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:NP_001313396.1 Gene:syngap1b / 100151149 ZFINID:ZDB-GENE-100921-2 Length:1507 Species:Danio rerio


Alignment Length:1157 Identity:258/1157 - (22%)
Similarity:396/1157 - (34%) Gaps:342/1157 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 HQNLP--HHSHQQRAHL-NDYKENSELSNIQRASAAAASSSSAAMTLKTRAAGLFGHVHHP-PSQ 252
            |..||  ..:.|:|..| ..:||:.     ...|..:.||::.|:.|......:...||.. ..|
Zfish   242 HMILPRFRSADQERTRLMQSFKESH-----SHESLLSPSSAAEALDLTLDEDAIIKPVHSSILGQ 301

  Fly   253 TQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHYSNKHQVTRR 317
            ...|.:|..:.|                   |..||...|::    |.::      .|..:..:.
Zfish   302 EYCFEVITASGT-------------------KCFACRSAAER----DKWI------ENLQRAVKP 337

  Fly   318 TKQRKKTVD--------------PEFDEAMYFDLHIDADAGSTNTT----------GSNKSAGSL 358
            .|...:.||              |:  :..|.:|.:| |.....||          |.:....:|
Zfish   338 NKDNSRRVDNVLKLWIIEARELPPK--KRYYCELCLD-DMLYARTTSKPRTDTVFWGEHFEFNNL 399

  Fly   359 ESSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWY-YLQ 422
            .:..|....:|..             .|.........:||.|.:|:.:...:|.|  ..|| .:|
Zfish   400 PAVRNLRLHLYKE-------------TDKKRRKEKSTYLGLVSIPISSITGRQFV--EQWYPVIQ 449

  Fly   423 PRSMTH-----SSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLL 482
            |..:..     ..:.:||                    ||||...:....:.|:..|.:    ..
Zfish   450 PSVLAKGGGVGGGKIINA--------------------SLRLKSRFQTMSILPMELYKE----FA 490

  Fly   483 ESVDQRPITVSAVSILGELVS--GKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTD-PTTIF 544
            |.|.....|:.||  |..|:|  .|.|||..||.:...|.:....:..:|..|:....| ...||
Zfish   491 EYVTNNYRTLCAV--LEPLLSVKSKEEVACALVHILQSTGKAKDFLSDMAMCEVDRFIDREHLIF 553

  Fly   545 RGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVE 609
            |.|||.:|.::|.::|.|..||...|...:..:...::.||:||.:... |.:..:..||:...|
Zfish   554 RENTLATKAIEEYLKLIGHKYLKDVLGDFIRALYESEENCEVDPMRTPP-SILPEHQANLRMCCE 617

  Fly   610 RVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDL 673
            .....|..|....|:.|.::|...| .||..   ...::...::||.:||||..|||:.|.||:|
Zfish   618 LALCKIINSYCAFPRELKEVFASWRVRCAER---GREDIADRLISGSLFLRFLCPAIMSPSLFNL 679

  Fly   674 TTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVIS 738
            |.|..|.|||||||||:|.:|:|.|.     |:...|||:.  .:.....|....:::.||..||
Zfish   680 TQEYPDEQTSRTLTLIAKVVQNLANF-----SKFGSKEEYM--CFMNEFLEMEWGSMQQFLYEIS 737

  Fly   739 TPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAKSK---- 799
            .    ..||..|.|.          ||.:.        .||:....|..|.......:||.    
Zfish   738 N----LDSVSNAGAF----------EGYID--------LGRELSILHSLLWEVMAQLSKSSIRSW 780

  Fly   800 ---GKQPICDI-PLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICL 860
               .|..|..: ||..:     |.|.|..::|    .|..|....||.....||:...||.:   
Zfish   781 FIVSKDAIIKLGPLPRL-----LNDISMALRN----PHLQRQPSHQTDRQPAERQTDRLLSR--- 833

  Fly   861 MNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRI--HTL 923
                      || |..|..|                     .||..::..|:.::::.|:  .|.
Zfish   834 ----------PS-FNRGVSS---------------------EFQNLMMRDLNSSVEITRLPSPTS 866

  Fly   924 IMS------NMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLRE 982
            .||      :.:.:....|....|::.|:.......|  |||    :.|| |:......|     
Zfish   867 AMSSGGAPPSRAGMAGFADRDHPHRASSKDVFYGARP--PLA----RSSP-AYCTSSSDI----- 919

  Fly   983 KAYAIDRDHRDYKQGITRQLK-----YGSRQAPI-GDDNYWHM----------MRAAG------- 1024
                .|.|.:|.:......|:     ..|.||.| |..:|..:          :||.|       
Zfish   920 ----TDPDPKDSRMNSVSNLQSMGDMLNSSQASIAGLGSYGGLAGLGGGLGGQLRAGGRMSAGSG 980

  Fly  1025 -----------QLNQQHHQQQQHQQQQQQQQ-----------------------QQQLQQFQPQP 1055
                       ||:|.........||||||.                       ..|..:.||.|
Zfish   981 GSSMSGGLRLSQLSQMGTTTDSLSQQQQQQAAALRFPLSFQNPLFHLAADGPQLHHQHSRAQPPP 1045

  Fly  1056 VL--------------PQ-----------MQNVRAYPY--QPAT----SNMNAYCLHNM-QYQQQ 1088
            .|              ||           :..:|..|:  ||:.    |..:.|..||. .|.::
Zfish  1046 PLLLAPEPDGSHPTYIPQFAHGGFSRSEDLSTLRPGPHLGQPSIIHSHSYSDDYSRHNQSDYGRR 1110

  Fly  1089 RLPFHQQQQQH-----------HQQLQQQQSQFQPLRSHQL----QRHNNNLNNNNCGNGSSSSP 1138
            ::..|.|:||.           |..|....|..||:|...:    ||..:..::....:.::.:|
Zfish  1111 QISMHMQEQQQMAGMASQTGTSHSSLATPPSTVQPVRQSSMAPPTQRMKSQPSHQLSVSSAAGAP 1175

  Fly  1139 SSTT----SSVVAAPPSTTSSSQPAPPIYXRSRLCVF-----ALPRAIITTR 1181
            :|.|    .:::.:|.|.....|..|    |.:|.|.     .||....:||
Zfish  1176 ASKTRPQSGNLLQSPESGFGGRQQGP----RQQLSVKDSTPPGLPHQQSSTR 1223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046
C2B_RasA3 280..462 CDD:175977 37/211 (18%)
RasGAP 449..797 CDD:214617 101/351 (29%)
RasGAP_GAP1_like 473..740 CDD:213330 86/270 (32%)
PH 761..859 CDD:278594 24/105 (23%)
PH_GAP1-like 763..867 CDD:269950 24/111 (22%)
BTK 862..897 CDD:128417 5/34 (15%)
syngap1bNP_001313396.1 PH-like 208..395 CDD:302622 36/189 (19%)
C2_SynGAP_like 337..483 CDD:175980 31/183 (17%)
RasGAP 463..809 CDD:214617 113/413 (27%)
RasGAP_DAB2IP 474..808 CDD:213338 107/381 (28%)
DUF3498 798..1430 CDD:288827 99/485 (20%)
Muted <1298..1389 CDD:291603
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170577572
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.840

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