DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RasGAP1 and syngap1

DIOPT Version :9

Sequence 1:	NP_001261664.1	Gene:	RasGAP1 / 39158	FlyBaseID:	FBgn0004390	Length:	1181	Species:	Drosophila melanogaster
Sequence 2:	XP_031748229.1	Gene:	syngap1 / 100038210	XenbaseID:	XB-GENE-487270	Length:	1222	Species:	Xenopus tropicalis

Alignment Length:	1293	Identity:	254/1293 - (19%)
Similarity:	431/1293 - (33%)	Gaps:	382/1293 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 YCTIA------LDQEEI------------CRTPTIERTLT-PFFG---EEHQFKIPRRFRYLTIY 116
            ||.::      ||:||:            .||..:.||:: |..|   :||.:.:.
Frog    34 YCVLSGNQLLMLDEEEVHPLLIRERRTDPTRTKFLRRTVSVPVEGKQPDEHDYHLA--------- 89

  Fly   117 LWDRDMKQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEVAFTEAQQTQSLSEG 181
               |..::..|.|              |.......|.......||.::..:. :..::|:|..:
Frog    90 ---RSRRKSVPGG--------------KQPSMDAPPTAPFRPSQGFLSRRLK-SSIKRTKSQPK- 135

  Fly   182 IDLGQHTLRHHQNLPHH---SHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAAGLF 243
            :|   .|....|.||..   .|.:...:..:||:.     ...|..:.||::.|:.|......:.
Frog   136 LD---RTSSFRQILPRFRSADHDRARLMQAFKESH-----SHESLLSPSSAAEALDLNLDEDSVV 192

  Fly   244 GHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHY 308
            ..| |.....|.|....|||:.:                 |..||...|::    |.::
Frog   193 KPV-HSSILGQEFCFEVTTSSGT-----------------KCFACRSAAER----DKWI------ 229

  Fly   309 SNKHQVTRRTKQRKKTVD--------------PEFDEAMYFDLHIDADAGSTNTT---------- 349
            .|..:..:..|...:.||              |:  :..|.:|.:| |.....||
Frog   230 ENLQRAVKPNKDNSRRVDNVLKLWIIEARDLPPK--KRYYCELCLD-DILYARTTSKPRNDTVFW 291

  Fly   350 GSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVN 414
            |.:....:|.:..|....:|    .|.         |.........::|.|.:|:.:...:..|
Frog   292 GEHFEFNNLPAVRNLRLHLY----KDT---------DKKRRKEKSNYVGMVNVPIASISGRHFV- 342

  Fly   415 PSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMN 479
             ..||   |.|...|.:..::.|                  |:||...|....:.|:..|.:...
Frog   343 -EQWY---PVSQPTSYKGKSSCP------------------SIRLKSRYQTMSILPMELYKEFAE 385

  Fly   480 LLLESVDQRPITVSAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTD-PTTI 543
            .:..  :.|.:......:|.  |..|.|||..||.:...|.:....:..:|..|:....| ...|
Frog   386 YVTN--NYRMLCAVLEPVLS--VKSKEEVACALVHILQSTGKAKDFLSDMAMTEVDRFLDREHLI 446

  Fly   544 FRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYV 608
            .|.|||.:|.::|.::|.|..||.:.:...:..:...::.||:||.:... ||:..:..||:...
Frog   447 LRENTLATKAIEEYLKLIGQRYLKEAIGEFIRALYESEEDCEVDPMRCPP-SALPDHQANLRMCC 510

  Fly   609 ERVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFD 672
            |.....:..|....|:.|.::|...| .||..   ...::...::|..:||||..|||:.|.||.
Frog   511 ELALCKVFNSHCVFPRELKEVFASWRMRCAER---GREDIADRLISASLFLRFLCPAIMSPSLFS 572

  Fly   673 LTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVI 737
            |..|..|.|||||||||:|.||:|.|.....||    |||: :....:| .|..:..:::||..|
Frog   573 LMQEYPDEQTSRTLTLIAKVIQNLANFNYKFSS----KEEY-MSFMNEF-LETELANMQNFLYEI 631

