DRSC/TRiP Functional Genomics Resources

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Protein Alignment RasGAP1 and rasa3

DIOPT Version :9

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:XP_004911857.1 Gene:rasa3 / 100144662 XenbaseID:XB-GENE-920756 Length:834 Species:Xenopus tropicalis


Alignment Length:992 Identity:351/992 - (35%)
Similarity:531/992 - (53%) Gaps:172/992 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 VRIEEQLKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQ 103
            :|:.:.:|:||||||||.|....|.      .||.:||:.|||||:.||..:|::|.||:||:..
 Frog     8 IRVFQSVKIKIGEAKNLPSYPGPNK------MRDCFCTVNLDQEEVFRTKIVEKSLCPFYGEDFY 66

  Fly   104 FKIPRRFRYLTIYLWDRDM-KQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEV 167
            .:|||.||:|:.|::|||: ::|..:||::|.:|:|..||::|.||.::.||.||||||.|::|:
 Frog    67 CEIPRSFRHLSFYIFDRDVFRRDSIMGKVSILKEDLQQYNNRDTWFQVQHVDADSEVQGKVHLEL 131

  Fly   168 AFTEAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAA 232
                     .|||.|                                             :.|..
 Frog   132 ---------RLSEVI---------------------------------------------TDSGV 142

  Fly   233 MTLKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGT 297
            :..|..|..|         :.|..||:|                                   |.
 Frog   143 ICHKLLARVL---------ECQGLPIVN-----------------------------------GQ 163

  Fly   298 CDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSA 362
            |||:...|....::.: .::||.||||.:|:|||..||::        |.....||         
 Frog   164 CDPYATVTLLGPSRSE-AKKTKVRKKTNNPQFDEVFYFEV--------TKPCSYNK--------- 210

  Fly   363 NKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMT 427
             |.:........|.:||.|.:|:.::....|: ||||:::|:  |..:|:....|||:||||.  
 Frog   211 -KSHFEIEEDDVDKLEIRVDLWNASNLKFGDE-FLGELKIPL--KVLRQSSCHGAWYFLQPRD-- 269

  Fly   428 HSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITV 492
                            .|..:..|. :||||||:.||.|||||...|..|.:|:|:|.|..|::.
 Frog   270 ----------------NGKSVKPDD-LGSLRLNVVYTEDHVFPSEYYSPLRDLVLKSGDVEPVSA 317

  Fly   493 SAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEA 557
            ||..:|||:...|.|.|.||||||.|..:|.|.|.|:|:.|::...||.||||||:|.||.:||.
 Frog   318 SAAHVLGEVCREKQEAAIPLVRLFLHYGKIVPFISAIANAEVNRTQDPNTIFRGNSLTSKCIDET 382

  Fly   558 MRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRC 622
            |:|:|:|||..||:|::.:|....|||||||.|:||....:.|..||::||:|:|:.||||...|
 Frog   383 MKLAGMHYLQVTLKPIIDEICEAHKPCEIDPVKLKDGENFENNKENLKNYVDRIFDVITKSGVSC 447

  Fly   623 PKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLT 687
            |.|:|.||..|||.|.:.|..:.:||::.||.||||||||||||.|.||.|:....|.|||||||
 Frog   448 PTVMCDIFFSLRESAAKRFQGDPDVRFTAVSSFIFLRFFAPAILSPNLFQLSPHHPDPQTSRTLT 512

  Fly   688 LISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPAAA 752
            |||||||:||:|  |:|...:.||.:....|:.|..:::.||||:||::||:.....   |....
 Frog   513 LISKTIQTLGSL--SKSKSASFKENYMAAFYENFNEQKYADAVKNFLDLISSSGRRD---HKRIE 572

  Fly   753 AATPLEPVLLKEGLMTKYPTSRKRFG-RQFKQRHFRLTTHSLSYAKSK-GKQPICDIPLQEIASV 815
                 :|:|||||.|.|....||||| :.||:|.||||.|..:|.||| |..|:|.||::.|.:|
 Frog   573 -----QPILLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKAGDHPLCSIPIENILAV 632

  Fly   816 EQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFYS 880
            |:|:::||||:|.|:::...|:|.:|..||||.::|.|:|.|:...|..|:..:||||:::..:.
 Frog   633 EKLEEESFKMKNMFQVIQPVRTLYIQANNCVEAKDWIDILTKVSQCNKKRLTVYHPSAYLNAHWL 697

  Fly   881 CCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLS 945
            ||..:.||:|||...........|:|    :|...:.:||::|..:.:..||.:.:.........
 Frog   698 CCKATSENAPGCTPCTGGLPANIQLD----IDGDRETERIYSLFNTYICKLEKMQEACGSKSVYD 758

  Fly   946 QTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAP 1010
            ..:.::::..:       ...|:   |..:|:.::.:....::::|..||:...::.||||::.|
 Frog   759 GPEQEEYSTFL-------IDEPR---ETYKTLYQIIDGVKTLEQEHAQYKRDKFKKTKYGSQEHP 813

  Fly  1011 IGDDNYWHMMRAAGQLN 1027
            |||.::...:|...:::
 Frog   814 IGDKSFQSYIRQQSEVS 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046 59/125 (47%)
C2B_RasA3 280..462 CDD:175977 49/181 (27%)
RasGAP 449..797 CDD:214617 172/348 (49%)
RasGAP_GAP1_like 473..740 CDD:213330 135/266 (51%)
PH 761..859 CDD:278594 50/99 (51%)
PH_GAP1-like 763..867 CDD:269950 50/105 (48%)
BTK 862..897 CDD:128417 13/34 (38%)
rasa3XP_004911857.1 C2A_RasA2_RasA3 13..133 CDD:176046 59/134 (44%)
C2B_RasA3 146..287 CDD:175977 56/225 (25%)
RasGAP_RASA3 296..564 CDD:213336 135/269 (50%)
PH_GAP1_mammal-like 561..686 CDD:241522 55/132 (42%)
BTK 679..714 CDD:128417 13/34 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 119 1.000 Domainoid score I5733
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H7217
Inparanoid 1 1.050 622 1.000 Inparanoid score I862
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D145372at2759
OrthoFinder 1 1.000 - - FOG0000825
OrthoInspector 1 1.000 - - otm48987
Panther 1 1.100 - - LDO PTHR10194
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2711
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
99.160

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