  Fly   738 STPSHASSSVH------------PAAAAATPLEPVLLKEGLMTKYPTSR--KRFGRQFKQRHF-R 787
            |.....::|::            ...|....:.|.|.|:.|:...|..|  .......:..|. |
Frog   632 SNLDSLTNSINFEGYIDLGRELSTLHALLWEVIPQLSKDALIKLGPLPRLLNDISLALRNPHIQR 696

  Fly   788 LTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQT-----TNCVE 847
            ..:|.......|   |:.            |:..|.::|:  .:|.:..|.|..|     |....
Frog   697 QPSHQERLPPPK---PVI------------LRGPSAELQS--YLVRDLNSSIDMTRLPSPTKDKP 744

  Fly   848 EREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLV-TAL 911
            .::.|.:..:             |....|..| |...||...|. :|:|........|||. :.:
Frog   745 SKDMFFVSRR-------------PLTRSSPAY-CTSSSDITEPD-QKMLSVNKSVSMMDLQDSRM 794

  Fly   912 DPALDLQRIHTLIMSNMSVLESLLDP-----------LTYHQSLSQ-------TQHQQ------- 951
            :...:||.:..|:.|:.:.:...|.|           :.....|||       ...||
Frog   795 NSVTNLQAVGDLLNSSQASISGGLRPGGRLSQGSGSSIAAGLRLSQMGVTTDGLSAQQLRIPLSF 859

  Fly   952 HNPLVPLATD--------LQKHSP----QAFAEFKRTIEKLREKAYAIDRD---------HRDYK 995
            .|||..:|.|        ...|.|    .|||.|         ..|:...|         ...|.
Frog   860 QNPLFHMAPDGPGGPPSHPAPHRPDPGADAFAPF---------HGYSKSEDLSSGKHMLHSHSYS 915

  Fly   996 QGITRQ-LKYGSRQAPIGDDNYWHM---------------------------------------- 1019
            ...:|| .::..||..: .||..||
Frog   916 DEFSRQGSEFSKRQLSL-QDNLQHMLSPPQITIGPGVPRRQDSQPPPLQRGKSQQLTVQAAHKPR 979

  Fly  1020 ------------MRAAGQLNQQHHQQ----------QQHQQQQQ--------------------- 1041
                        |..|.::.||..::          :||...|.
Frog   980 PSSGNLLQSPEPMYGAARIRQQSVEKDAGGLKPSITKQHSHAQATLNPVTPASERTVAWVSNMPH 1044

  Fly  1042 ----------QQQQQQLQQFQPQPVLPQMQNVRAYPYQPATSNMNAYCLHNMQYQQQRLPFHQQQ 1096
                      ::::.:|:::.......:::.|:.|. :...|......:.|.:.::.......|:
Frog  1045 LSADIESAHIEREEYKLKEYSKSMDESRLERVKEYE-EEIYSLKERLLMSNRKLEEYERRLLTQE 1108

  Fly  1097 QQHHQQLQQQQSQF----QPLRSHQLQRHN------NNLNNNNCGNGSSSSPSSTTSS 1144
            :|.::.:||.||:.    :.||..|:::..      |.|...:.|.|.....|.|.::
Frog  1109 EQTNKMMQQYQSRLDQSEKRLRQQQVEKDTQIKSILNRLEMVDAGGGGDQEGSLTRTN 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	21/116 (18%)
		C2B_RasA3	280..462	CDD:175977	35/205 (17%)
		RasGAP	449..797	CDD:214617	96/364 (26%)
		RasGAP_GAP1_like	473..740	CDD:213330	80/268 (30%)
		PH	761..859	CDD:278594	19/105 (18%)
		PH_GAP1-like	763..867	CDD:269950	18/111 (16%)
		BTK	862..897	CDD:128417	8/34 (24%)
syngap1	XP_031748229.1	PH_SynGAP	108..296	CDD:270178	42/228 (18%)
		C2_SynGAP_like	238..377	CDD:175980	30/177 (17%)
		RasGAP_DAB2IP	368..692	CDD:213338	90/337 (27%)
		DUF3498	682..1191	CDD:403279	86/528 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910